======简介====== KIR分型,即杀伤细胞免疫球蛋白样受体分型,主要涉及NK细胞及部分T细胞表面的一类受体。杀伤细胞免疫球蛋白样受体(KIRs)在记忆性T细胞和NK细胞上表达,是NK细胞功能的关键调节因子。KIR及其配体MHC-I类(HLA-A、-B、-C)分子具有高度多态性,特殊的相互作用会影响一些疾病的发生率、进展和结果,如妊娠并发症、病毒感染、自身免疫性疾病和血液系统恶性肿瘤。 ======功能====== 利用软件TK1对KIR和HLA同时分型 ======数据准备====== fastq文件,最好是clean ======数据分析====== 1 示例路径====== /TJPROJ6/AFS_RESEQ/Proj/hongxiang/05.AFS/HLA_KIR/KIR ====== 2 分析脚本 /TJPROJ6/AFS_RESEQ/Proj/hongxiang/05.AFS/HLA_KIR/T1K/bin/run-t1k \ -1 FPBSYY_FKDO230630961-1A_H2WH5DSXC_L3_1.fq.gz \ -2 FPBSYY_FKDO230630961-1A_H2WH5DSXC_L3_2.fq.gz \ -f /TJPROJ6/AFS_RESEQ/Proj/hongxiang/05.AFS/HLA_KIR/T1K/T1K-master/kiridx/kiridx_dna_seq.fa \ --preset kir-wgs /TJPROJ6/AFS_RESEQ/Proj/hongxiang/05.AFS/HLA_KIR/T1K/bin/run-t1k \ -1 FPBSYY_FKDO230630961-1A_H2WH5DSXC_L3_1.fq.gz \ -2 FPBSYY_FKDO230630961-1A_H2WH5DSXC_L3_2.fq.gz \ --preset hla \ -f /TJPROJ6/AFS_RESEQ/Proj/hongxiang/05.AFS/HLA_KIR/T1K/T1K-master/hlaidx/hlaidx_dna_seq.fa ======交付结果====== HLA-A 2 HLA-A*02:03:01 152.858684 60 HLA-A*33:03:01 133.517505 60 HLA-B 2 HLA-B*38:02:01 126.169345 60 HLA-B*58:01:01 85.901779 42 HLA-B*35:03:01;25.360357;6 HLA-C 2 HLA-C*03:02:02 103.610108 54 HLA-C*07:02:01 165.047844 60 HLA-E 2 HLA-E*01:03:01 231.036814 60 HLA-E*01:01:01 130.387184 60 HLA-F 2 HLA-F*01:01:01 159.010307 60 HLA-F*01:01:02 131.500342 60 HLA-G 2 HLA-G*01:04:01 223.837985 60 HLA-G*01:01:01 204.208760 60 HLA-H 2 HLA-H*02:08:01 174.114347 60 HLA-H*01:01:01 155.985071 60 HLA-J 1 HLA-J*01:01:01 447.136916 60 . 0 -1 HLA-K 2 HLA-K*01:04 66.880141 35 HLA-K*01:02 54.243614 26 HLA-L 2 HLA-L*01:01:01 116.092688 60 HLA-L*01:03 102.130274 60