====COG富集====

COG注释参考[[:cog注释|COG注释]]

cog数据库位置：/TJPROJ2/GB/PUBLIC/database/GB_TR/mRNA/noref/cog

使用/TJPROJ7/GB_TR/PUBLIC/source/ncRNA/gb_tr_man_pipline/bin/DisGeNET脚本

使用方法
<code>
/TJPROJ7/GB_TR/PUBLIC/source/ncRNA/gb_tr_man_pipline/bin/DisGeNET --disgenet /TJPROJ13/GB_TR/reference_data/Animal/Homo_sapiens/Homo_sapiens_Ensemble_94/Homo_sapiens_Ensemble_94_disgenet.txt --diffgene /TJPROJ6/NC_BG_SH/shouhou/202302/X101SC22113551-Z01-F001_reanalysis/test/Differential/1.deglist/IFvsMF/IFvsMF_deg_all.xls --diffresult /TJPROJ6/NC_BG_SH/shouhou/202302/X101SC22113551-Z01-F001_reanalysis/test/Differential/1.deglist/IFvsMF/IFvsMF_deg.xls --enrich normal --prefix /TJPROJ6/NC_BG_SH/shouhou/202302/X101SC22113551-Z01-F001_reanalysis/test/Enrichment/5.DisGeNET/IFvsMF/ALL/IFvsMF.all
</code>

需要整理COG的注释文件格式如下

|gene_id|entrez_id|gene_name|disease_id|disease_name|
|ENSG00000121410|1|A1BG|C0001418|Adenocarcinoma|

第一列是gene_id,第二列不用，第三列是COG注释的序列name；第四列是COGid；第5列是COGidterm的description