id rcd symbol hgncid evidence testin pathway confidence experiments caution uniprotac pmid remark latestupdate datasource 1 Ferroptosis RPL8 HGNC:10368 Required in erastin-induced ferroptosis. Silencing of it conferred against erastin-induced ferroptosis. Human RPL8 :+: Ferroptosis Validated 0 _NA_ P62917 22632970 _NA_ 2020/12/31 FerrDb team 2 Ferroptosis IREB2 HGNC:6115 Required in erastin-induced ferroptosis. Silencing of it conferred against erastin-induced ferroptosis. Human IREB2 :+: Ferroptosis Validated 0 _NA_ P48200 22632970 _NA_ 2020/12/31 FerrDb team 3 Ferroptosis ATP5MC3 HGNC:843 Required in erastin-induced ferroptosis. Silencing of it conferred against erastin-induced ferroptosis. Human ATP5MC3 :+: Ferroptosis Validated 0 _NA_ P48201 22632970 ATP5G3 in article 2020/12/31 FerrDb team 4 Ferroptosis CS HGNC:2422 Required in erastin-induced ferroptosis. Silencing of it conferred against erastin-induced ferroptosis. Human CS :+: Ferroptosis Validated 0 _NA_ O75390 22632970 _NA_ 2020/12/31 FerrDb team 5 Ferroptosis EMC2 HGNC:28963 Required in erastin-induced ferroptosis. Silencing of it conferred against erastin-induced ferroptosis. Human EMC2 :+: Ferroptosis Validated 0 _NA_ Q15006 22632970 TTC35 in article 2020/12/31 FerrDb team 6 Ferroptosis ACSF2 HGNC:26101 Required in erastin-induced ferroptosis. Silencing of it conferred against erastin-induced ferroptosis. Human ACSF2 :+: Ferroptosis Validated 0 _NA_ Q96CM8 22632970 _NA_ 2020/12/31 FerrDb team 7 Ferroptosis NOX1 HGNC:7889 Suppresses erastin-induced ferroptosis when inhibited by inhibitor. Human NOX1 :+: Ferroptosis Deduced 0 The presented inhibition study is not sufficient to confirm its role in ferroptosis. Q9Y5S8 22632970 _NA_ 2020/12/31 FerrDb team 8 Ferroptosis CYBB HGNC:2578 Suppresses erastin-induced ferroptosis when inhibited by inhibitor. Human CYBB :+: Ferroptosis Deduced 0 The presented inhibition study is not sufficient to confirm its role in ferroptosis. P04839 22632970 NOX2 in article 2020/12/31 FerrDb team 9 Ferroptosis NOX3 HGNC:7890 Suppresses erastin-induced ferroptosis when inhibited by inhibitor. Human NOX3 :+: Ferroptosis Deduced 0 The presented inhibition study is not sufficient to confirm its role in ferroptosis. Q9HBY0 22632970 _NA_ 2020/12/31 FerrDb team 10 Ferroptosis NOX4 HGNC:7891 Suppresses erastin-induced ferroptosis when inhibited by inhibitor. Human NOX4 :+: Ferroptosis Deduced 0 The presented inhibition study is not sufficient to confirm its role in ferroptosis. Q9NPH5 22632970 _NA_ 2020/12/31 FerrDb team 11 Ferroptosis NOX5 HGNC:14874 Suppresses erastin-induced ferroptosis when inhibited by inhibitor. Human NOX5 :+: Ferroptosis Deduced 0 The presented inhibition study is not sufficient to confirm its role in ferroptosis. Q96PH1 22632970 _NA_ 2020/12/31 FerrDb team 12 Ferroptosis DUOX1 HGNC:3062 Suppresses erastin-induced ferroptosis when inhibited by inhibitor. Human DUOX1 :+: Ferroptosis Deduced 0 The presented inhibition study is not sufficient to confirm its role in ferroptosis. Q9NRD9 22632970 _NA_ 2020/12/31 FerrDb team 13 Ferroptosis DUOX2 HGNC:13273 Suppresses erastin-induced ferroptosis when inhibited by inhibitor. Human DUOX2 :+: Ferroptosis Deduced 0 The presented inhibition study is not sufficient to confirm its role in ferroptosis. Q9NRD8 22632970 _NA_ 2020/12/31 FerrDb team 14 Ferroptosis G6PD HGNC:4057 Required in erastin-induced ferroptosis. Human G6PD :+: Ferroptosis Validated 0 _NA_ P11413 22632970 _NA_ 2020/12/31 FerrDb team 15 Ferroptosis PGD HGNC:8891 Required in erastin-induced ferroptosis. Human PGD :+: Ferroptosis Validated 0 _NA_ P52209 22632970 _NA_ 2020/12/31 FerrDb team 16 Ferroptosis VDAC2 HGNC:12672 Required in erastin-induced ferroptosis. Human VDAC2 :+: Ferroptosis Validated 0 _NA_ P45880 22632970 _NA_ 2020/12/31 FerrDb team 17 Ferroptosis PIK3CA HGNC:8975 Inhibitor blocked ferroptotic cell death. Mice PIK3CA :-: GSH, GSH :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 Also involved in necrosis and apoptosis. P42336 24739485 PI3Kalpha in article 2020/12/31 FerrDb team 18 Ferroptosis FLT3 HGNC:3765 Inhibitor blocked ferroptotic cell death. Mice FLT3 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 Also involved in necrosis and apoptosis. P36888 24739485 _NA_ 2020/12/31 FerrDb team 19 Ferroptosis SCP2 HGNC:10606 SCP-2 inhibitors showed anti-ferroptotic activity, which was substantiated by knocking down SCP-2 in Gpx4−/− cells. Mice SCP2 :+: Ferroptosis Validated 0 Transient effect. Other translocases may work in parallel. P22307 25402683 _NA_ 2020/12/31 FerrDb team 20 Ferroptosis TP53 HGNC:11998 Inhibits cystine uptake and sensitizes cells to ferroptosis. Erastin induced high levels of cell death in p53+/+ MEFs. Human, mice TP53 :-: SLC7A11, SLC7A11 :+: Cystine, Cystine :-: Ferroptosis Validated 0 The acetylation-defective mutant (p53[3KR]) also retains the ability to induce ferroptosis upon reactive oxygen species (ROS)-induced stress. P04637 25799988 _NA_ 2020/12/31 FerrDb team 21 Ferroptosis ACSL4 HGNC:3571 Deletion of this gene likely suppress ferroptosis by limiting the membrane-resident pool of oxidation-sensitive fatty acids. Human ACSL4 :+: Ferroptosis Predicted 0 Author prediction based on gene function. O60488 25965523 _NA_ 2020/12/31 FerrDb team 22 Ferroptosis LPCAT3 HGNC:30244 Deletion of this gene likely suppress ferroptosis by limiting the membrane-resident pool of oxidation-sensitive fatty acids. Human LPCAT3 :+: Ferroptosis Predicted 0 Author prediction based on gene function. Q6P1A2 25965523 _NA_ 2020/12/31 FerrDb team 23 Ferroptosis NRAS HGNC:7989 NRAS12V mutant protects RMS13 cells from ferroptotic cell death. Human NRAS :+: Ferroptosis Deduced 0 Inferred as a promoter because RAS mutant is resistant to ferroptosis. P01111 26157704 _NA_ 2020/12/31 FerrDb team 24 Ferroptosis KRAS HGNC:6407 KRAS12V mutant protects RMS13 cells from ferroptotic cell death. Human KRAS :+: Ferroptosis Deduced 0 Inferred as a promoter because RAS mutant is resistant to ferroptosis. P01116 26157704 _NA_ 2020/12/31 FerrDb team 25 Ferroptosis HRAS HGNC:5173 HRAS12V mutant protects RMS13 cells from ferroptotic cell death. Human HRAS :+: Ferroptosis Deduced 0 Inferred as a promoter because RAS mutant is resistant to ferroptosis. P01112 26157704 _NA_ 2020/12/31 FerrDb team 26 Ferroptosis TF HGNC:11740 Essential for the induction of ferroptotic cell death. Transferrin can only interact with transferrin receptor and be transported into the cell when it is loaded with iron. Mice TF :+: Ferroptosis Validated 0 Recognized as a suppressor in other studies. P02787 26166707 Transferrin in article 2020/12/31 FerrDb team 27 Ferroptosis TFRC HGNC:11763 RNAi of transferrin receptor (TfR) inhibited ferroptosis. Mice TFRC :+: Ferroptosis Validated 0 _NA_ P02786 26166707 Tfr in article 2020/12/31 FerrDb team 28 Ferroptosis TFR2 HGNC:11762 RNAi of transferrin receptor (TfR) inhibited ferroptosis. Mice TFR2 :+: Ferroptosis Validated 0 _NA_ Q9UP52 26166707 Tfr in article 2020/12/31 FerrDb team 29 Ferroptosis SLC38A1 HGNC:13447 RNAi knockdown markedly blocked ferroptosis. Mice SLC38A1 :+: Glutamine, Glutamine :+: Glutamate, Glutamate :+: alpha-Ketoglutarate, alpha-Ketoglutarate :+: Ferroptosis Validated 0 _NA_ Q9H2H9 26166707 _NA_ 2020/12/31 FerrDb team 30 Ferroptosis SLC1A5 HGNC:10943 Pharmacological inhibition by L-g-glutamyl-p-nitroanilide or RNAi knockdown markedly blocked ferroptosis. Mice SLC1A5 :+: Glutamine, Glutamine :+: Glutamate, Glutamate :+: alpha-Ketoglutarate, alpha-Ketoglutarate :+: Ferroptosis Validated 0 _NA_ Q15758 26166707 _NA_ 2020/12/31 FerrDb team 31 Ferroptosis GLS2 HGNC:29570 Both inhibitor inhibition and gene knockdown inhibit ferroptotic cell death. Mice GSL2 :+: Glutamate, Glutamate :+: Ferroptosis Validated 0 _NA_ Q9UI32 26166707 _NA_ 2020/12/31 FerrDb team 32 Ferroptosis GOT1 HGNC:4432 RNAi reduced ferroptosis. Mice GOT1 :+: alpha-Ketoglutarate, alpha-Ketoglutarate :+: Ferroptosis Validated 0 _NA_ P17174 26166707 _NA_ 2020/12/31 FerrDb team 33 Ferroptosis CARS1 HGNC:1493 Required for ferroptosis in diverse cell contexts. Knockdown of CARS inhibited erastin-induced death by preventing the induction of lipid reactive oxygen species, without altering iron homeostasis. Human, rat CARS1 :-: Transsulfuration pathway, Transsulfuration pathway :-: Ferroptosis Validated 0 _NA_ P49589 26184909 CARS in article 2020/12/31 FerrDb team 34 Ferroptosis TP53 HGNC:11998 Wild type p53 can induce ferroptosis upon reactive oxygen species (ROS)-induced stress. Human TP53 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P04637 26218928 p53 in article 2020/12/31 FerrDb team 35 Ferroptosis ALOX5 HGNC:435 The 5-Lipoxygenase inhibitor zileuton protected HT22 neuronal cells from erastin-induced ferroptosis. Mice ALOX5 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P09917 26235588 5-LOX in article 2020/12/31 FerrDb team 36 Ferroptosis KEAP1 HGNC:23177 Knockdown of Keap1 reversed loss of p62-increased degradation of NRF2 in ferroptosis. Keap1 knockdown led to resistance to erastin-induced and sorafenib-induced growth inhibition with decreased ferroptotic events in the absence or presence of p62 knockdown. Human, mice KEAP1 :-: NFE2L2, NFE2L2 :-: Ferroptosis Validated 0 _NA_ Q14145 26403645 _NA_ 2020/12/31 FerrDb team 37 Ferroptosis HMOX1 HGNC:5013 Zinc protoporphyrin IX, a HO-1 inhibitor, prevented Erastin-triggered ferroptotic cancer cell death. Overexpression accelerates erastin-induced cell death. Human, mice HMOX1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 Other articles (PMID 26403645, 28515173) suggest it a suppressor. P09601 26405158 HO-1 in article 2020/12/31 FerrDb team 38 Ferroptosis TP53 HGNC:11998 p53^3KR/3KR Xrcc4^-/- MEF cells are very sensitive to ferroptosis. Stabilized in the spleens of p53^3KR/3KR Xrcc4^-/- mice which enables to prevent the development of pro-B-cell lymphomas. Mice TP53 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P04637 26943586 p53 in article 2020/12/31 FerrDb team 39 Ferroptosis TP53 HGNC:11998 Incubation with erastin led to profound cell death in wild-type MEFs. Human, mice TP53 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P04637 27034505 p53 in article 2020/12/31 FerrDb team 40 Ferroptosis GLS2 HGNC:29570 Upregulated in erastin-treated wild-type MEFs, and silencing Gls2 exihibits cell death defect in wild-type MEFs treated with erastin. Mice GLS2 :+: Ferroptosis Validated 0 _NA_ Q9UI32 27034505 _NA_ 2020/12/31 FerrDb team 41 Ferroptosis ATG5 HGNC:589 Knockout or knockdown limited erastin-induced ferroptosis. Human, mice ATG5 :+: Ferroptosis Validated 0 _NA_ Q9H1Y0 27245739 _NA_ 2020/12/31 FerrDb team 42 Ferroptosis ATG7 HGNC:16935 Knockout or knockdown limited erastin-induced ferroptosis. Human, mice ATG7 :+: Ferroptosis Validated 0 _NA_ O95352 27245739 _NA_ 2020/12/31 FerrDb team 43 Ferroptosis NCOA4 HGNC:7671 Inhibition suppressed ferroptosis, and overexpression promoted ferroptosis. Human NCOA4 :-: FTH1, FTH1 :-: Ferroptosis Validated 0 _NA_ Q13772 27245739 _NA_ 2020/12/31 FerrDb team 44 Ferroptosis TF HGNC:11740 Involved in siramesine and lapatinib-induced ferroptotic cell death. Increased following treatment with lapatinib alone or in combination with siramesine. Knocking down of transferrin resulted in decreased cell death and ROS after treatment. Human TF :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 Recognized as a suppressor in other studies. P02787 27441659 Transferrin in article 2020/12/31 FerrDb team 45 Ferroptosis ALOX5 HGNC:435 Silencing ALOX genes made cells resistant to ferroptosis. Human ALOX5 :+: PUFAs peroxidation, PUFAs peroxidation :+: Ferroptosis Validated 0 _NA_ P09917 27506793 _NA_ 2020/12/31 FerrDb team 46 Ferroptosis ALOX12 HGNC:429 Silencing ALOX genes made cells resistant to ferroptosis. Human ALOX12 :+: PUFAs peroxidation, PUFAs peroxidation :+: Ferroptosis Validated 0 _NA_ P18054 27506793 _NA_ 2020/12/31 FerrDb team 47 Ferroptosis ALOX12B HGNC:430 Silencing ALOX genes made cells resistant to ferroptosis. Human ALOX12B :+: PUFAs peroxidation, PUFAs peroxidation :+: Ferroptosis Validated 0 _NA_ O75342 27506793 _NA_ 2020/12/31 FerrDb team 48 Ferroptosis ALOX15 HGNC:433 Silencing ALOX genes made cells resistant to ferroptosis. Human ALOX15 :+: PUFAs peroxidation, PUFAs peroxidation :+: Ferroptosis Validated 0 _NA_ P16050 27506793 _NA_ 2020/12/31 FerrDb team 49 Ferroptosis ALOX15B HGNC:434 Silencing ALOX genes made cells resistant to ferroptosis. Erastin-induced cell death was rescued by silencing either ALOX15B or ALOXE3, which supported the hypothesis that lipoxygenases are required for ferroptosis. Human ALOX15B :+: PUFAs peroxidation, PUFAs peroxidation :+: Ferroptosis Validated 0 _NA_ O15296 27506793 _NA_ 2020/12/31 FerrDb team 50 Ferroptosis ALOXE3 HGNC:13743 Silencing ALOX genes made cells resistant to ferroptosis. Erastin-induced cell death was rescued by silencing either ALOX15B or ALOXE3, which supported the hypothesis that lipoxygenases are required for ferroptosis. Human ALOXE3 :+: PUFAs peroxidation, PUFAs peroxidation :+: Ferroptosis Validated 0 _NA_ Q9BYJ1 27506793 _NA_ 2020/12/31 FerrDb team 51 Ferroptosis PHKG2 HGNC:8931 U-2-OS cells became resistant to erastin upon PHKG2 silencing. Erastin-treated HT-1080 cells were rescued by shPHKG2. Human PHKG2 :+: PUFAs peroxidation, PUFAs peroxidation :+: Ferroptosis Validated 0 _NA_ P15735 27506793 _NA_ 2020/12/31 FerrDb team 52 Ferroptosis TFRC HGNC:11763 The gene targets of the enriched shRNAs are potential genes that positively regulate ferroptosis. Mice TFRC :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ P02786 27514700 _NA_ 2020/12/31 FerrDb team 53 Ferroptosis ACO1 HGNC:117 The gene targets of the enriched shRNAs are potential genes that positively regulate ferroptosis. Mice ACO1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ P21399 27514700 _NA_ 2020/12/31 FerrDb team 54 Ferroptosis IREB2 HGNC:6115 The gene targets of the enriched shRNAs are potential genes that positively regulate ferroptosis. Mice IREB2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ P48200 27514700 _NA_ 2020/12/31 FerrDb team 55 Ferroptosis SLC38A1 HGNC:13447 The gene targets of the enriched shRNAs are potential genes that positively regulate ferroptosis. Mice SLC38A1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q9H2H9 27514700 _NA_ 2020/12/31 FerrDb team 56 Ferroptosis GLS2 HGNC:29570 The gene targets of the enriched shRNAs are potential genes that positively regulate ferroptosis. Mice GLS2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q9UI32 27514700 _NA_ 2020/12/31 FerrDb team 57 Ferroptosis G6PDX _NA_ The gene targets of the enriched shRNAs are potential genes that positively regulate ferroptosis. Mice G6PDX :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ _NA_ 27514700 Not found in HGNC 2020/12/31 FerrDb team 58 Ferroptosis ULK1 HGNC:12558 Potential positive regulators of ferroptosis. Knockout of ULK1 led to significantly lower levels of erastin-induced ferroptosis in a dose- and time-dependent manner. Mice ULK1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O75385 27514700 _NA_ 2020/12/31 FerrDb team 59 Ferroptosis ATG3 HGNC:20962 Potential positive regulators of ferroptosis. Knockout of ATG3 greatly reduced the sensitivity of MEFs to ferropotosis, and reconstituting ATG3 back to these cells restored the ferroptosis sensitivity. Mice ATG3 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9NT62 27514700 _NA_ 2020/12/31 FerrDb team 60 Ferroptosis ATG4D HGNC:20789 Potential positive regulators of ferroptosis. Mice ATG4D :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q86TL0 27514700 _NA_ 2020/12/31 FerrDb team 61 Ferroptosis ATG5 HGNC:589 Potential positive regulators of ferroptosis. Knockout of ATG5 led to significantly lower levels of erastin-induced ferroptosis in a dose- and time-dependent manner. Mice ATG5 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9H1Y0 27514700 _NA_ 2020/12/31 FerrDb team 62 Ferroptosis BECN1 HGNC:1034 Potential positive regulators of ferroptosis. Mice BECN1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q14457 27514700 _NA_ 2020/12/31 FerrDb team 63 Ferroptosis MAP1LC3A HGNC:6838 Potential positive regulators of ferroptosis. Mice MAP1LC3A :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q9H492 27514700 _NA_ 2020/12/31 FerrDb team 64 Ferroptosis GABARAPL2 HGNC:13291 Potential positive regulators of ferroptosis. Mice GABARAPL2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ P60520 27514700 _NA_ 2020/12/31 FerrDb team 65 Ferroptosis GABARAPL1 HGNC:4068 Potential positive regulators of ferroptosis. Mice GABARAPL1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q9H0R8 27514700 _NA_ 2020/12/31 FerrDb team 66 Ferroptosis ATG16L1 HGNC:21498 Potential positive regulators of ferroptosis. Mice ATG16L1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q676U5 27514700 _NA_ 2020/12/31 FerrDb team 67 Ferroptosis WIPI1 HGNC:25471 Potential positive regulators of ferroptosis. Mice WIPI1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q5MNZ9 27514700 _NA_ 2020/12/31 FerrDb team 68 Ferroptosis WIPI2 HGNC:32225 Potential positive regulators of ferroptosis. Mice WIPI2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ Q9Y4P8 27514700 _NA_ 2020/12/31 FerrDb team 69 Ferroptosis SNX4 HGNC:11175 Potential positive regulators of ferroptosis. Mice SNX4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Screened 0 _NA_ O95219 27514700 _NA_ 2020/12/31 FerrDb team 70 Ferroptosis ATG13 HGNC:29091 Knockout of ATG13 greatly reduced the sensitivity of MEFs to ferropotosis, and reconstituting ATG13 back to these cells restored the ferroptosis sensitivity. Mice ATG13 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O75143 27514700 _NA_ 2020/12/31 FerrDb team 71 Ferroptosis ULK2 HGNC:13480 Knockout of ULK2 led to significantly lower levels of erastin-induced ferroptosis in a dose- and time-dependent manner. Mice ULK2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q8IYT8 27514700 _NA_ 2020/12/31 FerrDb team 72 Ferroptosis NCOA4 HGNC:7671 Elimination of NCOA4 expression by RNAi knockdown significantly block ferroptosis Human, mice NCOA4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q13772 27514700 _NA_ 2020/12/31 FerrDb team 73 Ferroptosis ACSL4 HGNC:3571 Knockdown inhibited erastin-induced ferroptosis, whereas overexpression restored ferroptosis sensitization. Human ACSL4 :+: 5-HETE, 5-HETE :+: Ferroptosis Validated 0 _NA_ O60488 27565726 _NA_ 2020/12/31 FerrDb team 74 Ferroptosis TP53 HGNC:11998 p53 acetylation has a critical role in ferroptotic responses. Simultaneous loss of K98/117/161/162 acetylations is unable to induce ferroptosis, and its ability to thwart cancer growth is also abrogated. Human, mice TP53 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P04637 27705786 _NA_ 2020/12/31 FerrDb team 75 Ferroptosis SAT1 HGNC:10540 p53-mediated activation of SAT1 contributes to ferroptotic cell death in the presence of ROS stress. Knockdown of Sat1 partially rescued ROS-induced ferroptosis. Human, mice SAT1 :+: ALOX15, ALOX15 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 Activated by p53. P21673 27698118 _NA_ 2020/12/31 FerrDb team 76 Ferroptosis ALOX15 HGNC:433 SAT1- and ROS-induced ferroptosis was completely abrogated by PD146176, an ALOX15-specific inhibitor. Human ALOX15 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P16050 27698118 _NA_ 2020/12/31 FerrDb team 77 Ferroptosis ACSL4 HGNC:3571 Inhibition of ACSL4 was effective in protecting against RSL3-induced cell death. Acsl4 KO cells are resistant to ferroptosis. Mice ACSL4 :+: PE, PE :+: Ferroptosis Validated 0 _NA_ O60488 27842066 _NA_ 2020/12/31 FerrDb team 78 Ferroptosis LPCAT3 HGNC:30244 Knockdown of Lpcat3 increased resistance to ferroptosis triggered by RSL3. Mice LPCAT3 :+: Ferroptosis Validated 0 _NA_ Q6P1A2 27842066 _NA_ 2020/12/31 FerrDb team 79 Ferroptosis ALOX15 HGNC:433 Liproxstatin-1 inhibited the 15-LOX enzymatic activity and suppressed ferroptosis. Mice ALOX15 :+: PE, PE :+: Ferroptosis Validated 0 _NA_ P16050 27842066 15-LOX in article 2020/12/31 FerrDb team 80 Ferroptosis ACSL4 HGNC:3571 An essential proferroptotic gene. Re-expression of Flag-tagged human wild-type (WT) ACSL4 (ACSL4-Flag) in Acsl4 KO Pfa1 cells restored full sensitivity to ferroptosis induction. Inhibition showed significantly prolonged survival compared to vehicle-treated mice. Human, mice ACSL4 :+: Ferroptosis Validated 0 _NA_ O60488 27842070 _NA_ 2020/12/31 FerrDb team 81 Ferroptosis KEAP1 HGNC:23177 Keap 1 silencing decreased ferroptosis. Mice KEAP1 :-: NFE2L2, NFE2L2 :-: Ferroptosis Validated 0 _NA_ Q14145 28012440 _NA_ 2020/12/31 FerrDb team 82 Ferroptosis EGFR HGNC:3236 Cell death in activated EGFR mutant cells occurs by ferroptosis. Inhibiting EGFR and MAPK signaling rescued cell viability following cystine withdrawal. Human EGFR :+: MAPK, MAPK :+: Ferroptosis Validated 0 _NA_ P00533 28297659 _NA_ 2020/12/31 FerrDb team 83 Ferroptosis NOX4 HGNC:7891 Inhibition of NADPH oxidase 4 (NOX4) blocked ferroptosis. Human NOX4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9NPH5 28297659 _NA_ 2020/12/31 FerrDb team 84 Ferroptosis MAPK3 HGNC:6877 Inhibiting EGFR and MAPK signaling rescued cell viability following cystine withdrawal. Human MAPK :-: GPX4, GPX4 :-: Lipid ROS, MAPK :+: NOX4, NOX4 :+: H2O2, H2O2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P27361 28297659 ERK1 in article 2020/12/31 FerrDb team 85 Ferroptosis MAPK1 HGNC:6871 Inhibiting EGFR and MAPK signaling rescued cell viability following cystine withdrawal. Human MAPK :-: GPX4, GPX4 :-: Lipid ROS, MAPK :+: NOX4, NOX4 :+: H2O2, H2O2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P28482 28297659 ERK2 in article 2020/12/31 FerrDb team 86 Ferroptosis BID HGNC:1050 BID deletion prevents erastin- and glutamate-induced cell death. BID inhibition inhibited erastin-induced ferroptosis. Mice BID :+: Ferroptosis Validated 0 _NA_ P55957 28384611 _NA_ 2020/12/31 FerrDb team 87 Ferroptosis ACSL4 HGNC:3571 Knockout of Acsl4 in ferroptosis-sensitive cells conferred protection from erastin- and RSL3-induced cell death. Human, mice ACSL4 :+: Ferroptosis Validated 0 _NA_ O60488 28551825 _NA_ 2020/12/31 FerrDb team 88 Ferroptosis ZEB1 HGNC:11642 Knockout of ZEB1 prevents cell death induced by GPX4 inhibition. Human ZEB1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P37275 28678785 _NA_ 2020/12/31 FerrDb team 89 Ferroptosis KEAP1 HGNC:23177 Keap1 inhibition promotes resistance to ferroptosis. Human, rat KEAP1 :+: Ferroptosis Validated 0 _NA_ Q14145 28805788 _NA_ 2020/12/31 FerrDb team 90 Ferroptosis DPP4 HGNC:3009 Required for ferroptosis in TP53-deficient CRC cells. Human, mice DPP4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P27487 28813679 _NA_ 2020/12/31 FerrDb team 91 Ferroptosis ALOX15 HGNC:433 Suppression of ferroptosis following ALOX15 silencing was detected in cancer cells. Cells with exogenous expression of ALOX15 had an increased cell death rate following RSL3 treatment. Human ALOX15 :+: Ferroptosis Validated 0 _NA_ P16050 28837253 _NA_ 2020/12/31 FerrDb team 92 Ferroptosis ALOX12 HGNC:429 12‐LOX inhibitors prevented cell death, whereas ALOX12 overexpression significantly enhanced cell death. ALOX12 expression was gradually elevated during the erastin or RSL3 treatments, and was stable in the late stage of ferroptosis. Human ALOX12 :+: Ferroptosis Validated 0 _NA_ P18054 28837253 _NA_ 2020/12/31 FerrDb team 93 Ferroptosis CDKN2A HGNC:1787 Combination of ARF induction and ROS treatment induced ferroptotic cell death. Knockdown of endogenous ARF protected cells from ROS-induced cell death. Human, mice CDKN2A :-: NFE2L2, NFE2L2 :+: SLC7A11, SLC7A11 :-: Ferroptosis, CDKN2A :+: p53, p53 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P42771 28985506 ARF in article 2020/12/31 FerrDb team 94 Ferroptosis PEBP1 HGNC:8630 Elevated levels of PEBP1 resulted in increased sensitivity of HK2 cells to RSL3 whereas lowered contents of PEBP1 in HAEC and HT22 cells were associated with decreased sensitivity to ferroptosis. Human, mice (PEBP1/15LO) :+: Ferroptosis Validated 0 _NA_ P30086 29053969 _NA_ 2020/12/31 FerrDb team 95 Ferroptosis SOCS1 HGNC:19383 Expression of SOCS1 sensitized cells to ferroptosis inducer. This effect of SOCS1 was efficiently blocked by ferroptosis inhibitor. Expression of SOCS1 reduced the levels of GSH, explaining in part its ability to sensitize cells to ferroptosis. Human SOCS1 :+: p53, p53 :-: SLC7A11, SLC7A11 :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ O15524 29081404 _NA_ 2020/12/31 FerrDb team 96 Ferroptosis CDO1 HGNC:1795 CDO1 suppression contributes to ferroptosis resistance. Human CDO1 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q16878 29144989 _NA_ 2020/12/31 FerrDb team 97 Ferroptosis MYB HGNC:7545 Erastin-induced ferroptosis was restrained when c-Myb was suppressed. Human MYB :+: CDO1, CDO1 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P10242 29144989 C-Myb in article 2020/12/31 FerrDb team 98 Ferroptosis HMOX1 HGNC:5013 Inhibiting HO-1 effectively attenuated BAY-induced ferroptotic cell death. Defective HO-1 expression significantly rescued cell survival suppressed by BAY. Human HMOX1 :+: Ferroptosis Validated 0 _NA_ P09601 29274359 HO-1 in article 2020/12/31 FerrDb team 99 Ferroptosis MAPK8 HGNC:6881 JNK1/2 inhibitors inhibited t-BHP-induced ferroptosis. t-BHP treatment significantly increased the protein expression of p-JNK. Rat MAPK8 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P45983 29330409 JNK1 in article 2020/12/31 FerrDb team 100 Ferroptosis MAPK9 HGNC:6886 JNK1/2 inhibitors inhibited t-BHP-induced ferroptosis. t-BHP treatment significantly increased the protein expression of p-JNK. Rat MAPK9 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P45984 29330409 JNK2 in article 2020/12/31 FerrDb team 101 Ferroptosis MAPK1 HGNC:6871 ERK1/2 inhibitors inhibited t-BHP-induced ferroptosis. t-BHP treatment significantly increased the protein expression of p-ERK. Rat MAPK1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P28482 29330409 ERK2 in article 2020/12/31 FerrDb team 102 Ferroptosis MAPK3 HGNC:6877 ERK1/2 inhibitors inhibited t-BHP-induced ferroptosis. t-BHP treatment significantly increased the protein expression of p-ERK. Rat MAPK3 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P27361 29330409 ERK1 in article 2020/12/31 FerrDb team 103 Ferroptosis SLC1A5 HGNC:10943 Overexpression of SLC1A5 restored miR-137-mediated ferroptosis suppression. Human SLC1A5 :+: Glutaminolysis, Glutaminolysis :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q15758 29348676 _NA_ 2020/12/31 FerrDb team 104 Ferroptosis CHAC1 HGNC:28680 CHAC1 degradation of GSH might enhance cystine-starvation-induced cell death. Human CHAC1 :-: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q9BUX1 29383104 _NA_ 2020/12/31 FerrDb team 105 Ferroptosis MAPK14 HGNC:6876 Ferroptosis was blocked by inhibiting p38 MAPK activation. Mice MAPK14 :+: Ferroptosis Validated 0 _NA_ Q16539 29436589 p38 MAPK in article 2020/12/31 FerrDb team 106 Ferroptosis LINC00472 HGNC:21380 Increases erastin-induced growth inhibition, whereas depletion of P53RRA decreased erastin-induced growth inhibition. Human LINC00472 :+: p53, p53 :+: Ferroptosis Validated 0 Also triggers apoptosis. Q9H8W2 29588351 P53RRA in article 2020/12/31 FerrDb team 107 Ferroptosis NOX4 HGNC:7891 Activated Nox4 contributes to PAB-induced ferroptotic cell death. knockdown made cells resistant to PAB-induced death. Human, rat NOX4 :+: H2O2, H2O2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9NPH5 29702192 _NA_ 2020/12/31 FerrDb team 108 Ferroptosis GOT1 HGNC:4432 Overexpression of miR‐9 suppressed GOT1, which subsequently reduced ferroptosis. Overexpression of GOT1 restored miR‐9 mediated ferroptosis suppression. Human GOT1 :+: alpha KG, alpha KG :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P17174 30035324 _NA_ 2020/12/31 FerrDb team 109 Ferroptosis BECN1 HGNC:1034 Knockdown inhibits ferroptosis. Overexpression increases ferroptotic cancer cell death. Human, mice BECN1 :-: System Xc-, System Xc- :+: GSH, GSH :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q14457 30057310 _NA_ 2020/12/31 FerrDb team 110 Ferroptosis PRKAA2 HGNC:9377 Inhibition of PRKAA/AMPKalpha diminishes ferroptosis. Human PRKAA2 :+: (BECN1/SLC7A11), (BECN1/SLC7A11) :+: Ferroptosis Validated 0 _NA_ P54646 30057310 PRKAA in article 2020/12/31 FerrDb team 111 Ferroptosis PRKAA1 HGNC:9376 Inhibition of PRKAA/AMPKalpha diminishes ferroptosis. Human PRKAA1 :+: (BECN1/SLC7A11), (BECN1/SLC7A11) :+: Ferroptosis Validated 0 _NA_ Q13131 30057310 AMPK alpha in article 2020/12/31 FerrDb team 112 Ferroptosis ELAVL1 HGNC:3312 ELAVL1 siRNA led to ferroptosis resistance, whereas ELAVL1 plasmid contributed to classical ferroptotic events. Human, mice ELAVL1 :+: Ferroptosis Validated 0 _NA_ Q15717 30081711 _NA_ 2020/12/31 FerrDb team 113 Ferroptosis BAP1 HGNC:950 Suppresses SLC7A11-mediated cystine uptake and promotes ferroptosis. BAP1 mutants lose their abilities to repress SLC7A11 and to promote ferroptosis. Human BAP1 :-: SLC7A11, SLC7A11 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q92560 30202049 _NA_ 2020/12/31 FerrDb team 114 Ferroptosis TP53 HGNC:11998 Facilitates ART-induced ferroptosis. Conversely, knockdown of P53 blocked ART-induced ferroptosis. Rat TP53 :+: Ferroptosis Validated 0 _NA_ P04637 30321484 P53 in article 2020/12/31 FerrDb team 115 Ferroptosis ABCC1 HGNC:51 Accelerates ferroptosis. Disruption of MRP1 inhibited ferroptosis potently. Human ABCC1 :-: GSH, GSH :-: Ferroptosis Validated 0 _NA_ P33527 30726737 MRP1 in article 2020/12/31 FerrDb team 116 Ferroptosis ACSL4 HGNC:3571 Inhibition suppresses ferroptosis. Human, mice ACSL4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O60488 30737476 _NA_ 2020/12/31 FerrDb team 117 Ferroptosis MIR6852 HGNC:49993 Promotes ferroptosis. Binds to LINC0033 and serves as a negative upstream regulator of CBS-mediated ferroptosis inhibition. Human MIR6852 :-: CBS, CBS :-: Ferroptosis Validated 0 _NA_ _NA_ 30787392 _NA_ 2020/12/31 FerrDb team 118 Ferroptosis ACVR1B HGNC:172 Inhibition attenuated erastin-induced ferroptosis. Human ACVR1B :-: NFE2L2, NFE2L2 :-: Ferroptosis Validated 0 _NA_ P36896 30804470 ALK4 in article 2020/12/31 FerrDb team 119 Ferroptosis TGFBR1 HGNC:11772 Inhibition attenuated erastin-induced ferroptosis. Human TGFBR1 :-: NFE2L2, NFE2L2 :-: Ferroptosis Validated 0 _NA_ P36897 30804470 ALK5 in article 2020/12/31 FerrDb team 120 Ferroptosis BAP1 HGNC:950 Promotes ferroptosis induced by class I ferroptosis inducer. Human BAP1 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q92560 30907299 _NA_ 2020/12/31 FerrDb team 121 Ferroptosis EPAS1 HGNC:3374 A driver of ferroptosis susceptibility. Ablation reduced susceptibility to ferroptosis. Mice EPAS1 :+: HILPDA, EPAS1 :+: PLIN2, HILPDA :+: PUFA, PLIN2 :+: PUFA, PUFA :+: PUFA-phospholipid hydroperoxides, PUFA-phospholipid hydroperoxides :+: Ferroptosis Validated 0 _NA_ Q99814 30962421 HIF-2alpha in article 2020/12/31 FerrDb team 122 Ferroptosis HILPDA HGNC:28859 Promotes ferroptosis sensitivity downstream of HIF-2alpha. Mice HILPDA :+: PUFA, PUFA :+: PUFA-phospholipid hydroperoxides, PUFA-phospholipid hydroperoxides :+: Ferroptosis Validated 0 _NA_ Q9Y5L2 30962421 _NA_ 2020/12/31 FerrDb team 123 Ferroptosis HIF1A HGNC:4910 Re-sensitized HIF-2alpha-null cells to ferroptosis. Induce ferroptosis sensitivity in cancer cells. Mice HIF1A :+: HILPDA, HIF1A :+: PLIN2, HILPDA :+: PUFA, PLIN2 :+: PUFA, PUFA :+: PUFA-phospholipid hydroperoxides, PUFA-phospholipid hydroperoxides :+: Ferroptosis Validated 0 _NA_ Q16665 30962421 HIF-1alpha in article 2020/12/31 FerrDb team 124 Ferroptosis ALOX12 HGNC:429 An essential factor of p53-dependent ferroptosis. Loss of one Alox12 allele is sufficient to abrogate p53-mediated ferroptosis. Human, mice ALOX12 :+: PUFAs-OOH, PUFAs-OOH :+: Ferroptosis Validated 0 _NA_ P18054 30962574 _NA_ 2020/12/31 FerrDb team 125 Ferroptosis ACSL4 HGNC:3571 Required for ferroptosis induced by erastin. ACSL4-null cells are resistant to ferroptosis induced by either erastin. Human ACSL4 :+: Ferroptosis Validated 0 _NA_ O60488 30962574 _NA_ 2020/12/31 FerrDb team 126 Ferroptosis HMOX1 HGNC:5013 Enhances the ferroptotic process in PRDX6-silenced cells by promoting cellular accumulation of ferrous ions. Overexpression increases both erastin and RSL-3-induced lipid ROS. Human HMOX1 :+: Ferroptosis Validated 0 _NA_ P09601 31036877 _NA_ 2020/12/31 FerrDb team 127 Ferroptosis IFNG HGNC:5438 Interferon gamma released from CD8+ T cells downregulates the expression of SLC3A2 and SLC7A11, and as a consequence, promotes tumour cell lipid peroxidation and ferroptosis. Human, mice IFNG :-: SLC3A2, IFNG :-: SLC7A11, SLC3A2 :+: System Xc-, SLC7A11 :+: System Xc-, System Xc- :+: Cystine, Cystine :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P01579 31043744 IFNgamma in article 2020/12/31 FerrDb team 128 Ferroptosis ANO6 HGNC:25240 Essential for ferroptosis. Inhibition blocked ferroptotic cell death induced by RSL3/erastin. Human, mice ANO6 :+: Ferroptosis Validated 0 _NA_ Q4KMQ2 31060306 _NA_ 2020/12/31 FerrDb team 129 Ferroptosis LPIN1 HGNC:13345 Overexpression of adipose lipin‐1 in mice facilitated the onset of hepatic ferroptosis. Mice LPIN1 :+: Ferroptosis Validated 0 _NA_ Q14693 31061954 _NA_ 2020/12/31 FerrDb team 130 Ferroptosis HMGB1 HGNC:4983 Required for erastin-induced ferroptosis. Knockdown of HMGB1 decreased erastin-induced cell death. Human, mice HMGB1 :+: Ferroptosis Validated 0 _NA_ P09429 31105999 _NA_ 2020/12/31 FerrDb team 131 Ferroptosis TNFAIP3 HGNC:11896 Overexpression increased ROS generation and enhanced erastin-induced ferroptosis, whereas knockdown inhibited erastin-induced ferroptosis. Human TNFAIP3 :+: ACSL4, ACSL4 :+: Lipid ROS, TNFAIP3 :-: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P21580 31160087 Zinc lipoprotein A20 in article 2020/12/31 FerrDb team 132 Ferroptosis TLR4 HGNC:11850 Knockdown inhibited ferroptosis. Rat TLR4 :+: Ferroptosis Validated 0 _NA_ O00206 31196626 _NA_ 2020/12/31 FerrDb team 133 Ferroptosis NOX4 HGNC:7891 Knockdown inhibited ferroptosis. Rat NOX4 :+: Ferroptosis Validated 0 _NA_ Q9NPH5 31196626 _NA_ 2020/12/31 FerrDb team 134 Ferroptosis ATF3 HGNC:785 Promotes ferroptosis induced by erastin. Human ATF3 :-: SLC7A11, SLC7A11 :+: System Xc-, System Xc- :+: GSH, GSH :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P18847 31273299 _NA_ 2020/12/31 FerrDb team 135 Ferroptosis ATM HGNC:795 Essential for ferroptosis. Genetic knockdown and chemical inhibition of ATM both suppress ferroptotic cell death. Human ATM :-: MTF1, MTF1 :+: FTL, MTF1 :+: FTH1, FTL :-: Ferroptosis, FTH1 :-: Ferroptosis Validated 0 _NA_ Q13315 31320750 _NA_ 2020/12/31 FerrDb team 136 Ferroptosis YY1AP1 HGNC:30935 Makes cells more sensitive to ferroptosis. Cells lacking YAP were no longer sensitised to ferroptosis. Human, mice YAP :+: ACSL4, ACSL4 :+: Ferroptosis, YAP :+: TFRC, TFRC :+: Ferroptosis Validated 0 _NA_ Q9H869 31341276 YAP in article 2020/12/31 FerrDb team 137 Ferroptosis EGLN2 HGNC:14660 Inhibiting EGLN2 activation diminished ferroptotic tumor cell death. Human, mice EGLN2 :-: HIF1A, HIF1A :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q96KS0 31355331 _NA_ 2020/12/31 FerrDb team 138 Ferroptosis MIOX HGNC:14522 Overexpression exacerbates cell death, knockdown inhibits ferroptosis. Human, mice MIOX :-: GPX4, GPX4 :-: Ferroptosis, MIOX :-: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q9UGB7 31437128 _NA_ 2020/12/31 FerrDb team 139 Ferroptosis TAZ HGNC:11577 TAZ removal confers ferroptosis resistance, whereas overexpression of TAZS89A sensitizes cells to ferroptosis. Human, mice TAZ :+: EMP1, EMP1 :+: NOX4, NOX4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q16635 31484063 _NA_ 2020/12/31 FerrDb team 140 Ferroptosis MTDH HGNC:29608 Can enhance sensitivity to inducers of ferroptosis. Enhances the vulnerability of cancer cells to ferroptosis. Human, mice MTDH :-: Cysteine, Cystein :-: Ferroptosis, MTDH :-: SLC3A2, SLC3A2 :-: Ferroptosis, MTDH :-: GPX4, GPX4 :-: Ferroptosis, MTDH :-: GSH, GSH :-: Ferroptosis, MTDH :+: Glutamate, Glutamate :+: Ferroptosis Validated 0 _NA_ Q86UE4 31527591 _NA_ 2020/12/31 FerrDb team 141 Ferroptosis IDH1 HGNC:5382 Deletion of the mutant IDH1 allele or pharmacological inhibition of mutant IDH1 confers resistance to erastin-induced ferroptosis. Ectopic expression of mutant IDH1 promotes ferroptosis. Human IDH1 :-: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, IDH1 :-: GSH, GSH :-: Ferroptosis Validated 0 _NA_ O75874 31591388 _NA_ 2020/12/31 FerrDb team 142 Ferroptosis SIRT1 HGNC:14929 Knockout partially mitigates ferroptosis. Mice SIRT1 :+: Ferroptosis Predicted 0 _NA_ Q96EB6 31610175 _NA_ 2020/12/31 FerrDb team 143 Ferroptosis TAZ HGNC:11577 TAZ removal confers ferroptosis resistance, while TAZS89A overexpression sensitizes cells to ferroptosis. Human TAZ :+: ANGPTL4, ANGPTL4 :+: NOX2, NOX2 :+: Ferroptosis Validated 0 _NA_ Q16635 31641008 _NA_ 2020/12/31 FerrDb team 144 Ferroptosis BECN1 HGNC:1034 Overexpression aggravated isoflurane-induced cell damage by upregulating ferroptosis. This phenomenon was significantly attenuated by silencing of Beclin1. Human (Beclin1/SLC7A11) :-: System Xc-, System Xc- :-: Ferroptosis Validated 0 _NA_ Q14457 31650158 Beclin1 in article 2020/12/31 FerrDb team 145 Ferroptosis FBXW7 HGNC:16712 FBXW7 plasmid induces ferroptosis. Human, mice FBXW7 :+: Ferroptosis Deduced 0 _NA_ Q969H0 31679460 _NA_ 2020/12/31 FerrDb team 146 Ferroptosis PANX1 HGNC:8599 Deletion protects against ferroptotic cell death. Silenced Panx1 expression significantly attenuated ferroptotic lipid peroxidation and iron accumulation induced by the ferroptosis inducer erastin. Human, mice PANX1 :-: HMOX1, HMOX1 :-: Ferroptosis, PANX1 :+: MAPK/ERK, MAPK/ERK :+: Ferroptinophagy, Ferroptinophagy :+: Ferroptosis Validated 0 _NA_ Q96RD7 31694915 _NA_ 2020/12/31 FerrDb team 147 Ferroptosis DNAJB6 HGNC:14888 Promotes ferroptosis in esophageal squamous cell carcinoma. Human, mice DNAJB6 :-: GPX4, GPX4 :-: Ferroptosis Predicted 0 _NA_ O75190 31701262 _NA_ 2020/12/31 FerrDb team 148 Ferroptosis BACH1 HGNC:935 Promotes ferroptosis by repressing the transcription of a subset of the erastin-induced protective genes. Mice BACH1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O14867 31740582 _NA_ 2020/12/31 FerrDb team 149 Ferroptosis ACSL4 HGNC:3571 Overexpression induced ferroptosis. The opposite results were observed when ACSL4 was silenced. Human ACSL4 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ O60488 31789401 _NA_ 2020/12/31 FerrDb team 150 Ferroptosis LONP1 HGNC:9479 Inhibition of LONP1 negatively regulates erastin-induced cell death. Human LONP1 :-: Nrf2/Keap1 pathway, Nrf2/Keap1 pathway :-: Ferroptosis, LONP1 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P36776 31822343 _NA_ 2021/4/11 FerrDb team 151 Ferroptosis CD82 HGNC:6210 This study identified that the high expression of the KAI1 gene promoted the occurrence of ferroptosis in PC cells through its extensive effect on FPN and GPX4. Human KAI1 :+: Ferroptosis Validated 0 _NA_ 33655331 KAI1 in article 2021/4/16 FerrDb team 152 Ferroptosis IL1B HGNC:5992 We observed that both IL-1β and FAC induced reactive oxygen species (ROS), and lipid ROS accumulation and ferroptosis related protein expression changes in chondrocytes. Ferrostatin-1, a ferroptosis specific inhibitor, attenuated the cytotoxicity, ROS and lipid-ROS accumulation and ferroptosis related protein expression changes induced by IL-1β and FAC and facilitated the activation of Nrf2 antioxidant system. Human, mice IL1B :+: ROS, ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 33376672 _NA_ 2021/5/17 FerrDb team 153 Ferroptosis CTSB HGNC:2527 Cathepsin B is an executioner of ferroptosis _NA_ CTSB :+: Ferroptosis Validated 0 _NA_ _NA_ 33340545 _NA_ 2021/5/18 FerrDb team 154 Ferroptosis POR HGNC:9208 The oxidoreductases POR and CYB5R1 are required for ferroptosis. Knockdown of POR in vivo protects ConA-induced ferroptotic liver damage Human, mice POR :+: hydrogen peroxide, hydrogen peroxide :+: PUFA peroxidation, PUFA peroxidation :+: Ferroptosis Validated 0 _NA_ _NA_ 33321093 _NA_ 2021/7/14 FerrDb team 155 Ferroptosis CYB5R1 HGNC:13397 The oxidoreductases POR and CYB5R1 are required for ferroptosis. Genetic knockout of POR and CYB5R1 decreases cellular hydrogen peroxide generation, preventing lipid peroxidation and ferroptosis. Human CYB5R1 :+: hydrogen peroxide, hydrogen peroxide :+: PUFA peroxidation, PUFA peroxidation :+: Ferroptosis Validated 0 _NA_ _NA_ 33321093 _NA_ 2021/7/14 FerrDb team 156 Ferroptosis ELOVL5 HGNC:21308 Biochemical and lipidomics analyses support the hypothesis that ELOVL5 and FADS1 are required to maintain intracellular levels of AA and AdA and promote ferroptosis. Human ELOVL5 :+: Arachidonic acid, Arachidonic acid :+: Ferroptosis Validated 0 _NA_ _NA_ 33288688 _NA_ 2021/7/21 FerrDb team 157 Ferroptosis FADS1 HGNC:3574 Biochemical and lipidomics analyses support the hypothesis that ELOVL5 and FADS1 are required to maintain intracellular levels of AA and AdA and promote ferroptosis. Human FADS1 :+: Arachidonic acid, Arachidonic acid :+: Ferroptosis Validated 0 _NA_ _NA_ 33288688 _NA_ 2021/7/21 FerrDb team 158 Ferroptosis ALOX12 HGNC:429 Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation. Mice ALOX12 :+: Lipid peroxide, Lipid peroxide :+: Ferroptosis Deduced 0 _NA_ _NA_ 33290842 _NA_ 2021/7/21 FerrDb team 159 Ferroptosis FBW7 HGNC:16712 Results revealed that FBW7 regulated lipid peroxidation and promoted ferroptosis, a non-apoptotic form of cell death. Human FBW7 :-: (NR4A1/SCD1), (NR4A1/SCD1) :+: SCD1, SCD1 :-: Ferroptosis Validated 0 _NA_ _NA_ 33271455 _NA_ 2021/8/2 FerrDb team 160 Ferroptosis PTEN HGNC:9588 Notably, we found that cancer cells carrying PIK3CA activating mutation or PTEN deletion appeared to be more resistant to RSL3. These mutations lead to the activation of the oncogenic PI3K-AKT signaling pathway. Therefore, sustained activation of the PI3K-AKT-mTOR pathway protects cancer cells from ferroptotic cell death. Human PTEN :-: PI3K-AKT pathway, PI3K-AKT pathway :-: Ferroptosis Deduced 0 _NA_ _NA_ 33229547 _NA_ 2021/8/2 FerrDb team 161 Ferroptosis NR1D1 HGNC:7962 Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced AKI in mice. Mice (NR1D1/RORE) :-: SLC7A11, SLC7A11 :-: Ferroptosis, (NR1D1/RORE) :-: HO1, HO1 :-: Ferroptosis Deduced 0 The homologous mice gene is validated. _NA_ 33068011 Rev-erb-α in article 2021/8/4 FerrDb team 162 Ferroptosis NR1D2 HGNC:7963 Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced AKI in mice. Mice (NR1D2/RORE) :-: SLC7A11, SLC7A11 :-: Ferroptosis, (NR1D2/RORE) :-: HO1, HO1 :-: Ferroptosis Deduced 0 The homologous mice gene is validated. _NA_ 33068011 Rev-erb-β in article 2021/8/4 FerrDb team 163 Ferroptosis TBK1 HGNC:11584 hTBK1-c.978T>A mutation significantly inhibited the proliferation of NSC-34 cells via inducing cell ferroptosis, while the effect of TBK1 mutation was notably reversed by Ferrostatin-1 or p62 siRNA. Mice TBK1-c.978T>A :+: KEAP1, KEAP1 :+: Ferroptosis Validated 0 TBK1-c.978T>A mutation. _NA_ 33312375 _NA_ 2021/8/9 FerrDb team 164 Ferroptosis IL6 HGNC:6018 IL-6 exposure caused cartilage cell ferroptosis by inducing cellular oxidative stress and disturbing iron homeostasis. Overexpressing miR-10a-5p suppressed IL-6R expression, and partially abolished IL-6-induced ferroptosis. Human, mice IL-6 :-: miR-10a-5p, miR-10a-5p :-: IL-6R, IL-6R :+: Ferroptosis Validated 0 _NA_ _NA_ 33166496 IL-6 in article 2021/8/11 FerrDb team 165 Ferroptosis USP7 HGNC:12630 USP7 promotes ferroptosis in the I/R-treated hearts via activation of p53/TfR1 pathway. Rat USP7 :+: p53/TfR1, p53/TfR1 :+: Ferroptosis Validated 0 _NA_ _NA_ 33157209 _NA_ 2021/8/21 FerrDb team 166 Ferroptosis miR-182-5p _NA_ In conclusion, we demonstrated that I/R induced upregulation of miR-182-5p and miR-378a-3p, leading to activation of ferroptosis in renal injury through downregulation of GPX4 and SLC7A11. Human, rat miR-182-5p :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 33116120 _NA_ 2021/8/23 FerrDb team 167 Ferroptosis miR-378a-3p _NA_ In conclusion, we demonstrated that I/R induced upregulation of miR-182-5p and miR-378a-3p, leading to activation of ferroptosis in renal injury through downregulation of GPX4 and SLC7A11. Human, rat miR-378a-3p :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ _NA_ 33116120 _NA_ 2021/8/23 FerrDb team 168 Ferroptosis CTSB HGNC:2527 Mechanistically, nuclear CTSB accumulation causes DNA damage and subsequent activation of the stimulator of interferon response CGAMP interactor 1 (STING1/STING)-dependent DNA sensor pathway, which ultimately leads to autophagy-dependent ferroptosis. Human, mice CTSB :+: DNA damage, DNA damage :+: DNA sensor pathway, DNA sensor pathway :+: Ferroptosis Deduced 0 _NA_ _NA_ 33268027 _NA_ 2021/8/25 FerrDb team 169 Ferroptosis ACSL4 HGNC:3571 Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia-reperfusion. Human, mice ACSL4 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ _NA_ 33070393 _NA_ 2021/8/27 FerrDb team 170 Ferroptosis ATF4 HGNC:786 We identify ATF4 as differentially expressed in P47 and S47 cells and show that ATF4 can reverse the redox status and rescue metabolism of S47 cells, as well as increase sensitivity to ferroptosis. Human, mice ATF4 :+: Ferroptosis Validated 0 _NA_ _NA_ 33055209 _NA_ 2021/8/30 FerrDb team 171 Ferroptosis BECN1 HGNC:1034 Beclin1 haploinsufficiency rescues low ambient temperature-induced cardiac remodeling and contractile dysfunction through inhibition of ferroptosis and mitochondrial injury. Mice BECN1 :+: Ferroptosis Deduced 0 _NA_ _NA_ 33058849 Beclin1 in article 2021/8/30 FerrDb team 172 Ferroptosis AQP3 HGNC:636 Further, we observed that aquaporin (AQP) 3, 5, and 8 bind nicotinamide-adenine dinucleotide phosphate oxidase 2 and regulate the permeability of extracellular H2O2, thereby contributing to ferroptosis. _NA_ (AQP3/NOX2) :+: H2O2, H2O2 :+: Ferroptosis Deduced 0 _NA_ _NA_ 33017631 _NA_ 2021/9/1 FerrDb team 173 Ferroptosis AQP5 HGNC:638 Further, we observed that aquaporin (AQP) 3, 5, and 8 bind nicotinamide-adenine dinucleotide phosphate oxidase 2 and regulate the permeability of extracellular H2O2, thereby contributing to ferroptosis. _NA_ (AQP5/NOX2) :+: H2O2, H2O2 :+: Ferroptosis Deduced 0 _NA_ _NA_ 33017631 _NA_ 2021/9/1 FerrDb team 174 Ferroptosis AQP8 HGNC:642 Further, we observed that aquaporin (AQP) 3, 5, and 8 bind nicotinamide-adenine dinucleotide phosphate oxidase 2 and regulate the permeability of extracellular H2O2, thereby contributing to ferroptosis. _NA_ (AQP8/NOX2) :+: H2O2, H2O2 :+: Ferroptosis Deduced 0 _NA_ _NA_ 33017631 _NA_ 2021/9/1 FerrDb team 175 Ferroptosis LINC00618 HGNC:20110 LINC00618 also accelerates ferroptosis by increasing the levels of lipid reactive oxygen species (ROS) and iron, two surrogate markers of ferroptosis, and decreasing the expression of solute carrier family 7 member 11 (SLC7A11) Human, mice LINC00618 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, LINC00618 :+: Iron, Iron :+: Ferroptosis, LINC00618 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ _NA_ 33002417 LINC00618 in article 2021/9/8 FerrDb team 176 Ferroptosis IREB2 HGNC:6115 Further studies have found that ART could lead to the accumulation of IRP 2 a in hepatic stellate cell by inhibiting the ubiquitination of it, thus inducing the increase of iron in HSC (hepatic stellate cell), which could product a large number of ROS (reactive oxide species), resulting the occurrence of ferroptosis in cells. Human IRP2 :+: Fe, Fe :+: ROS, ROS :+: Ferroptosis Deduced 0 _NA_ _NA_ 32947011 IRP2 in article 2021/9/13 FerrDb team 177 Ferroptosis MT1DP HGNC:7396 We found that ectopic expression of MT1DP sensitized A549 and H1299 cells to erastin-induced ferroptosis through downregulation of NRF2. Human MT1DP :+: miR-365a-3p, miR-365a-3p :-: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ _NA_ 32929075 _NA_ 2021/9/15 FerrDb team 178 Ferroptosis ACSL4 HGNC:3571 _NA_ Human ACSL4 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 179 Ferroptosis PEX10 HGNC:8851 Genome-wide CRISPR screens identify peroxisome components as contributors to ferroptosis susceptibility. Human, mice PEX10 :+: PUFA-ePLs, PUFA-ePLs :+: Ferroptosis Validated 0 _NA_ _NA_ 32939090 _NA_ 2021/9/26 FerrDb team 180 Ferroptosis KEAP1 HGNC:23177 _NA_ Human KEAP1 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 181 Ferroptosis AGPAT3 HGNC:326 _NA_ Human AGPAT3 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 182 Ferroptosis PEX12 HGNC:8854 Genome-wide CRISPR screens identify peroxisome components as contributors to ferroptosis susceptibility. Human PEX12 :+: PUFA-ePLs, PUFA-ePLs :+: Ferroptosis Validated 0 _NA_ _NA_ 32939090 _NA_ 2021/9/26 FerrDb team 183 Ferroptosis CHP1 HGNC:17433 _NA_ Human CHP1 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 184 Ferroptosis GPAT4 HGNC:20880 _NA_ Human AGPAT6 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 AGPAT6 in article; Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 185 Ferroptosis BRPF1 HGNC:14255 _NA_ Human BRPF1 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 186 Ferroptosis OSBPL9 HGNC:16386 _NA_ Human OSBPL9 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 187 Ferroptosis INTS2 HGNC:29241 _NA_ Human INTS2 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 188 Ferroptosis MMD HGNC:7153 _NA_ Human MMD :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 189 Ferroptosis CYP4F8 HGNC:2648 _NA_ Human CYP4F8 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 190 Ferroptosis MLLT1 HGNC:7134 _NA_ Human MLLT1 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 191 Ferroptosis TTPA HGNC:12404 _NA_ Human TTPA :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 192 Ferroptosis GRIA3 HGNC:4573 _NA_ Human GRIA3 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 193 Ferroptosis EPT1 _NA_ _NA_ Human EPT1 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 194 Ferroptosis POM121L12 HGNC:25369 _NA_ Human POM121L12 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 195 Ferroptosis LIG3 HGNC:6600 _NA_ Human, mice LIG3 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 196 Ferroptosis AEBP2 HGNC:24051 _NA_ Human AEBP2 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 197 Ferroptosis AGPS HGNC:327 Genome-wide CRISPR screens identify peroxisome components as contributors to ferroptosis susceptibility. Human AGPS :+: PUFA-ePLs, PUFA-ePLs :+: Ferroptosis Validated 0 _NA_ _NA_ 32939090 _NA_ 2021/9/26 FerrDb team 198 Ferroptosis CDCA3 HGNC:14624 _NA_ Human CDCA3 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 199 Ferroptosis PEX2 HGNC:9717 Genome-wide CRISPR screens identify peroxisome components as contributors to ferroptosis susceptibility. Human PEX2 :+: PUFA-ePLs, PUFA-ePLs :+: Ferroptosis Validated 0 _NA_ _NA_ 32939090 _NA_ 2021/9/26 FerrDb team 200 Ferroptosis LPCAT3 HGNC:30244 _NA_ Human LPCAT3 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 201 Ferroptosis PEX6 HGNC:8859 _NA_ Human PEX6 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 202 Ferroptosis TIMM9 HGNC:11819 _NA_ Human TIMM9 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 203 Ferroptosis DCAF7 HGNC:30915 _NA_ Human DCAF7 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 204 Ferroptosis LCE2C HGNC:29460 _NA_ Human LCE2C :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 205 Ferroptosis FAR1 HGNC:26222 Genome-wide CRISPR screens identify peroxisome components as contributors to ferroptosis susceptibility. Human FAR1 :+: PUFA-ePLs, PUFA-ePLs :+: Ferroptosis Validated 0 _NA_ _NA_ 32939090 _NA_ 2021/9/26 FerrDb team 206 Ferroptosis PHF21A HGNC:24156 _NA_ Human PHF21A :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 207 Ferroptosis SMAD7 HGNC:6773 _NA_ Human SMAD7 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 208 Ferroptosis LYRM1 HGNC:25074 _NA_ Human LYRM1 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 209 Ferroptosis AMN HGNC:14604 _NA_ Human AMN :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 210 Ferroptosis PEX3 HGNC:8858 Genome-wide CRISPR screens identify peroxisome components as contributors to ferroptosis susceptibility. Human PEX3 :+: PUFA-ePLs, PUFA-ePLs :+: Ferroptosis Validated 0 _NA_ _NA_ 32939090 _NA_ 2021/9/26 FerrDb team 211 Ferroptosis MTCH1 HGNC:17586 _NA_ Human MTCH1 :+: Ferroptosis Screened 0 _NA_ _NA_ 32939090 Top gene in genome-wide CRISPR screens 2021/9/26 FerrDb team 212 Ferroptosis ZEB1 HGNC:11642 CDH1 silencing or ZEB1 overexpression increased the susceptibility to ferroptosis, whereas CDH overexpression or ZEB1 silencing decreased the susceptibility, in vitro and in vivo. Human, mice ZEB1 :+: Ferroptosis Validated 0 _NA_ _NA_ 32896720 _NA_ 2021/9/27 FerrDb team 213 Ferroptosis SIRT1 HGNC:14929 Histone deacetylase SIRT1 gene silencing or pharmacological inhibition by EX-527 suppressed EMT and consequently decreased ferroptosis, whereas SIRT inducers, resveratrol and SRT1720, increased ferroptosis. Human, mice SIRT1 :+: EMT, EMT :+: Ferroptosis Validated 0 _NA_ _NA_ 32896720 _NA_ 2021/9/27 FerrDb team 214 Ferroptosis ACADSB HGNC:91 Overexpression of ACADSB inhibits CRC cell migration, invasion, and proliferation, while ACADSB knockdown has the opposite effect. More importantly, the study finds that ACADSB negatively regulates expression of glutathione reductase and glutathione peroxidase 4, the two main enzymes responsible for clearing glutathione (GSH) in CRC cells. Human ACADSB :-: GSR, GSR :-: Ferroptosis, ACADSB :-: GPX4, GPX4 :-: Ferroptosis, ACADSB :-: GSH, GSH :-: Ferroptosis Deduced 0 _NA_ _NA_ 32776663 _NA_ 2021/10/11 FerrDb team 215 Ferroptosis PVT1 HGNC:9709 PVT1 silencing or miR-214 overexpression significantly reduced infarct size and suppressed ferroptosis in vivo. Human, mice PVT1 :+: Ferroptosis Validated 0 _NA_ _NA_ 32827544 _NA_ 2021/10/13 FerrDb team 216 Ferroptosis hsa_circ_0008367 _NA_ These evidences suggested cIARS to be a positive regulator of ferroptosis in HCC cells. Human hsa_circ_0008367 :+: Ferroptosis Validated 0 _NA_ _NA_ 32802409 _NA_ 2021/10/15 FerrDb team 217 Ferroptosis SLC39A14 HGNC:20858 Loss of hepatic Slc39a14 protects against ferroptosis-induced liver fibrosis in Trf-LKO mice Mice SLC39A14 :+: Ferroptosis Validated 0 _NA_ _NA_ 32374849 _NA_ 2021/10/17 FerrDb team 218 Ferroptosis NCOA4 HGNC:7671 Additionally, NCOA4 expression was inhibited, which reduced degradation of ferritin and suppressed ferroptosis. Human NCOA4 :-: FTMT :-: Ferroptosis Deduced 0 _NA_ Q13772 32810738 _NA_ 2021/10/28 FerrDb team 219 Ferroptosis MAP3K11 HGNC:6850 Inhibition of MLK3 improves cardiac function and inhibits ferroptosis at week 8 of TAC. Mice MAP3K11 :+: Ferroptosis Validated 0 _NA_ Q16584 32710001 MLK3 in article. 2021/11/5 FerrDb team 220 Ferroptosis GSK3B HGNC:4617 Silence of GSK-3β blocked erastin-induced ferroptosis with less production of ROS and malondialdehyde (MDA) via upregulation of GPX4 and downregulation of arachidonate 15-lipoxygenase (Alox15), overexpression of GSK-3β enhanced erastin-triggered ferroptosis with elevated ROS and MDA Human GSK3B :+: Lipid ROS, Lipid ROS :+: Ferroptosis, GSK3B :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P49841 32642794 GSK-3β in article 2021/11/11 FerrDb team 221 Ferroptosis MAPK8 HGNC:6881 Knockdown of JNK results in loss of SAS‑induced cell proliferation inhibition and cell death. Human MAPK8 :+: Ferroptosis Validated 0 _NA_ P45983 32782585 JNK in article. 2021/11/16 FerrDb team 222 Ferroptosis BRD7 HGNC:14310 Upregulated BRD7 expression contributes to HSC ferroptosis. Human, mice BRD7 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, BRD7 :-: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q9NPI1 32863216 _NA_ 2021/11/18 FerrDb team 223 Ferroptosis TP53 HGNC:11998 Additionally, p53 knockdown and S392A mutant both can reduced the classical ferroptotic events by BRD7 knockin, including redox-active iron overload, lipid ROS accumulation, GSH depletion, and lipid peroxidation. Human, mice TP53 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, TP53 :-: GSH, GSH :-: Ferroptosis Validated 0 _NA_ P04637 32863216 p53 in article. 2021/11/18 FerrDb team 224 Ferroptosis SLC25A28 HGNC:23472 As expected, shRNA-mediated knockdown of SLC25A28 completely abolished the mitochondrial iron accumulation, and, in turn, impaired BRD7 knockin-enhanced ferroptotic cell death (Fig. 4G) and classical ferroptotic events. Human, mice SLC25A28 :+: mitochondrial iron accumulation, mitochondrial iron accumulation :+: Ferroptosis Validated 0 _NA_ Q96A46 32863216 _NA_ 2021/11/18 FerrDb team 225 Ferroptosis ACSL4 HGNC:3571 Inhibition of ACSL4 suppresses ferroptosis, inflammation and lipid accumulation triggered by arsenic. Rat ACSL4 :+: Ferroptosis Validated 0 _NA_ O60488 32593899 _NA_ 2021/11/18 FerrDb team 226 Ferroptosis MFN2 HGNC:16877 Thus, Mfn2 appeared to act as a driving role in the evolution of ferroptosis and NASH induced by NaAsO2. Rat MFN2 :+: 5-HETE, 5-HETE :+: Ferroptosis Validated 0 _NA_ O95140 32593899 _NA_ 2021/11/18 FerrDb team 227 Ferroptosis ACSL4 HGNC:3571 Knockdown of ACSL4 expression by specific siRNA/sgRNA significantly attenuated sorafenib-induced lipid peroxidation and ferroptosis in Huh7 cells, and also rescued sorafenibinduced inhibition of xenograft tumor growth in vivo. Human ACSL4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O60488 32541921 _NA_ 2021/11/21 FerrDb team 228 Ferroptosis SLC11A2 HGNC:10908 Overexpression of DMT1 promoted H/R-induced cell ferroptosis. Human SLC11A2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, SLC11A2 :+: ferrous iron, ferrous iron :+: Ferroptosis, SLC11A2 :+: iron deposition, iron deposition :+: Ferroptosis Validated 0 _NA_ P49281 32535745 DMT1 in article. 2021/11/21 FerrDb team 229 Ferroptosis ZFAS1 HGNC:33101 lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150- 5p/SLC38A1 axis. Human, rat ZFAS1 :+: SLC38A1, SLC38A1 :+: Ferroptosis, ZFAS1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 32453709 _NA_ 2021/12/1 FerrDb team 230 Ferroptosis SLC38A1 HGNC:13447 Mechanistically, silencing of lncRNA ZFAS1 attenuated ferroptosis and PF progression by lncRNA ZFAS1 acting as a competing endogenous RNA (ceRNA) and sponging miR-150-5p to downregulate SLC38A1 expression. Human, rat SLC38A1 :+: Ferroptosis Deduced 0 _NA_ Q9H2H9 32453709 _NA_ 2021/12/1 FerrDb team 231 Ferroptosis TSC1 HGNC:12362 Haploinsufficiency of Tsc1 in tubular cells prevents cisplatin-induced tubular cell death and AKI. Human, mice TSC1 :+: Ferroptosis Validated 0 Many studies revealed that apoptosis, necroptosis as well as ferroptosis all contribute to cisplatin-induced tubular cell death and AKI. Q92574 32404875 _NA_ 2021/12/2 FerrDb team 232 Ferroptosis PEBP1 HGNC:8630 We found that PEBP1 KO HT22 cells demonstrated very high resistance to RSL3-induced ferroptosis compared with wild-type control cells. Human PEBP1 :+: Ferroptosis Validated 0 _NA_ P30086 32513718 _NA_ 2021/12/2 FerrDb team 233 Ferroptosis TGFB1 HGNC:11766 Therefore, PLC/PRF/5 cells and Huh7 cells were vulnerable to RSL3 in the presence of TGF-β1. Human TGFB1 :-: xCT, xCT :+: GSH, GSH :-: Ferroptosis Deduced 0 _NA_ P01137 32471991 TGF-β1 in article 2021/12/3 FerrDb team 234 Ferroptosis SNCA HGNC:11138 Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Human SNCA :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P37840 32341450 Alpha synuclein in article. 2021/12/9 FerrDb team 235 Ferroptosis SIRT3 HGNC:14931 SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. Human, porcine SIRT3 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q9NTG7 32329068 _NA_ 2021/12/9 FerrDb team 236 Ferroptosis PRKAA2 HGNC:9377 Suppression of AMPK impairs SIRT3‐enhanced ferroptosis. Human, porcine PRKAA2 :+: Ferroptosis Validated 0 _NA_ P54646 32329068 AMPK in article. 2021/12/9 FerrDb team 237 Ferroptosis TFRC HGNC:11763 Knockdown of TFRC suppresses CP depletion-enhanced ferroptosis. Human TFRC :+: Fe2+, Fe2+ :+: Ferroptosis, TFRC :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P02786 32283255 _NA_ 2021/12/9 FerrDb team 238 Ferroptosis CGAS HGNC:21367 The CGAS-STING1 pathway promotes zalcitabine-induced ferroptosis. Human CGAS :+: MDA, MDA :+: Ferroptosis Validated 0 _NA_ Q8N884 32186434 _NA_ 2021/12/19 FerrDb team 239 Ferroptosis STING1 HGNC:27962 The CGAS-STING1 pathway promotes zalcitabine-induced ferroptosis. Human STING1 :+: MDA, MDA :+: Ferroptosis Validated 0 _NA_ Q86WV6 32186434 _NA_ 2021/12/19 FerrDb team 240 Ferroptosis HDDC3 HGNC:30522 Ferroptosis-inducing erastin or cystine deprivation elevates MESH1, whose overexpression depletes NADPH and sensitizes cells to ferroptosis, whereas MESH1 depletion promotes ferroptosis survival by sustaining the levels of NADPH and GSH and by reducing lipid peroxidation. Human HDDC3 :-: NADPH, NADPH :-: Ferroptosis, HDDC3 :-: GSH, GSH :-: Ferroptosis, HDDC3 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q8N4P3 32462112 MESH1 in article. 2021/12/22 FerrDb team 241 Ferroptosis MIR761 HGNC:37305 Additionally, circ-TTBK2 knockdown or miR-761 increase could retard cell proliferation, invasion, and promote ferroptosis in glioma cells. Human MIR761 :-: ITGB8, ITGB8 :-: Ferroptosis Validated 0 _NA_ _NA_ 32196629 _NA_ 2021/12/24 FerrDb team 242 Ferroptosis MDM2 HGNC:6973 MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling. Human MDM2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, MDM2 :-: PPARα, PPARα :-: Ferroptosis Validated 0 _NA_ Q00987 32079652 _NA_ 2021/12/30 FerrDb team 243 Ferroptosis MDM4 HGNC:6974 MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling. Human MDM4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, MDM4 :-: PPARα, PPARα :-: Ferroptosis Validated 0 _NA_ O15151 32079652 MDMX in article. 2021/12/30 FerrDb team 244 Ferroptosis ALOX15 HGNC:433 Indeed, knocking down (KD) of 15-LOX in M2 RAW 264.7 macrophages and EOC 20 cells resulted in significantly reduced sensitivity to ferroptosis triggered by RSL3 (Figs. 1e,f and supplementary Fig. 1e, f). Mice ALOX15 :+: Ferroptosis Validated 0 _NA_ P16050 32080625 15-LOX in article. 2021/12/30 FerrDb team 245 Ferroptosis POR HGNC:9208 These data indicate that POR is a key enzyme involved in the execution of ML210/RSL3-induced ferroptotic cell death in melanoma and ccRCC cells. Human POR :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P16435 32080622 _NA_ 2021/12/30 FerrDb team 246 Ferroptosis MIR214 HGNC:31591 MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells. Human miR-214 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, miR-214 :+: malondialdehyde, malondialdehyde :+: Ferroptosis, miR-214 :+: Fe2+, Fe2+ :+: Ferroptosis, miR-214 :-: glutathione, glutathione :-: Ferroptosis, miR-214 :-: ATF4, ATF4 :-: Ferroptosis Validated 0 _NA_ _NA_ 31960438 _NA_ 2021/12/30 FerrDb team 247 Ferroptosis DLD HGNC:2898 DLD links to ferroptosis induced by cystine deprivation or import inhibition. DLD gene silencing caused a significant reduction in cellular and lipid ROS levels induced by cystine deprivation but did not change intracellular GSH contents. Human DLD :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P09622 31931284 _NA_ 2021/12/30 FerrDb team 248 Ferroptosis LONP1 HGNC:9479 Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells. Human LONP1 :-: GPX4, GPX4 :-: Ferroptosis, LONP1 :+: ACSL4, ACSL4 :+: Ferroptosis, LONP1 :-: GSH, GSH :-: Ferroptosis, LONP1 :+: MDA, MDA :+: Ferroptosis, LONP1 :-: Nrf2, Nrf2 :+: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P36776 31822343 _NA_ 2022/1/7 FerrDb team 249 Ferroptosis ACSL4 HGNC:3571 ACSL4 suppresses glioma cells proliferation via activating ferroptosis. Human ACSL4 :-: GPX4, GPX4 :-: Ferroptosis, ACSL4 :+: 5-HETE, 5-HETE :+: Ferroptosis, ACSL4 :+: 12-HETE, 12-HETE :+: Ferroptosis, ACSL4 :+: 15-HETE, 15-HETE :+: Ferroptosis Validated 0 _NA_ O60488 31789401 _NA_ 2022/1/7 FerrDb team 250 Ferroptosis BACH1 HGNC:935 These results showed that BACH1 promoted ferroptosis in MEFs. Mice BACH1 :-: Gclm, Gclm :+: GSH, GSH :-: Ferroptosis, BACH1 :-: Src7a11, Src7a11 :+: GSH, GSH :-: Ferroptosis, BACH1 :-: Fth1, Fth1 :-: Fe2, Fe2 :+: Ferroptosis, BACH1 :-: Ftl1, Ftl1 :-: Fe2, Fe2 :+: Ferroptosis, BACH1 :-: Slc40a1, Slc40a1 :-: Fe2, Fe2 :+: Ferroptosis Validated 0 _NA_ O14867 31740582 _NA_ 2022/1/7 FerrDb team 251 Ferroptosis DNAJB6 HGNC:14888 DNAJB6 Promotes Ferroptosis in Esophageal Squamous Cell Carcinoma. Human DNAJB6a :+: Lipid ROS, Lipid ROS :+: Ferroptosis, DNAJB6a :-: GSH, GSH :-: Ferroptosis, DNAJB6a :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ O75190 31701262 _NA_ 2022/1/7 FerrDb team 252 Ferroptosis WWTR1 HGNC:24042 TAZ removal confers ferroptosis resistance, while TAZS89A overexpression sensitizes cells to ferroptosis. Human WWTR1 :+: ANGPTL4, ANGPTL4 :+: NOX2, NOX2 :+: Ferroptosis Validated 0 _NA_ Q9GZV5 31641008 TAZ in article. 2022/1/10 FerrDb team 253 Ferroptosis SIRT1 HGNC:14929 Intestinal SIRT1 Deficiency Inhibits Hepatic Ferroptosis in Ethanol-Administrated Mice. Mice SIRT1 :+: Fe/Fe2, Fe/Fe2 :+: Ferroptosis, SIRT1 :-: GSH, GSH :-: Ferroptosis, SIRT1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, SIRT1 :-: NADP+/NADPH, NADP+/NADPH :-: Ferroptosis Validated 0 _NA_ Q96EB6 31610175 _NA_ 2022/1/10 FerrDb team 254 Ferroptosis ATM HGNC:795 Taken together, we found ATM inhibition protects against ferroptosis by reducing the labile iron pool. Human ATM :-: FPN1, FPN1 :-: Fe, ATM :-: FTH1, FTH1 :-: Fe, ATM :-: FTL, FTL :-: Fe, Fe :+: Ferroptosis, ATM :-: GPX4, GPX4 :-: Ferroptosis, ATM :-: SLC40A1, SLC40A1 :-: Fe, Fe :+: Ferroptosis Validated 0 _NA_ Q13315 31320750 _NA_ 2022/1/10 FerrDb team 255 Ferroptosis PRKCA HGNC:9393 Similarly, genetic knockdown of PKCα significantly protected RMS cells from Erastin-induced cell death. Human PRKCA :+: Ferroptosis Validated 0 _NA_ P17252 31173656 PKCα in article. 2022/1/10 FerrDb team 256 Ferroptosis LGMN HGNC:9472 Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. Mice LGMN :+: Lipid ROS, Lipid ROS :+: Ferroptosis, LGMN :+: MDA, MDA :+: Ferroptosis, LGMN :+: Acsl4, Acsl4 :+: Ferroptosis, LGMN :+: Cox-2, Cox-2 :+: Ferroptosis, LGMN :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q99538 33431801 _NA_ 2022/1/19 FerrDb team 257 Ferroptosis ACSL4 HGNC:3571 ACSL4 promotes postischemic neuronal ferroptosis. Mice ACSL4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O60488 33444733 _NA_ 2022/1/19 FerrDb team 258 Ferroptosis TP53 HGNC:11998 p53 promotes RT-induced ferroptosis partly through antagonizing SLC7A11 induction. Human TP53 :-: SLC7A11, SLC7A11 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P04637 33927351 _NA_ 2022/1/26 FerrDb team 259 Ferroptosis IFNG HGNC:5438 IFNγ sensitized tumor cells to ferroptosis in vitro. Human IFNG :+: Lipid ROS, Lipid ROS :+: Ferroptosis, IFNG :-: System Xc-, System Xc- :-: Ferroptosis, IFNG :+: ACSL4, ACSL4 :+: Ferroptosis, IFNG :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P01579 34318944 IFNγ in article. 2022/1/26 FerrDb team 260 Ferroptosis SMPD1 HGNC:11120 Importantly, genetic activation of ASM increases ferroptosis in cancer cells induced by various FINs. Human SMPD1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, SMPD1 :-: System Xc-, System Xc- :-: Ferroptosis, SMPD1 :-: GSH, GSH :-: Ferroptosis, SMPD1 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P17405 33414455 ASM in article. 2022/1/26 FerrDb team 261 Ferroptosis MYCN HGNC:7559 MYCN confers cell sensitivity to ferroptosis upon GPX4 inhibition. Human MYCN :-: GPX4, GPX4 :-: Ferroptosis, MYCN :+: TFRC, TFRC :+: Fe2+, Fe2+ :+: Ferroptosis, MYCN :+: TFRC, TFRC :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P04198 34011924 _NA_ 2022/2/10 FerrDb team 262 Ferroptosis SLC11A2 HGNC:10908 Conversely, DMT1 knockdown by siRNA evidently blocked temozolomide-induced ferroptosis in TG905 cells. Human SLC11A2 :+: MDA, MDA :+: Ferroptosis, SLC11A2 :+: iron content, iron content :+: Ferroptosis, SLC11A2 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P49281 34427071 DMT1 in article. 2022/2/10 FerrDb team 263 Ferroptosis IFNA1 HGNC:5417 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA1 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01562 34385713 _NA_ 2022/2/10 FerrDb team 264 Ferroptosis IFNA2 HGNC:5423 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA2 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01563 34385713 _NA_ 2022/2/10 FerrDb team 265 Ferroptosis IFNA4 HGNC:5425 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA4 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P05014 34385713 _NA_ 2022/2/10 FerrDb team 266 Ferroptosis IFNA5 HGNC:5426 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA5 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01569 34385713 _NA_ 2022/2/10 FerrDb team 267 Ferroptosis IFNA6 HGNC:5427 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA6 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P05013 34385713 _NA_ 2022/2/10 FerrDb team 268 Ferroptosis IFNA7 HGNC:5428 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA7 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01567 34385713 _NA_ 2022/2/10 FerrDb team 269 Ferroptosis IFNA8 HGNC:5429 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA8 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P32881 34385713 _NA_ 2022/2/10 FerrDb team 270 Ferroptosis IFNA10 HGNC:5418 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA10 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01566 34385713 _NA_ 2022/2/10 FerrDb team 271 Ferroptosis IFNA13 HGNC:5419 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA13 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01562 34385713 _NA_ 2022/2/10 FerrDb team 272 Ferroptosis IFNA14 HGNC:5420 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA14 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01570 34385713 _NA_ 2022/2/10 FerrDb team 273 Ferroptosis IFNA16 HGNC:5421 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA16 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P05015 34385713 _NA_ 2022/2/10 FerrDb team 274 Ferroptosis IFNA17 HGNC:5422 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA17 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01571 34385713 _NA_ 2022/2/10 FerrDb team 275 Ferroptosis IFNA21 HGNC:5424 Together, our results demonstrate that the autoantibodies and the increased IFN-α in SLE sera downregulate the expression of GPX4 and lead to neutrophil ferroptosis. Human, mice IFNA21 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P01568 34385713 _NA_ 2022/2/10 FerrDb team 276 Ferroptosis SMG9 HGNC:25763 SMG9 drives ferroptosis by directly inhibiting GPX4 degradation. Human SMG9 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q9H0W8 34146907 _NA_ 2022/2/23 FerrDb team 277 Ferroptosis NR1D1 HGNC:7962 Kidney-specific loss of Rev-erbα attenuates AAI-induced ferroptosis and renal injury in mice. Mice NR1D1 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P20393 34673015 REV-ERBα in article. 2022/2/23 FerrDb team 278 Ferroptosis ACSL4 HGNC:3571 ACSL4 positively regulated ferroptosis in lung adenocarcinoma. Human ACSL4 :+: iron uptake, iron uptake :+: Ferroptosis, ACSL4 :+: Lipid ROS, Lpid ROS :+: Ferroptosis, ACSL4 :-: iron chelation, iron chelation :-: Ferroptosis Validated 0 _NA_ O60488 34053456 _NA_ 2022/2/24 FerrDb team 279 Ferroptosis PPARG HGNC:9236 PPARG drives ferroptosis in DCs. Mice PPARG :+: Ferroptosis Validated 0 _NA_ P37231 34478917 _NA_ 2022/2/24 FerrDb team 280 Ferroptosis TLR4 HGNC:11850 Inhibition of TLR4 prevents the activation of ferroptosis following HIBD. Human, rat TLR4 :-: SLC7A11, SLC7A11 :-: Ferroptosis, TLR4 :-: GPX4, GPX4 :-: Ferroptosis, TLR4 :+: oxidative stress, oxidative stress :+: Ferroptosis, TLR4 :+: mitochondrial injury, mitochondrial injury :+: Ferroptosis Validated 0 _NA_ O00206 34343528 _NA_ 2022/2/24 FerrDb team 281 Ferroptosis IL6 HGNC:6018 Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis. Human IL6 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, IL6 :+: Fe2, Fe2 :+: Ferroptosis Validated 0 _NA_ P05231 34402724 _NA_ 2022/2/24 FerrDb team 282 Ferroptosis miR-335 HGNC:31773 miR-335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease. Rat miR-335 :-: FTH1, FTH1 :-: iron release, iron release :+: Ferroptosis, miR-335 :-: FTH1, FTH1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, miR-335 :-: FTH1, FTH1 :+: mitochondrial membrane potential, mitochondrial membrane potential :-: Ferroptosis Validated 0 _NA_ _NA_ 33649797 _NA_ 2022/2/24 FerrDb team 283 Ferroptosis ATF3 HGNC:785 However, ATF3 elevated ferroptosis in SGC7901/DDP and BGC823/DDP cells. Human ATF3 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, ATF3 :+: MDA, MDA :+: Ferroptosis, ATF3 :-: GSH, GSH :-: Ferroptosis, ATF3 :-: Nrf2/Keap1 pathway, Nrf2/Keap1 pathway :-: Ferroptosis Validated 0 _NA_ P18847 34098867 _NA_ 2022/2/24 FerrDb team 284 Ferroptosis HMOX1 HGNC:5013 Excessive activation of HO-1 via Nrf2–SLC7A11–HO-1 hierarchy contributes to RPE ferroptosis. Human HMOX1 :+: cellular ferrous accumulation, cellular ferrous accumulation :+: Ferroptosis, HMOX1 :+: TFR, TFR :+: iron accumulation, iron accumulation :+: Ferroptosis, HMOX1 :-: SLC40A1, SLC40A1 :-: iron accumulation, iron accumulation :+: Ferroptosis Validated 0 _NA_ P09601 33895485 HO-1 in article. 2022/3/2 FerrDb team 285 Ferroptosis HMGB1 HGNC:4983 Collectively, these data revealed the suppression of HMGB1 prevents against glucose-induced ferroptosis in mesangial cells. Mice HMGB1 :+: lactate dehydrogenase, lactate dehydrogenase :+: Ferroptosis, HMGB1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, HMGB1 :+: ACSL4, ACSL4 :+: Ferroptosis, HMGB1 :-: GPX4, GPX4 :-: Ferroptosis, HMGB1 :-: Nrf2, Nrf2 :-: Ferroptosis Validated 0 _NA_ P09429 33565572 _NA_ 2022/3/2 FerrDb team 286 Ferroptosis EPAS1 HGNC:3374 D-mannose-induced downregulation of HIF-2α inhibits OA progression through suppressing chondrocyte ferroptosis. Mice EPAS1 :+: MDA, MDA :+: Ferroptosis, EPAS1 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q99814 34561933 HIF-2 α in article. 2022/3/2 FerrDb team 287 Ferroptosis SNX5 HGNC:14969 Super-enhancer-driven Sorting Nexin 5 expression promotes dopaminergic neuronal ferroptosis in Parkinson's disease models. Rat SNX5 :-: GPX4, GPX4 :-: Ferroptosis, SNX5 :+: Lipid peroxidation, Lipid peroxidation :+: Ferroptosis Validated 0 _NA_ Q9Y5X3 34134000 _NA_ 2022/3/3 FerrDb team 288 Ferroptosis PAQR3 HGNC:30130 PAQR3 aggravated ferroptosis in ALL. Human PAQR3 :+: MDA, MDA :+: Ferroptosis, PAQR3 :+: Fe, Fe :+: Ferroptosis, PAQR3 :-: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ Q6TCH7 33955706 _NA_ 2022/3/9 FerrDb team 289 Ferroptosis MICU1 HGNC:1530 MICU1 deficiency suppresses cold stress-induced ferroptosis. Human MICU1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9BPX6 33822458 _NA_ 2022/3/9 FerrDb team 290 Ferroptosis NOX4 HGNC:7891 NOX4 promotes ferroptosis by oxidative stress-induced lipid peroxidation in human astrocytes. Mice NOX4 :-: Mitochondrial respiration ATP production, Mitochondrial respiration ATP production :-: Impaired mitochondrial metabolism, Impaired mitochondrial metabolism :+: Oxidative stress-induced lipid peroxidation, Oxidative stress-induced lipid peroxidation :+: Ferroptosis Validated 0 _NA_ Q9NPH5 33774476 _NA_ 2022/3/9 FerrDb team 291 Ferroptosis TOR2A HGNC:11996 The data clearly demonstrated that salusin-β might be responsible for HG-induced ferroptosis via inhibiting the Nrf-2 signaling pathway. Human TOR2A :+: Lipid ROS, Lpid ROS :+: Ferroptosis, TOR2A :+: MDA, MDA :+: Ferroptosis, TOR2A :-: GSH, GSH :-: Ferroptosis, TOR2A :-: GPX4, GPX4 :-: Ferroptosis, TOR2A :-: SLC7A11, SLC7A11 :-: Ferroptosis, TOR2A :-: FTH-1, FTH-1 :-: Ferroptosis, TOR2A :-: NRF2, NRF2 :-: Ferroptosis Predicted 0 Salusins are found to be translated from an alternatively spliced mRNA of torsion dystonia-related gene (TOR2A). Proteolytic processing of prosalusin (216-amino acid) yields two related peptides of 28 and 20 amino acids, termed salusin-α and salusin-β, respectively. Q5JU69 34296310 _NA_ 2022/3/11 FerrDb team 332 Ferroptosis MIR375 HGNC:31868 MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis. Human MIR375 :-: SLC7A11, SLC7A11 :+: GSH, GSH :-: Ferroptosis, MIR375 :-: SLC7A11, SLC7A11 :+: cysteine, cysteine :-: Ferroptosis Validate 0 _NA_ _NA_ 34090492 _NA_ 2022/3/15 FerrDb team 333 Ferroptosis MAP3K14 HGNC:6853 NIK Acts Cell Autonomously to Promote Hepatocyte Ferroptosis. Mice MAP3K14 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validate 0 _NA_ Q99558 34558831 NIK in article. 2022/3/16 FerrDb team 334 Ferroptosis SIRT3 HGNC:14931 Collectively, our studies indicate that SIRT3 functions to inhibit AKT-dependent mitochondrial metabolism and EMT, leading to ferroptosis and tumor suppression. Human SIRT3 :+: ACSL4, ACSL4 :+: Ferroptosis Validate 0 _NA_ Q9NTG7 33872694 _NA_ 2022/3/16 FerrDb team 343 Ferroptosis CircKDM4C _NA_ CircKDM4C upregulates P53 by sponging hsa-let-7b-5p to induce ferroptosis in acute myeloid leukemia. Human, mice CircKDM4C :-: hsa-let-7b-5p, hsa-let-7b-5p :-: P53, P53 :+: Ferroptosis Validated 0 _NA_ _NA_ 33733556 _NA_ 2022/3/20 FerrDb team 344 Ferroptosis MIR324 HGNC:31767 miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549. Human MIR324 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 33662669 _NA_ 2022/3/21 FerrDb team 345 Ferroptosis QSOX1 HGNC:9756 QSOX1 promotes sorafenib-induced ferroptosis by downregulating NRF2 in HCC cells. Human QSOX1 :-: EGFR, EGFR :+: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ O00391 33770521 _NA_ 2022/3/21 FerrDb team 346 Ferroptosis MIB2 HGNC:30577 Knockdown of MIB2 alleviated neuron death and ferroptosis induced by sevoflurane exposure. Mice MIB2 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q96AX9 34121396 _NA_ 2022/3/21 FerrDb team 347 Ferroptosis CLTRN HGNC:29437 CLTRN overexpression can increase ferroptosis in HCC, and CLTRN can enhance the radiosensitivity of HCC cells through the ferroptosis pathway. Human CLTRN :+: Lipid ROS, Lipid ROS :+: Ferroptosis, CLTRN :+: Fe2+, Fe2+ :+: Ferroptosis, CLTRN :-: GSH, GSH :-: Ferroptosis, CLTRN :-: GPX4, GPX4 :-: Ferroptosis, CLTRN :-: SLC7A11, SLC7A11 :-: Ferroptosis, CLTRN :-: FTH1, FTH1 :-: Ferroptosis, CLTRN :+: ACSL4, ACSL4 :+: Ferroptosis, CLTRN :+: PTGS2, PTGS2 :+: Ferroptosis, CLTRN :+: NOX1, NOX1 :+: Ferroptosis Validated 0 _NA_ Q9HBJ8 33508374 _NA_ 2022/3/21 FerrDb team 348 Ferroptosis KLF2 HGNC:6347 Mechanistically, KLF2 deficiency is sufficient to inhibit ferroptosis on account of the impairment of transcriptional repression of GPX4 and thus promotes the migration and invasion of RCC cells. Human KLF2 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q9Y5W3 34520818 _NA_ 2022/3/21 FerrDb team 349 Ferroptosis MIR5096 HGNC:41611 Ectopically expressed miR-5096 causes ferroptotic cell death by elevating iron accumulation and oxidation of GSH but decreases MMP. Human MIR5096 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 MIR5096 record in HGNC has been withdrawn. _NA_ 34571083 _NA_ 2022/3/21 FerrDb team 350 Ferroptosis TFRC HGNC:11763 In conclusion, TFRC increased the iron content, mediated the release of ROS, activated mitophagy, and induced lipid peroxidation, which further promoted the ferroptosis of KGN cells. Mice TFRC :+: iron content, iron content :+: NOX1, NOX1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, TFRC :+: PINK1, PINK1 :+: mitophagy, mitophagy :+: ACSL4, ACSL4 :+: Ferroptosis, TFRC :+: PINK1, PINK1 :+: mitophagy, mitophagy :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P02786 34369274 _NA_ 2022/3/21 FerrDb team 351 Ferroptosis HOTAIR HGNC:33510 Overexpression of HOTAIR reversed the ferroptosis inhibition effects of PAN in hemin-treated neurons. Rat HOTAIR :-: UPF1, UPF1 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ _NA_ 33906483 Long non-coding RNA. 2022/3/21 FerrDb team 352 Ferroptosis H19 HGNC:4713 Over-expression of H19 suppressed cell viability and promoted ferroptosis of BMVECs. Human H19 :-: miR-106b-5p, miR-106b-5p :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ _NA_ 34288826 Long non-coding RNA. 2022/3/21 FerrDb team 353 Ferroptosis FOXO4 HGNC:7139 In addition, the inhibitory effects of ENPP2 on DOX-induced ferroptosis were significantly reduced by FoxO4 overexpression, as demonstrated by increased Fe2+ and lipid ROS activity levels, decreased SLC7A11, GPX4 and FPN1 expression, and increased NOX4 expression, which were observed following FoxO4 overexpression (Fig. 6A-C). Rat FOXO4 :-: ENNP2, ENNP2 :-: Ferroptosis Deduced 0 _NA_ P98177 34296293 _NA_ 2022/3/22 FerrDb team 354 Ferroptosis ELAVL1 HGNC:3312 Knockdown of ELAVL1 suppresses ferroptosis and H/R injury. Human ELAVL1 :+: autophagy, autophagy :+: Ferroptosis, ELAVL1 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q15717 33568052 _NA_ 2022/3/30 FerrDb team 355 Ferroptosis YTHDC2 HGNC:24721 YTHDC2 is an endogenous ferroptosis inducer in LUAD cells. Human YTHDC2 :-: system Xc-, system Xc- :-: Ferroptosis Validated 0 _NA_ Q9H6S0 33785413 _NA_ 2022/3/30 FerrDb team 356 Ferroptosis DDR2 HGNC:2731 DDR2 elevation in recurrent tumor cells contributes to its ferroptosis sensitivity. Human DDR2 :+: Ferroptosis Validated 0 _NA_ Q16832 33603168 _NA_ 2022/3/30 FerrDb team 357 Ferroptosis SLC39A7 HGNC:4927 The genetic and chemical inhibition of ZIP7 protect cells against ferroptosis. Human SLC39A7 :+: Ferroptosis Validated 0 _NA_ Q92504 33608508 ZIP7 in article. 2022/3/30 FerrDb team 358 Ferroptosis TRIM46 HGNC:19019 Taken together, these data demonstrate that TRIM46 directly facilitates HG-induced ferroptosis in HRCECs. Human TRIM46 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, TRIM46 :-: GPX4,GPX4 :-: Ferroptosis Validated 0 _NA_ Q7Z4K8 34487731 _NA_ 2022/3/30 FerrDb team 359 Ferroptosis ACSL1 HGNC:3569 These results demonstrate that ACSL1 promotes αESA-triggered cell death. Human ACSL1 :+: αESA, αESA :+: Ferroptosis Validated 0 _NA_ P33121 33854057 αESA induces ferroptosis in this article. 2022/3/30 FerrDb team 360 Ferroptosis KDM5A HGNC:9886 KDM5A inhibition decreases ferroptosis sensitivity in erPCC. Human KDM5A :-: MPC1, MPC1 :-: Ferroptosis Validated 0 _NA_ P29375 33741422 _NA_ 2022/3/30 FerrDb team 361 Ferroptosis TRIM21 HGNC:11312 Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. Mice TRIM21 :-: (p62/Keap1), (p62/Keap1) :-: Ferroptosis Validated 0 _NA_ P19474 34233258 _NA_ 2022/3/30 FerrDb team 362 Ferroptosis HMOX1 HGNC:5013 HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis. Human HMOX1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, HMOX1 :+: iron overload, iron overload :+: Ferroptosis Validated 0 _NA_ P09601 34508760 _NA_ 2022/3/30 FerrDb team 363 Ferroptosis DPEP1 HGNC:3002 Dpep1 knockdown ameliorates cisplatin-induced apoptosis and ferroptosis. Mice DPEP1 :+: Ferroptosis Validated 0 _NA_ P16444 34426578 _NA_ 2022/3/30 FerrDb team 364 Ferroptosis CYGB HGNC:16505 CYGB improved lipid oxidation and increased sensitivity to ferroptosis. Human CYGB :+: p53, p53 :+: YAP1, YAP1 :+: ACSL4, ACSL4 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q8WWM9 33611811 _NA_ 2022/3/30 FerrDb team 365 Ferroptosis IDO1 HGNC:6059 Inhibition of IDO prevents reoxygenation-induced ferroptosis. Mice IDO1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P14902 33899121 _NA_ 2022/3/30 FerrDb team 366 Ferroptosis GSTZ1 HGNC:4643 GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Human GSTZ1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, GSTZ1 :+: Fe2+, Fe2+ :+: Ferroptosis, GSTZ1 :-: GPX4, GPX4 :-: Ferroptosis, GSTZ1 :-: SLC7A11, SLC7A11 :-: Ferroptosis, GSTZ1 :-: FTL, FTL :-: Ferroptosis Validated 0 _NA_ O43708 33931597 _NA_ 2022/3/30 FerrDb team 367 Ferroptosis TP53 HGNC:11998 p53 promoted SPIO-Serum-induced ferroptosis. Human TP53 :-: SLC7A11, SLC7A11 :+: cysteine, cysteine :+: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P04637 33469287 _NA_ 2022/3/31 FerrDb team 368 Ferroptosis ACO1 HGNC:117 Overexpression of IRP1 significantly promotes erastin- and RSL3-induced ferroptosis. Human ACO1 :+: TFRC, TFRC :+: Ferroptosis, ACO1 :-: FPN, FPN :-: Ferroptosis, ACO1 :-: FTH1, FTH1 :-: Ferroptosis Validated 0 _NA_ P21399 34386079 IRP1 in article, with increasing oxygen concentrations, ACO1 is converted to IRP1. 2022/4/6 FerrDb team 369 Ferroptosis GJA1 HGNC:4274 Therefore, our results indicated that downregulation of Cx43 can inhibit ferroptosis by restoring the level of SLC7A11 in the system xc- transporter and alleviate cisplatin-induced AKI. Human, mice GJA1 :-: SLC7A11, SLC7A11 :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ P17302 34785303 Cx43 in article. 2022/4/6 FerrDb team 370 Ferroptosis IREB2 HGNC:6115 IRP2 Silencing Attenuated Hemin-Induced Ferroptosis in Primary Neurons in vitro. Mice IREB2 :-: FPN, FPN :-: Ferroptosis, IREB2 :-: FTH1, FTH1 :-: Ferroptosis Validated 0 _NA_ P48200 34307348 IRP2 in article. 2022/4/6 FerrDb team 371 Ferroptosis SLC7A11 HGNC:11059 SLC7A11 Induces Ferroptosis in NSCLC Cells. Human SLC7A11 :+: Ferroptosis Validated 0 SLC7A11 is a suppressor in most research. Q9UPY5 34722314 _NA_ 2022/4/6 FerrDb team 372 Ferroptosis PGRMC1 HGNC:16090 Our data suggest that PGRMC1 promotes ferroptosis by xCT inhibition in PCC. Mice PGRMC1 :-: xCT, xCT :-: Ferroptosis Validated 0 _NA_ O00264 34749765 _NA_ 2022/4/7 FerrDb team 373 Ferroptosis CIRBP HGNC:1982 Suppression of CIRBP inhibits ferroptosis in HK2 cells. Human CIRBP :+: ELAVL1, ELAVL1 :+: Ferroptosis Validated 0 _NA_ Q14011 34114349 _NA_ 2022/4/7 FerrDb team 374 Ferroptosis FAR1 HGNC:26222 Inactivation of FAR1 diminishes SFA-dependent ferroptosis. Human FAR1 :+: Ferroptosis Validated 0 _NA_ Q8WVX9 33731874 _NA_ 2022/4/7 FerrDb team 375 Ferroptosis circPSEN1 _NA_ Knockdown of circ-PSEN1 suppresses ferroptosis of HG-treated ARPE19 cells. Human circPSEN1 :-: miR-200b-3p, miR-200b-3p :+: CFL2, CFL2 :-: Ferroptosis Validated 0 _NA_ _NA_ 34903141 _NA_ 2022/4/7 FerrDb team 376 Ferroptosis USP11 HGNC:12609 Increased expression of USP11 promotes ferroptosis. Mice USP11 :+: ACSL4, ACSL4 :+: Ferroptosis, USP11 :-: GPX4, GPX4 :-: Ferroptosis, USP11 :-: FTH1, FTH1 :-: Ferroptosis Validated 0 _NA_ P51784 34839355 _NA_ 2022/4/7 FerrDb team 377 Ferroptosis STING1 HGNC:27962 STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion. Human STING1 :+: Ferroptosis Validated 0 _NA_ Q86WV6 34195205 _NA_ 2022/4/7 FerrDb team 378 Ferroptosis YAP HGNC:16262 Knockdown of YAP inhibits ferroptosis in HCC cells. Human YAP :+: Ferroptosis Validated 0 _NA_ P46937 34977009 _NA_ 2022/4/7 FerrDb team 379 Ferroptosis HMOX1 HGNC:5013 Finally, inhibition or induction of Hmox1 decreased or increased cardiac ferroptosis in SCD mice, respectively. Mice HMOX1 :+: Ferroptosis Validated 0 _NA_ P09601 34388243 _NA_ 2022/4/8 FerrDb team 380 Ferroptosis MIR135B HGNC:31760 miR-135b-3p Promotes Cardiomyocyte Ferroptosis by Targeting GPX4 and Aggravates Myocardial Ischemia/Reperfusion Injury. Rat MIR135B :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 34485394 _NA_ 2022/4/8 FerrDb team 381 Ferroptosis TRIM26 HGNC:12962 TRIM26 Overexpression Promotes HSCs Ferroptosis. Human TRIM26 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q12899 33869196 _NA_ 2022/4/8 FerrDb team 382 Ferroptosis YAP HGNC:16262 The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2. Human YAP :+: SKP2, SKP2 :+: TFRC, TFRC :+: Ferroptosis Validated 0 _NA_ P46937 33707306 _NA_ 2022/4/8 FerrDb team 383 Ferroptosis NDRG1 HGNC:7679 NDRG1 Activation Correlated with Ferroptosis Induction and EMT Inhibition. Human NDRG1 :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ Q92597 34917147 _NA_ 2022/4/8 FerrDb team 384 Ferroptosis MIR302A HGNC:31623 MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin. Human MIR302A :-: ferroportin, ferroportin :-: Ferroptosis Validated 0 _NA_ _NA_ 34181495 _NA_ 2022/4/8 FerrDb team 385 Ferroptosis ASMTL-AS1 HGNC:25811 In conclusion, we first demonstrated that ASMTL-AS1 positively regulated SAT1 to promote ferroptosis and could stabilize SAT1 mRNA via recruiting U2AF2, shedding a light on a novel molecular mechanism in LUAD progression. Human ASMTL-AS1 :+: SAT1, SAT1 :+: Ferroptosis Validated 0 _NA_ _NA_ 34658100 Long non-coding RNA. 2022/4/11 FerrDb team 386 Ferroptosis ZFAS1 HGNC:33101 Inhibition of ZFAS1 repressed ferroptosis in mice with DbCM‐ and HG‐treated cardiomyocytes. Mice ZFAS1 :-: miR‐150‐5p, miR‐150‐5p :+: CCND2, CCND2 :-: Ferroptosis Validated 0 _NA_ _NA_ 34609043 Long non-coding RNA. 2022/4/12 FerrDb team 387 Ferroptosis FADS2 HGNC:3575 We unexpectedly found that siRNA depletion of FADS2, like treatment with DFO or the ferroptosis inhibitor ferrostatin-1 (Fer1) (Dixon et al., 2012), protected cells from ferroptosis induced by the cystine/glutamate transporter (xCT) inhibitor erastin and the GPX4 inhibitor RSL3 in Huh-7.5 cells (Figures 5A, 5B, and S5A). Human FADS2 :+: Ferroptosis Validated 0 _NA_ O95864 34520742 _NA_ 2022/4/12 FerrDb team 388 Ferroptosis PIEZO1 HGNC:28993 Increased PIEZO1 expression or activation of PIEZO1 could activate Ca2+/calpain signaling, which promoted the cleavage VE-cadherin, thereby promoting ferroptosis. Human, mice PIEZO1 :+: (Ca2+/calpain), (Ca2+/calpain) :-: VE-cadherin, VE-cadherin :-: Ferroptosis Validated 0 _NA_ Q92508 34568428 _NA_ 2022/4/12 FerrDb team 389 Ferroptosis LIFR HGNC:6597 LIFR and SHP1 positively regulate ferroptosis while LCN2 negatively regulates ferroptosis. Human LIFR :+: SHP1, SHP1 :-: NF-κB signaling, NF-κB signaling :+: LCN2, LCN2 :-: Ferroptosis Validated 0 _NA_ P42702 34921145 _NA_ 2022/4/12 FerrDb team 390 Ferroptosis PTPN6 HGNC:9658 LIFR and SHP1 positively regulate ferroptosis while LCN2 negatively regulates ferroptosis. Human PTPN6 :-: NF-κB signaling, NF-κB signaling :+: LCN2, LCN2 :-: Ferroptosis Validated 0 _NA_ P29350 34921145 SHP1 in article. 2022/4/12 FerrDb team 942 Ferroptosis MIR15A HGNC:31543 Overexpression of miR-15a-5p aggravated ferroptosis in hypoxic cardiomyocytes. Mice MIR15A :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 34339707 _NA_ 2022/4/17 FerrDb team 943 Ferroptosis EGR1 HGNC:3238 Knockdown of Egr-1 alleviated ferroptosis in HL-1 cells under anoxic condition. Mice EGR1 :+: MIR15A, MIR15A :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P18146 34339707 _NA_ 2022/4/17 FerrDb team 944 Ferroptosis ADAM23 HGNC:202 Overexpression of ADAM23 suppressed tumorigenesis and promoted ferroptosis in esophageal carcinoma cells. Human ADAM23 :-: GPX4, GPX4 :-: Ferroptosis, ADAM23 :-: SLC7A11, SLC7A11 :-: Ferroptosis, ADAM23 :-: SLC3A2, SLC3A2 :-: Ferroptosis Validated 0 _NA_ O75077 35003396 _NA_ 2022/4/17 FerrDb team 945 Ferroptosis ARHGEF26-AS1 HGNC:41048 LncRNA ARHGEF26-AS1 Facilitated Ferroptosis but Restrained Cell Growth and Positively Regulated ADAM23 by Sponging miR-372-3p in ECC. Human ARHGEF26-AS1 :-: miR-372-3p, miR-372-3p :-: ADAM23, ADAM23 :+: Ferroptosis Validated 0 _NA_ _NA_ 35003396 Long non-coding RNA 2022/4/17 FerrDb team 946 Ferroptosis ACSL4 HGNC:3571 Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Suppresses Ferroptosis After Stroke. Mice ACSL4 :+: Ferroptosis Validated 0 _NA_ O60488 33889074 _NA_ 2022/4/17 FerrDb team 947 Ferroptosis CPEB1 HGNC:21744 CPEB1 enhances erastin-induced ferroptosis in gastric cancer cells by suppressing twist1 expression. Human CPEB1 :-: TWIST1, TWIST1 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q9BZB8 34184391 _NA_ 2022/4/18 FerrDb team 948 Ferroptosis COX4I2 HGNC:16232 Our research illustrated that the knockdown of Cox4i2 suppresses HHV7-induced RSC96 cell ferroptosis as well as apoptosis via the ERK signalling pathway. Rat COX4I2 :+: Ferroptosis Validated 0 _NA_ Q96KJ9 34026834 _NA_ 2022/4/18 FerrDb team 999 Ferroptosis lncRNA AABR07017145.1 _NA_ Importantly, we found that lncRNA AAB sponged and sequestered miR-30b-5p to induce the imbalance of MMP9/TIMP1, which enhanced the activation of transferrin receptor 1 (TFR-1) and then eventually led to the ferroptosis of CMECs. Rat lncRNA AABR07017145.1 :-: MiR-30b-5p, MiR-30b-5p :-: TIMP1, TIMP1 :+: Ferroptosis Validated 0 _NA_ _NA_ 34938604 lncRNA AAB in article. 2022/4/25 FerrDb team 1000 Ferroptosis TIMP1 HGNC:11820 Silencing TIMP1 inhibits CMEC ferroptosis by downregulation of TFR-1. Rat TIMP1 :+: TFR-1, TFR-1 :+: Ferroptosis Validated 0 _NA_ P01033 34938604 _NA_ 2022/4/25 FerrDb team 1001 Ferroptosis MIR15A HGNC:31543 miR-15a-3p promotes ferroptosis through GPX4. Human MIR15A :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 34727409 _NA_ 2022/4/25 FerrDb team 1002 Ferroptosis KDM6B HGNC:29012 JMJD3 deficiency alleviates lipopolysaccharide‑induced acute lung injury by inhibiting alveolar epithelial ferroptosis in a Nrf2‑dependent manner. Human, mice KDM6B :-: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ O15054 34542160 JMJD3 in article. 2022/4/25 FerrDb team 1003 Ferroptosis NCOA4 HGNC:7671 Both in vivo and in vitro, NCOA4 deletion notably abrogated ferritinophagy caused by I/R injury and thus inhibited ferroptosis. Mice NCOA4 :+: Ferroptosis Validated 0 _NA_ Q13772 34634471 _NA_ 2022/4/25 FerrDb team 1004 Ferroptosis GSK3B HGNC:4617 GSK-3β knockdown suppresses erastin-induced ferroptosis. Human GSK3B :+: labile iron, labile iron :+: Ferroptosis Validated 0 _NA_ P49841 34732689 _NA_ 2022/4/25 FerrDb team 1005 Ferroptosis IFNG HGNC:5438 Interferon-γ induces retinal pigment epithelial cell Ferroptosis by a JAK1-2/STAT1/SLC7A11 signaling pathway in Age-related Macular Degeneration. Mice IFNG :+: (JAK1-2/STAT1/SLC7A11), (JAK1-2/STAT1/SLC7A11) :+: Ferroptosis, IFNG :-: SLC40A1, SLC40A1 :-: Ferroptosis Validated 0 _NA_ P01579 34741776 _NA_ 2022/4/25 FerrDb team 1006 Ferroptosis METTL14 HGNC:29330 METTL14 promotes doxorubicin-induced ferroptosis in cardiomyocytes. Human, rat METTL14 :+: KCNQ1OT1, KCNQ1OT1 :-: miR-7-5p, miR-7-5p :-: Ferroptosis Validated 0 _NA_ Q9HCE5 34648132 _NA_ 2022/5/5 FerrDb team 1007 Ferroptosis CHAC1 HGNC:28680 CHAC1 promotes ferroptosis. Human CHAC1 :-: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q9BUX1 34345279 _NA_ 2022/5/5 FerrDb team 1008 Ferroptosis MIB1 HGNC:21086 The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis. Human MIB1 :-: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ Q86YT6 34670864 _NA_ 2022/5/5 FerrDb team 1009 Ferroptosis KDM5C HGNC:11114 KDM5C suppresses tumorigenicity largely by promoting ferroptosis. Human, mice KDM5C :+: Ferroptosis Validated 0 _NA_ P41229 34522206 _NA_ 2022/5/9 FerrDb team 1010 Ferroptosis ACSL4 HGNC:3571 Downregulation of ACSL4 inhibited sev-induced ferroptosis. Human ACSL4 :-: (AMPK/mTOR), (AMPK/mTOR) :-: Ferroptosis Validated 0 _NA_ O60488 34734006 _NA_ 2022/5/11 FerrDb team 1011 Ferroptosis MEG3 HGNC:14575 Inhibition of Meg3 conferred protection to RBMVECs against OGD + HG-induced ferroptosis. Mice MEG3 :+: p53, p53 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 34587716 _NA_ 2022/5/11 FerrDb team 1012 Ferroptosis CCDC6 HGNC:18782 The genetic depletion of CCDC6, by shCCDC6, made the NTERA-2 cells resistant to erastin-induced ferroptosis (Fig. 5 A). Human, mice CCDC6 :-: (xCT/SLC7A11), (xCT/SLC7A11) :-: Ferroptosis Validated 0 _NA_ Q16204 34841108 _NA_ 2022/5/11 FerrDb team 1013 Ferroptosis ATF3 HGNC:785 Taken together, ATF3 contributes to brucine-induced glioma cell ferroptosis via increasing H2O2 and iron. Human ATF3 :+: NOX4, NOX4 :+: H2O2, H2O2 :+: Ferroptosis, ATF3 :+: SOD1, SOD1 :+: H2O2, H2O2 :+: Ferroptosis, ATF3 :-: SLC7A11, SLC7A11 :-: H2O2, H2O2 :+: Ferroptosis Validated 0 _NA_ P18847 34112960 _NA_ 2022/5/11 FerrDb team 1014 Ferroptosis IREB2 HGNC:6115 IRP2 activation increases intracellular Fe+2 pool and sensitize cells to ferroptosis. Human IREB2 :+: Ferroptosis Validated 0 _NA_ P48200 34039609 IRP2 in article. 2022/5/15 FerrDb team 1015 Ferroptosis CFL1 HGNC:1874 Cofilin1 downregulation attenuates glutamate- and erastin-induced cell death. Mice CFL1 :+: Ferroptosis Validated 0 _NA_ P23528 34657120 cofilin1 in article. 2022/5/16 FerrDb team 1016 Ferroptosis ALOXE3 HGNC:13743 ALOXE3 knockdown renders GBM cells resistant to p53-induced ferroptosis. Mice ALOXE3 :+: Ferroptosis Validated 0 _NA_ Q9BYJ1 33579899 _NA_ 2022/5/24 FerrDb team 1017 Ferroptosis MIR539 HGNC:32529 miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE. Human MIR539 :-: TIPE, TIPE :-: (SAPK/JNK), (SAPK/JNK) :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 34601499 _NA_ 2022/5/24 FerrDb team 1018 Ferroptosis KMT2D HGNC:7133 Mll4 deficiency impairs ferroptosis via rewired gene expression. Mice KMT2D :+: ALOX12, ALOX12 :+: Ferroptosis Validated 0 _NA_ O14686 34890228 MLL4 in article. 2022/5/24 FerrDb team