id rcd symbol hgncid evidence testin pathway confidence experiments caution uniprotac pmid remark latestupdate datasource 1 Ferroptosis SLC7A11 HGNC:11059 Silencing of SLC7A11 sensitized HT-1080 cells to erastin-induced death, whereas transfection of HT-1080 cells with a plasmid encoding SLC7A11 conferred protection from erastin- and sulfasalazine-induced death. Human SLC7A11 :+: Cystine, Cystine :-: Ferroptosis Validated 0 _NA_ Q9UPY5 22632970 _NA_ 2020/12/31 FerrDb team 2 Ferroptosis GPX4 HGNC:4556 RNAi-mediated GPX4 knockdown induces ferroptosis. Human, mice GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P36969 24439385 _NA_ 2020/12/31 FerrDb team 3 Ferroptosis AKR1C1 HGNC:384 Up-regulated in DU-145 erastin-resistant clones. Participate in the detoxification of toxic lipid metabolites. May confer partial resistance to erastin by enhancing the detoxification of reactive aldehydes generated downstream of the oxidative destruction of the plasma membrane during ferroptosis. Human AKR1C1 :-: Ferroptosis Validated 0 _NA_ Q04828 24844246 _NA_ 2020/12/31 FerrDb team 4 Ferroptosis AKR1C2 HGNC:385 Up-regulated in DU-145 erastin-resistant clones. Participate in the detoxification of toxic lipid metabolites. May confer partial resistance to erastin by enhancing the detoxification of reactive aldehydes generated downstream of the oxidative destruction of the plasma membrane during ferroptosis. Human AKR1C2 :-: Ferroptosis Validated 0 _NA_ P52895 24844246 _NA_ 2020/12/31 FerrDb team 5 Ferroptosis AKR1C3 HGNC:386 Up-regulated in DU-145 erastin-resistant clones. Participate in the detoxification of toxic lipid metabolites. May confer partial resistance to erastin by enhancing the detoxification of reactive aldehydes generated downstream of the oxidative destruction of the plasma membrane during ferroptosis. Human AKR1C3 :-: Ferroptosis Validated 0 _NA_ P42330 24844246 _NA_ 2020/12/31 FerrDb team 6 Ferroptosis GPX4 HGNC:4556 Knockout of glutathione peroxidase 4 (Gpx4) causes cell death in a pathologically relevant form of ferroptosis. Knockdown renders cells more sensitive to ferroptosis-inducing agents. Human, mice GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P36969 25402683 _NA_ 2020/12/31 FerrDb team 7 Ferroptosis RB1 HGNC:9884 Rb knock-down cells exposed to sorafenib encounter ferroptosis. Lack of Rb sensitized HCC cells to the induction of ferroptosis. Human, mice RB1 :-: Ferroptosis Validated 0 _NA_ P06400 25444922 _NA_ 2020/12/31 FerrDb team 8 Ferroptosis HSPB1 HGNC:5246 Knockdown of HSF1 and HSPB1 enhances erastin-induced ferroptosis, whereas heat shock pretreatment and overexpression of HSPB1 inhibits erastin-induced ferroptosis. Human, mice HSPB1 :-: Ferroptosis Validated 0 _NA_ P04792 25728673 _NA_ 2020/12/31 FerrDb team 9 Ferroptosis HSF1 HGNC:5224 Knockdown of HSF1 and HSPB1 enhances erastin-induced ferroptosis, whereas heat shock pretreatment and overexpression of HSPB1 inhibits erastin-induced ferroptosis. Human, mice HSF1 :-: Ferroptosis Validated 0 _NA_ Q00613 25728673 _NA_ 2020/12/31 FerrDb team 10 Ferroptosis SLC7A11 HGNC:11059 Overexpressed in human cancer specimens. Overexpression inhibits ROS-induced ferroptosis. Human, mice SLC7A11 :+: Cystine, Cystine :-: Ferroptosis Validated 0 _NA_ Q9UPY5 25799988 _NA_ 2020/12/31 FerrDb team 11 Ferroptosis GPX4 HGNC:4556 Ex vivo, Gpx4-deficient T cells rapidly accumulated membrane lipid peroxides and concomitantly underwent cell death driven by ferroptosis. Mice GPX4 :-: Ferroptosis Validated 0 _NA_ P36969 25824823 _NA_ 2020/12/31 FerrDb team 12 Ferroptosis GCLC HGNC:4311 RNAi knockdown sensitized cell death induced by cystine starvation. Mice GCLC :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ P48506 26166707 _NA_ 2020/12/31 FerrDb team 13 Ferroptosis SLC7A11 HGNC:11059 Overexpression of SLC7A11 considerably abrogated ferroptosis. Human SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q9UPY5 26218928 _NA_ 2020/12/31 FerrDb team 14 Ferroptosis NFE2L2 HGNC:7782 NRF2 plays a central role in protecting hepatocellular carcinoma (HCC) cells against ferroptosis Human, mice NFE2L2 :+: (NQO1/HMOX1/FTH1), (NQO1/HMOX1/FTH1) :-: Ferroptosis Validated 0 _NA_ Q16236 26403645 NRF2 in article 2020/12/31 FerrDb team 15 Ferroptosis SQSTM1 HGNC:11280 The interaction between p62 and Keap1 increased following erastin and sorafenib treatment. Knockdown of p62 suppressed NRF2 expression and promoted growth inhibition with increased ferroptotic events including GSH depletion, lipid ROS production, and an increase of iron levels. Human, mice SQSTM1 :-: KEAP1, KEAP1 :-: NFE2L2, NFE2L2 :-: Ferroptosis Validated 0 _NA_ Q13501 26403645 p62 in article. 2020/12/31 FerrDb team 16 Ferroptosis NQO1 HGNC:2874 Knockdown of p62, quinone oxidoreductase‐1, heme oxygenase‐1, and ferritin heavy chain‐1 by RNA interference in HCC cells promoted ferroptosis in response to erastin and sorafenib. Human, mice NQO1 :-: Ferroptosis Validated 0 _NA_ P15559 26403645 _NA_ 2020/12/31 FerrDb team 17 Ferroptosis HMOX1 HGNC:5013 Knockdown of p62, quinone oxidoreductase‐1, heme oxygenase‐1, and ferritin heavy chain‐1 by RNA interference in HCC cells promoted ferroptosis in response to erastin and sorafenib. Human, mice HMOX1 :-: Ferroptosis Validated 0 Article (PMID 26405158) suggests it a driver. P09601 26403645 HO1 in article 2020/12/31 FerrDb team 18 Ferroptosis FTH1 HGNC:3976 Knockdown of p62, quinone oxidoreductase‐1, heme oxygenase‐1, and ferritin heavy chain‐1 by RNA interference in HCC cells promoted ferroptosis in response to erastin and sorafenib. Human, mice FTH1 :-: Ferroptosis Validated 0 _NA_ P02794 26403645 _NA_ 2020/12/31 FerrDb team 19 Ferroptosis MUC1 HGNC:7508 MUC1-C (C-terminal subunit) blocks erastin-induced ferroptosis and induces increases in GSH. Human MUC1 :+: System Xc-, System Xc- :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ P15941 26930718 _NA_ 2020/12/31 FerrDb team 20 Ferroptosis SLC3A2 HGNC:11026 Required for in vitro cell survival because of its role in protecting cells from ferroptosis. Mice SLC3A2 :+: System Xc-, System Xc- :-: Ferroptosis Validated 0 _NA_ P08195 26945935 CD98hc in article 2020/12/31 FerrDb team 21 Ferroptosis MT1G HGNC:7399 A negative regulator of ferroptosis in HCC cells. Knockdown of MT‐1G by RNA interference increases glutathione depletion and lipid peroxidation, which contributes to sorafenib‐induced ferroptosis. Human, mice MT1G :-: Ferroptosis Validated 0 _NA_ P13640 27015352 MT‐1G in article 2020/12/31 FerrDb team 22 Ferroptosis NFE2L2 HGNC:7782 Required for sorafenib‐induced expression of MT‐1G which is a ferroptosis suppressor. Human NFE2L2 :+: MT1G, MT1G :-: Ferroptosis Deduced 0 Its ability to induce MT1G was validated, but its role in ferroptosis needs validation. Q16236 27015352 NRF2 in article 2020/12/31 FerrDb team 23 Ferroptosis SLC40A1 HGNC:10909 Involved in siramesine and lapatinib-induced ferroptotic cell death. Its expression is decreased after treatment with siramesine alone or in combination with lapatinib. Overexpression FPN resulted in decreased ROS and cell death whereas knockdown of FPN increased cell death after siramesine and lapatinib treatment. Human SLC40A1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9NP59 27441659 Ferroportin-1 (FPN) in article 2020/12/31 FerrDb team 24 Ferroptosis SLC7A11 HGNC:11059 Knockdown increased cell death. Human SLC7A11 :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q9UPY5 27441659 _NA_ 2020/12/31 FerrDb team 25 Ferroptosis GPX4 HGNC:4556 Knockdown increased cell death. Human GPX4 :-: Ferroptosis Validated 0 _NA_ P36969 27441659 _NA_ 2020/12/31 FerrDb team 26 Ferroptosis SLC7A11 HGNC:11059 Inhibition induces ferroptosis. Silencing of the SLC7A11 gene increases the cisplatin sensitivity of resistant HNC cells. Human, mice SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q9UPY5 27477897 _NA_ 2020/12/31 FerrDb team 27 Ferroptosis CISD1 HGNC:30880 Genetic inhibition of CISD1 contributes to erastin-induced ferroptosis. Stabilization of the iron sulfur cluster of CISD1 inhibits ferroptosis. Human CISD1 :-: Mitochondrial lipid ROS, Mitochondrial lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9NZ45 27510639 _NA_ 2020/12/31 FerrDb team 28 Ferroptosis SLC7A11 HGNC:11059 Elevated levels of expression are resistant to erastin-induced ferroptosis. Repression of SLC7A11 expression by p53 sensitized cells to undergo erastin-induced ferroptosis. Human SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q9UPY5 27705786 _NA_ 2020/12/31 FerrDb team 29 Ferroptosis FANCD2 HGNC:3585 Inhibits erastin-induced ferroptosis. Plays a novel role in the negative regulation of ferroptosis. Mice FANCD2 :-: Ferroptosis Validated 0 _NA_ Q9BXW9 27773819 _NA_ 2020/12/31 FerrDb team 30 Ferroptosis GPX4 HGNC:4556 Protects lipid peroxidation. Cell damage induced by GPx4 ablation is involved in ferroptosis. Human GPX4 :-: LDH, LDH :+: Ferroptosis Validated 0 _NA_ P36969 27964880 _NA_ 2020/12/31 FerrDb team 31 Ferroptosis NFE2L2 HGNC:7782 Nrf2 activation contributes to the resistance of HNCs to artesunate-induced ferroptosis. Nrf2 inhibition sensitizes head and neck cancer cells to artesunate-induced ferroptosis. Mice NFE2L2 :-: Ferroptosis Validated 0 _NA_ Q16236 28012440 NRF2 in article 2020/12/31 FerrDb team 32 Ferroptosis FTMT HGNC:17345 Overexpression significantly inhibited erastin-induced ferroptosis. Mice, fly FTMT :-: Labile iron pool, Labile iron pool :+: Ferroptosis Validated 0 _NA_ Q8N4E7 28066232 _NA_ 2020/12/31 FerrDb team 33 Ferroptosis HSPA5 HGNC:5238 Negatively regulates ferroptosis. Suppression of HSPA5 expression increased erastin-induced death. Overexpressed HSPA5 inhibited erastin-induced ferroptotic cell death. Human, mice HSPA5 :+: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P11021 28130223 _NA_ 2020/12/31 FerrDb team 34 Ferroptosis ATF4 HGNC:786 Inhibition of ATF4 expression increased erastin-induced cell death. ATF4 results in the induction of HSPA5, which in turn protects against GPX4 protein degradation and subsequent ferroptosis. Human ATF4 :+: HSPA5, HSPA5 :+: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P18848 28130223 _NA_ 2020/12/31 FerrDb team 35 Ferroptosis SLC7A11 HGNC:11059 Slc7a11 deletion increases susceptibility to iron overload-induced ferroptosis. Mice SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q9UPY5 28195347 _NA_ 2020/12/31 FerrDb team 36 Ferroptosis GPX4 HGNC:4556 Ferroptosis drives neurodegeneration in Gpx4BIKO mice. Mice GPX4 :-: Ferroptosis Validated 0 _NA_ P36969 28212525 _NA_ 2020/12/31 FerrDb team 37 Ferroptosis GPX4 HGNC:4556 Downregulation conferred increased sensitivity to ferroptosis following cystine deprivation. Human GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P36969 28297659 _NA_ 2020/12/31 FerrDb team 38 Ferroptosis HMOX1 HGNC:5013 Demonsrates antiferroptotic role. HO-1 deficiency promotes erastin-induced ferroptosis. Mice HMOX1 :-: Ferroptosis Validated 0 Article (PMID 26405158) suggests it a driver. P09601 28515173 HO-1 in article 2020/12/31 FerrDb team 39 Ferroptosis ATF4 HGNC:786 ATF4 expression induces acquired cell death resistance. ATF4 knockdown renders cells susceptible for ferroptosis. Human ATF4 :+: xCT, xCT :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P18848 28553953 _NA_ 2020/12/31 FerrDb team 40 Ferroptosis NFE2L2 HGNC:7782 Nrf2 over expression promotes resistance to ferroptosis. Human, rat NFE2L2 :+: xCT, xCT :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q16236 28805788 Nrf2 in article 2020/12/31 FerrDb team 41 Ferroptosis TP53 HGNC:11998 Inhibits ferroptosis in human colorectal cancer (CRC) cells. Loss of TP53 restored erastin sensitivity. Inhibits cell death induction by erastin in human CRC cells. Human, mice TP53 :+: Nucleus DPP4, Nucleus DPP4 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 Promotes ferroptosis via a transcription-dependent mechanism in non-CRC cells. P04637 28813679 _NA_ 2020/12/31 FerrDb team 42 Ferroptosis SLC7A11 HGNC:11059 Knockdown sensitized cells to erastin. Human SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q9UPY5 28813679 _NA_ 2020/12/31 FerrDb team 43 Ferroptosis HELLS HGNC:4861 LSH inhibits ferroptosis by decreasing the intracellular levels of iron and lipid ROS. Human, mice HELLS :+: GLUT1, HELLS :+: SCD, HELLS :+: FADS2, GLUT1 :-: Ferroptosis, SCD :-: Ferroptosis, FADS2 :-: Ferroptosis Validated 0 _NA_ Q9NRZ9 28900510 LSH in article 2020/12/31 FerrDb team 44 Ferroptosis SCD HGNC:10571 Depletion of the SCD1 and FADS2 metabolic genes induces ferroptosis. Human SCD :-: Ferroptosis Validated 0 _NA_ O00767 28900510 SCD1 in article 2020/12/31 FerrDb team 45 Ferroptosis FADS2 HGNC:3575 Depletion of the SCD1 and FADS2 metabolic genes induces ferroptosis. Human FADS2 :-: Ferroptosis Validated 0 _NA_ O95864 28900510 _NA_ 2020/12/31 FerrDb team 46 Ferroptosis SRC HGNC:11283 Src-STAT3 activation renders the cell unable to undergo to ferroptosis. Src inhibition decreased cell viability significantly, and that loss of viability was rescued by ferroptosis inhibitors. Human SRC :+: STAT3, STAT3 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ P12931 28972104 _NA_ 2020/12/31 FerrDb team 47 Ferroptosis STAT3 HGNC:11364 Src-STAT3 activation renders the cell unable to undergo to ferroptosis. Human STAT3 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ P40763 28972104 _NA_ 2020/12/31 FerrDb team 48 Ferroptosis NFE2L2 HGNC:7782 ARF-mediated ferroptosis was largely abrogated by co-expression of NRF2. Human, mice NFE2L2 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q16236 28985506 NRF2 in article 2020/12/31 FerrDb team 49 Ferroptosis PML HGNC:9113 PML expression turned cells highly resistant to ferroptosis. Human PML :-: Ferroptosis Validated 0 _NA_ P29590 29081404 _NA_ 2020/12/31 FerrDb team 50 Ferroptosis MTOR HGNC:3942 Necessary and sufficient to protect cardiomyocyte cells against ferroptotic cell death. mTOR overexpression suppressed ferroptotic cell death, whereas mTOR deletion exaggerated cell death. Mice MTOR :-: Ferroptosis Validated 0 _NA_ P42345 29127238 _NA_ 2020/12/31 FerrDb team 51 Ferroptosis NFS1 HGNC:15910 Suppression of NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis in vitro and slow tumour growth. Suppression of NFS1 predisposes cancer cells to ferroptosis. Human NFS1 :-: TFRC, TFRC :+: Ferroptosis Validated 0 _NA_ Q9Y697 29168506 _NA_ 2020/12/31 FerrDb team 52 Ferroptosis TP63 HGNC:15979 Delta Np63 alpha can inhibit ferroptosis independent of p53. Overexpression protects cells from ferroptosis-inducing agents. Human TP63 :-: Ferroptosis Validated 0 _NA_ Q9H3D4 29212036 Delta Np63 alpha in article 2020/12/31 FerrDb team 53 Ferroptosis SLC7A11 HGNC:11059 Overexperession of SLC7A11 attenuated BAY-inhibited cell viability by ferroptosis. Human SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q9UPY5 29274359 _NA_ 2020/12/31 FerrDb team 54 Ferroptosis TP53 HGNC:11998 p53 stabilization suppresses ferroptosis. p53 suppresses metabolic stress-induced ferroptosis. Human TP53 :+: CDKN1A, CDKN1A :+: GSH, GSH :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 Found to promote ferroptosis by other studies. P04637 29346757 p53 in article 2020/12/31 FerrDb team 55 Ferroptosis CDKN1A HGNC:1784 Required to to suppress ferroptosis. Human CDKN1A :+: GSH, GSH :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P38936 29346757 Encoding p21 2020/12/31 FerrDb team 56 Ferroptosis MIR137 HGNC:31523 Suppresses ferroptosis both in vitro and in vivo. Human, mice MIR137 :-: SLC1A5, SLC1A5 :+: Glutaminolysis, Glutaminolysis :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 29348676 _NA_ 2020/12/31 FerrDb team 57 Ferroptosis SLC40A1 HGNC:10909 Overexpression of Fpn inhibited ferroptosis. Mice SLC40A1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9NP59 29436589 Fpn in article 2020/12/31 FerrDb team 58 Ferroptosis GPX4 HGNC:4556 Activation blocked ferroptosis. Mice GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P36969 29436589 _NA_ 2020/12/31 FerrDb team 59 Ferroptosis GPX4 HGNC:4556 GPX4-overexpressing cells were resistant to reactive oxygen species-induced cell death. Conversely, GPX4-knockdown cells were sensitive to reactive oxygen species-induced cell death. Human GPX4 :-: 8-OHdG, 8-OHdG :+: Ferroptosis Deduced 0 The authors did not determine wether the ROS-induced cell death is related to ferroptosis or not. P36969 29463878 _NA_ 2020/12/31 FerrDb team 60 Ferroptosis ENPP2 HGNC:3357 Overexpression modestly promotes migration and proliferation and significantly inhibits erastin-induced ferroptosis. Rat ENPP2 :-: Ferroptosis Validated 0 _NA_ Q13822 29551679 _NA_ 2020/12/31 FerrDb team 61 Ferroptosis VDAC2 HGNC:12672 Overexpression could partially protect cells from ferroptosis. Human VDAC2 :-: Ferroptosis Validated 0 _NA_ P45880 29569437 _NA_ 2020/12/31 FerrDb team 62 Ferroptosis FH HGNC:3700 FH inactivation (FH-/- ) proves synthetic lethal with inducers of ferroptosis. FH-/- sensitizes cells to multiple ferroptosis inducers. Human FH :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P07954 29917289 _NA_ 2020/12/31 FerrDb team 63 Ferroptosis CISD2 HGNC:24212 Overexpression conferred resistance to ferroptosis. Inhibition blocked resistance to ferroptotic cell death. Human CISD2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q8N5K1 29928961 _NA_ 2020/12/31 FerrDb team 64 Ferroptosis SLC40A1 HGNC:10909 A negative regulator of ferroptosis by reducing intracellular iron concentration. Knockdown accelerates erastin-induced ferroptosis. Human SLC40A1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9NP59 29949159 Ferroportin in article 2020/12/31 FerrDb team 65 Ferroptosis MIR9-1 HGNC:31641 Overexpression of miR‐9 suppressed GOT1, which subsequently reduced ferroptosis. Suppression of miR‐9 increased the sensitivity of melanoma cells to ferroptosis inducers. Human MIR9 :-: GOT1, GOT1 :+: alpha KG, alpha KG :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 30035324 miR-9 in article 2020/12/31 FerrDb team 66 Ferroptosis MIR9-2 HGNC:31642 Overexpression of miR‐9 suppressed GOT1, which subsequently reduced ferroptosis. Suppression of miR‐9 increased the sensitivity of melanoma cells to ferroptosis inducers. Human MIR9 :-: GOT1, GOT1 :+: alpha KG, alpha KG :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 30035324 miR-9 in article 2020/12/31 FerrDb team 67 Ferroptosis MIR9-3 HGNC:31646 Overexpression of miR‐9 suppressed GOT1, which subsequently reduced ferroptosis. Suppression of miR‐9 increased the sensitivity of melanoma cells to ferroptosis inducers. Human MIR9 :-: GOT1, GOT1 :+: alpha KG, alpha KG :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 30035324 miR-9 in article 2020/12/31 FerrDb team 68 Ferroptosis CBS HGNC:1550 Inhibition triggers ferroptosis in hepatocellular carcinoma. Human, mice CBS :-: Ferroptosis Validated 0 _NA_ P35520 30258181 _NA_ 2020/12/31 FerrDb team 69 Ferroptosis NFE2L2 HGNC:7782 Associated with resistance to ferroptosis. Inhibition of Nrf2 sensitized cells to ferroptosis. Human, mice NFE2L2 :+: FTH1, FTH1 :-: Ferroptosis, NFE2L2 :+: FPN, FPN :-: Ferroptosis, NFE2L2 :+: HO-1, HO-1 :-: Ferroptosis Validated 0 _NA_ Q16236 30339884 Nrf2 in article 2020/12/31 FerrDb team 70 Ferroptosis SQSTM1 HGNC:11280 Inhibition of the p62 gene significantly reduced cell viability and increased cellular lipid ROS levels in HN3R cells; this was reversed by treatment with ferrostatin-1, a ferroptosis inducer. Human SQSTM1 :+: NFE2L2, NFE2L2 :+: FTH1, FTH1 :-: Ferroptosis, NFE2L2 :+: FPN, FPN :-: Ferroptosis, NFE2L2 :+: HO-1, HO-1 :-: Ferroptosis Validated 0 Not test cell death or cell viability. Q13501 30339884 p62 in article. 2020/12/31 FerrDb team 71 Ferroptosis GPX4 HGNC:4556 Overexpression GPX4 resulted in decreased cell death after RSL3 treatment. Moreover, this effect was able to be reversed by overexpression of GPX4. Human GPX4 :-: Ferroptosis Validated 0 _NA_ P36969 30524291 _NA_ 2020/12/31 FerrDb team 72 Ferroptosis ISCU HGNC:29882 Over expression significantly attenuated DHA induced ferroptosis. Human ISCU :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q9H1K1 30557609 _NA_ 2020/12/31 FerrDb team 73 Ferroptosis FTH1 HGNC:3976 FTH reconstituted cells exhibited the reduced lipid peroxides content and restored the DHA-induced ferroptosis. Human FTH1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P02794 30557609 FTH in article 2020/12/31 FerrDb team 74 Ferroptosis ACSL3 HGNC:3570 Required for exogenous monounsaturated fatty acids to protect cells against ferroptosis. Negatively correlates with ferroptosis sensitivity. Human ACSL3 :-: Ferroptosis Validated 0 _NA_ O95573 30686757 _NA_ 2020/12/31 FerrDb team 75 Ferroptosis OTUB1 HGNC:23077 Inactivation promotes ferroptosis by down-regulating SLC7A11 levels. Overexpression is critical for tumor growth. Human, mice OTUB1 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q96FW1 30709928 _NA_ 2020/12/31 FerrDb team 76 Ferroptosis CD44 HGNC:1681 Knockdown sensitizes cells to ferroptosis. Human CD44 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P16070 30709928 _NA_ 2020/12/31 FerrDb team 77 Ferroptosis LINC00336 HGNC:33813 Overexpression inhibits ferroptosis. Knockdown promotes ferroptosis. Human (LINC00336/ELAVL1) :-: Ferroptosis Validated 0 _NA_ Q6ZUF6 30787392 _NA_ 2020/12/31 FerrDb team 78 Ferroptosis STAT3 HGNC:11364 Upregulated in ferroptosis resistant cells. Inhibition increases ferroptosis. Human STAT3 :-: Ferroptosis Validated 0 _NA_ P40763 30811078 _NA_ 2020/12/31 FerrDb team 79 Ferroptosis BRD4 HGNC:13575 Inhibition induces ferroptosis. Human BRD4 :-: Ferritinophagy, Ferritinophagy :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O60885 30988278 _NA_ 2020/12/31 FerrDb team 80 Ferroptosis PRDX6 HGNC:16753 A negative regulator of ferroptotic cell death. Human PRDX6 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P30041 31036877 _NA_ 2020/12/31 FerrDb team 81 Ferroptosis MIR17 HGNC:31547 Protects endothelial HUVEC cells from erastin-induced ferroptosis. Overexpression significantly reduced erastin-induced growth inhibition and ROS generation of HUVEC cells. Human MIR17 :-: A20, A20 :+: ACSL4, ACSL4 :+: Lipid ROS, A20 :-: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 31160087 miR-17-92 in article 2020/12/31 FerrDb team 82 Ferroptosis SCD HGNC:10571 Inhibition of SCD1 induces ferroptotic cell death. Expression of SCD1 protects cells from ferroptosis. Human, mice SCD :+: CoQ10, CoQ10 :-: Ferroptosis Validated 0 _NA_ O00767 31270077 SCD1 in article 2020/12/31 FerrDb team 83 Ferroptosis SESN2 HGNC:20746 Has cytoprotective effect against ferroptosis. In cells expressing Sesn2, erastin-induced cell death, ROS formation, and glutathione depletion were almost completely inhibited compared to that in control cells. Human, mice SESN2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P58004 31323261 Sesn2 in article 2020/12/31 FerrDb team 84 Ferroptosis NF2 HGNC:7773 Genetic inactivation of NF2 rendered cancer cells more sensitive to ferroptosis. Mediates cell density-dependent inhibition of ferroptosis. Human, mice NF2 :-: YAP, YAP :+: Ferroptosis Validated 0 _NA_ P35240 31341276 Also known as merlin 2020/12/31 FerrDb team 85 Ferroptosis ARNTL HGNC:701 Degration of the protein is critical for ferroptosis. Blocking ARNTL degradation diminished ferroptotic tumor cell death. Human, mice ARNTL :-: EGLN2, EGLN2 :-: HIF1A, HIF1A :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O00327 31355331 _NA_ 2020/12/31 FerrDb team 86 Ferroptosis HIF1A HGNC:4910 Destabilizing HIF1A facilitated ferroptotic tumor cell death. Human, mice HIF1A :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q16665 31355331 _NA_ 2020/12/31 FerrDb team 87 Ferroptosis JUN HGNC:6204 O-GlcNAcylated c-Jun represents an obstructive factor to ferroptosis. Human, mice JUN :+: GSH, GSH :-: Ferroptosis, JUN :+: PSAT1, PSAT1 :-: Ferroptosis, JUN :+: CBS, CBS :-: Ferroptosis Deduced 0 _NA_ P05412 31394193 c-Jun in article 2020/12/31 FerrDb team 88 Ferroptosis CA9 HGNC:1383 Inhibition induces ferroptosis. Human CA9 :-: Ferroptosis Validated 0 _NA_ Q16790 31442913 _NA_ 2020/12/31 FerrDb team 89 Ferroptosis HSPA5 HGNC:5238 Knockdown of GRP78 enhanced artesunate-induced ferroptosis of pancreatic cancer cells. Human, mice GRP78 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P11021 31456633 GRP78 in article 2020/12/31 FerrDb team 90 Ferroptosis TMBIM4 HGNC:24257 Protects against ferroptosis in HCC cells. Inhibition increased ferroptotic cel death. Human, mice S1R :-: Ferroptosis Validated 0 _NA_ Q9HC24 31507082 S1R in article 2020/12/31 FerrDb team 91 Ferroptosis HSPA5 HGNC:5238 Serves as a negative regulator of DHA-induced ferroptosis. Human, mice HSPA5 :+: GPX4, GPX4 :-: Ferroptosis Predicted 0 _NA_ P11021 31519193 _NA_ 2020/12/31 FerrDb team 92 Ferroptosis PLIN2 HGNC:248 An indispensable gene and protein in the suppression of ferroptosis caused by abnormal lipometabolism in gastric carcinoma. Human, mice PLIN2 :-: Ferroptosis Screened 0 _NA_ Q99541 31520166 Also known as ADRP 2020/12/31 FerrDb team 93 Ferroptosis MIR212 HGNC:31589 Overexpression of miR-212-5p attenuated ferroptosis while downregulation of miR-212-5p promoted ferroptotic cell death. Mice (miR-212-5p/Ptgs2) :-: Ferroptosis Validated 0 _NA_ _NA_ 31533781 miR-212-5p in article 2020/12/31 FerrDb team 94 Ferroptosis Fer1HCH _NA_ Reduced heavy chain levels caused severe mitochondrial defects and ferroptosis. Drosophila Fer1HCH :-: ROS, ROS :+: Ferroptosis Predicted 0 _NA_ H1UUD2 31568497 _NA_ 2020/12/31 FerrDb team 95 Ferroptosis AIFM2 HGNC:21411 A glutathione-independent ferroptosis suppressor. Pharmacological targeting of FSP1 strongly synergizes with GPX4 inhibitors to trigger ferroptosis. Human, mice FSP1 :+: CoQ10, CoQ10 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9BRQ8 31634899 FSP1 in article 2020/12/31 FerrDb team 96 Ferroptosis AIFM2 HGNC:21411 A potent ferroptosis-resistance factor. Positively correlates with ferroptosis resistance. Human, mice FSP1 :+: CoQ10, CoQ10 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9BRQ8 31634900 FSP1 in article 2020/12/31 FerrDb team 97 Ferroptosis LAMP2 HGNC:6501 Knockdown promoted ferroptosis. Human LAMP2 :+: Cysteine, Cysteine :+: GSH, GSH :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P13473 31672277 _NA_ 2020/12/31 FerrDb team 98 Ferroptosis ZFP36 HGNC:12862 ZFP36 plasmid impaired FBXW7 plasmid-induced HSC ferroptosis. Overexpression of Zfp36 impaired erastin- or sorafenib-induced ferroptosis. Human, mice ZFP36 :-: ATG16L1, ATG16L1 :+: Ferroptosis Validated 0 _NA_ P26651 31679460 _NA_ 2020/12/31 FerrDb team 99 Ferroptosis GPX4 HGNC:4556 Depletion or inhibition resulted in cell death by ferroptosis. Human, mice, rat GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P36969 31685805 _NA_ 2020/12/31 FerrDb team 100 Ferroptosis PROM2 HGNC:20685 Induced by ferroptotic stress and promotes resistance to ferroptotic cell death. Facilitates ferroptosis resistance in mammary epithelial and breast carcinoma cells. Human Prominin2 :+: Ferritin-containing MVB, Ferritin-containing MVB :-: Ferroptosis Validated 0 _NA_ Q8N271 31735663 Prominin2 in article 2020/12/31 FerrDb team 101 Ferroptosis CHMP5 HGNC:26942 Ferroptosis activators increase ESCRT-III subunits (e.g., CHMP5 and CHMP6). Knockdown of CHMP5 or CHMP6 sensitizes human cancer cells to ferroptosis. Human, mice CHMP5 :-: Ferroptosis Validated 0 _NA_ Q9NZZ3 31761326 _NA_ 2020/12/31 FerrDb team 102 Ferroptosis CHMP6 HGNC:25675 Ferroptosis activators increase ESCRT-III subunits (e.g., CHMP5 and CHMP6). Knockdown of CHMP5 or CHMP6 sensitizes human cancer cells to ferroptosis. Human, mice CHMP6 :-: Ferroptosis Validated 0 _NA_ Q96FZ7 31761326 _NA_ 2020/12/31 FerrDb team 103 Ferroptosis AKR1C1 HGNC:384 Inhibition completely resensitizes resistant melanoma cells to ferroptosis execution. Human AKR1C1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q04828 31780644 _NA_ 2020/12/31 FerrDb team 104 Ferroptosis AKR1C2 HGNC:385 Inhibition completely resensitizes resistant melanoma cells to ferroptosis execution. Human AKR1C2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P52895 31780644 _NA_ 2020/12/31 FerrDb team 105 Ferroptosis AKR1C3 HGNC:386 Inhibition completely resensitizes resistant melanoma cells to ferroptosis execution. Human AKR1C3 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P42330 31780644 _NA_ 2020/12/31 FerrDb team 106 Ferroptosis CBS HGNC:1550 Knockdown in erastin-resistant cells caused ferroptotic cell death, while overexpression conferred ferroptosis resistance. Human CBS :+: Cystathionine, Cystathionine :+: Cysteine, Cysteine :+: GSH, GSH :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P35520 31819185 _NA_ 2020/12/31 FerrDb team 107 Ferroptosis NFE2L2 HGNC:7782 Genetically repression of NRF2 enhanced ferroptosis susceptibility. Human NFE2L2 :+: CBS, CBS :+: Cystathionine, Cystathionine :+: Cysteine, Cysteine :+: GSH, GSH :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q16236 31819185 NRF2 in article 2020/12/31 FerrDb team 108 Ferroptosis CAV1 HGNC:1527 Cav-1 deficiency aggravated ferroptosis. Short hairpin RNA of Cav-1 promoted ferroptosis, which was ameliorated by Cav-1 overexpression. Human, mice CAV-1 :+: xCT, xCT :+: GPX4, GPX4 :-: Ferroptosis, CAV-1 :-: RNS, RNS :+: Ferroptosis Validated 0 _NA_ Q03135 31877357 Cav-1 in article 2020/12/31 FerrDb team 109 Ferroptosis GCH1 HGNC:4193 Gch1 overexpression and its downstream metabolites BH4/BH2 rescue from ferroptosis. Inhibition of GCH1 activity can sensitize resistant cancer cells to ferroptosis induction. Human GCH1 :+: Phospholipid, Phospholipid :-: Ferroptosis, GCH1 :+: CoQ10, CoQ10 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P30793 31989025 _NA_ 2021/5/15 FerrDb team 110 Ferroptosis SIRT3 HGNC:14931 These data indicate that inactivation of Sirt3 significantly sensitizes cells to p53-dependent ferroptosis upon ROS-induced stress. Human SIRT3 :-: Ferroptosis Validated 0 _NA_ Q9NTG7 33377976 _NA_ 2021/6/30 FerrDb team 111 Ferroptosis DAZAP1 HGNC:2683 Furthermore, DAZAP1 significantly reduced cellular sensitivity to sorafenib (SF), which had been proven to be an inducer of ferroptosis by targeting the system Xc−. _NA_ (DAZAP1/SLC7A11) :-: Ferroptosis Validated 0 Corrigendum Q96EP5 33358859 _NA_ 2021/7/2 FerrDb team 112 Ferroptosis PIR HGNC:30048 Consequently, in cell cultures and xenograft mouse models, blocking PIR signaling enhances ferroptosis-mediated tumor growth suppression. Human, mice PIR :-: oxidative DNA damage, oxidative DNA damage :+: HMGB1, HMGB1 :+: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ O00625 33373853 _NA_ 2021/7/2 FerrDb team 113 Ferroptosis GCLC HGNC:4311 Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis Human GCLC :+: gamma-glutamyl-peptides, gamma-glutamyl-peptides :-: Glu, Glu :+: Ferroptosis Validated 0 _NA_ P48506 33357455 _NA_ 2021/7/9 FerrDb team 114 Ferroptosis FTL HGNC:3999 Ferritin upregulation prevents ferroptosis by mediating P53 and SLC7A11 expression. Rat FTL :-: p53, FTL :-: SLC7A11, p53 :+: Ferroptosis, SLC7A11 :+: Ferroptosis Validated 0 _NA_ P02792 33333054 Ferritin in article 2021/7/12 FerrDb team 115 Ferroptosis HCAR1 HGNC:4532 These observations support our hypothesis that HCAR1 and MCT1 are involved in the lactate-dependent ferroptosis resistance in tumor cells. Blocking the HCAR1/MCT1-Mediated Lactate Import Exacerbates Ferroptosis Human, mice (HCAR1/MCT1) :-: (AMP/ATP), (AMP/ATP) :+: AMPK, AMPK :-: SREBP1, SREBP1 :+: SCD1, SCD1 :-: Ferroptosis, (HCAR1/MCT1) :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ Q9BXC0 33296645 _NA_ 2021/7/12 FerrDb team 116 Ferroptosis SLC16A1 HGNC:10922 These observations support our hypothesis that HCAR1 and MCT1 are involved in the lactate-dependent ferroptosis resistance in tumor cells. Blocking the HCAR1/MCT1-Mediated Lactate Import Exacerbates Ferroptosis Human, mice (HCAR1/MCT1) :-: (AMP/ATP), (AMP/ATP) :+: AMPK, AMPK :-: SREBP1, SREBP1 :+: SCD1, SCD1 :-: Ferroptosis, (HCAR1/MCT1) :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ P53985 33296645 MCT1 in article 2021/7/16 FerrDb team 117 Ferroptosis RRM2 HGNC:10452 RRM2 exerts an anti-ferroptotic role in liver cancer cells by sustaining GSH synthesis. Human RRM2 :+: GSS, GSS :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ P31350 33372599 _NA_ 2021/7/19 FerrDb team 118 Ferroptosis SCD HGNC:10571 Genetic and Pharmacological Inhibition of SCD1 Prevents the Growth of STK11/KEAP1 Co-mutant Cells and Sensitizes Those Cells to Ferroptosis Induction. Human SCD :-: Ferroptosis Validated 0 _NA_ O00767 33264619 SCD1 in article 2021/7/26 FerrDb team 119 Ferroptosis NR4A1 HGNC:7980 Pharmacological inhibition of NR4A1 promotes ferroptosis in pancreatic cancer cells Human NR4A1 :+: SCD1, SCD1 :-: Ferroptosis Deduced 0 _NA_ P22736 33271455 _NA_ 2021/8/2 FerrDb team 120 Ferroptosis PIK3CA HGNC:8975 Notably, we found that cancer cells carrying PIK3CA activating mutation or PTEN deletion appeared to be more resistant to RSL3. These mutations lead to the activation of the oncogenic PI3K-AKT signaling pathway. Therefore, sustained activation of the PI3K-AKT-mTOR pathway protects cancer cells from ferroptotic cell death. Human PIK3CA :+: PI3K-AKT pathway, PI3K-AKT pathway :-: Ferroptosis Deduced 0 _NA_ P42336 33229547 _NA_ 2021/8/2 FerrDb team 121 Ferroptosis RPTOR HGNC:30287 mTORC1, Instead of mTORC2, Suppresses Ferroptosis. short-hairpin RNA (shRNA)-mediated silencing of RAPTOR (a component of mTORC1) but not that of RICTOR (a component of mTORC2) sensitized MDA-MB-453 and BT474 cells to RSL3. Human RAPTOR :+: mTORC1, mTORC1 :+: SREBP1, SREBP1 :+: SCD1, SCD1 :-: Ferroptosis Deduced 0 _NA_ Q8N122 33229547 RAPTOR in article 2021/8/2 FerrDb team 122 Ferroptosis SREBF1 HGNC:11289 SREBP1 Protects Cells from Ferroptosis through SCD1 Activity. Human SREBP1 :+: SCD1, SCD1 :-: Ferroptosis Validated 0 _NA_ P36956 33229547 SREBP1 in article 2021/8/2 FerrDb team 123 Ferroptosis SREBF2 HGNC:11290 The lipogenesis regulator SREBP2 directly induces transcription of the iron carrier Transferrin (TF), reducing intracellular iron pools, reactive oxygen species, and lipid peroxidation, thereby conferring resistance to inducers of ferroptosis. Human SREBP2 :+: TF, TF :-: ROS, ROS :+: Lipid peroxidation, Lipid peroxidation :+: Ferroptosis Validated 0 _NA_ Q12772 33203734 SREBP2 in article 2021/8/6 FerrDb team 124 Ferroptosis FZD7 HGNC:4045 Conversely, FZD7 overexpression induced increased GPX4 mRNA and protein expression levels. FZD7 Marks a Cell Population Susceptible to GPX4 Inhibitors. Human, mice FZD7 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ O75084 33172933 _NA_ 2021/8/9 FerrDb team 125 Ferroptosis NFE2L2 HGNC:7782 In FRDA fibroblasts, both treatments promoted the nuclear translocation of Nrf2 (Fig. 5A) and the inhibition of redox imbalance and ferroptosis. Mice Nrf2 :-: ROS, ROS :+: Ferroptosis Validated 0 _NA_ Q16236 33197769 Nrf2 in article 2021/8/18 FerrDb team 126 Ferroptosis NFE2L2 HGNC:7782 Up-regulating Nrf2 alleviated the diabetes related ferroptosis in kidneys. Mice Nrf2 :-: Ferroptosis Validated 0 _NA_ Q16236 33152439 NRF2 in article 2021/8/21 FerrDb team 127 Ferroptosis P4HB HGNC:8548 Knockdown of these target genes sensitized cells to known ferroptosis inducers, while PACMA31, a previously reported inhibitor of P4HB, directly induced ferroptosis and was highly synergistic with erastin. Human P4HB :-: ER stress, ER stress :+: Ferroptosis Deduced 0 _NA_ P07237 33124817 _NA_ 2021/8/21 FerrDb team 128 Ferroptosis NT5DC2 HGNC:25717 Knockdown of these target genes sensitized cells to known ferroptosis inducers, while PACMA31, a previously reported inhibitor of P4HB, directly induced ferroptosis and was highly synergistic with erastin. _NA_ NT5DC2 :-: Ferroptosis Deduced 0 _NA_ Q9H857 33124817 _NA_ 2021/8/21 FerrDb team 129 Ferroptosis BCAT2 HGNC:977 Here, by using a high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells to search for metabolic proteins inhibiting ferroptosis, we identified a branched-chain amino acid aminotransferase 2 (BCAT2) as a novel suppressor of ferroptosis. Human BCAT2 :-: Ferroptosis Validated 0 _NA_ O15382 33097833 _NA_ 2021/8/23 FerrDb team 130 Ferroptosis HSF1 HGNC:5224 Altogether, HSF1 may function as a key defender against PA-induced ferroptosis in cardiomyocytes by maintaining cellular iron homeostasis and GPX4 expression. Human, mice HSF1 :-: Ferroptosis Validated 0 _NA_ Q00613 33098823 _NA_ 2021/8/27 FerrDb team 131 Ferroptosis PLA2G6 HGNC:9039 PLA2G6 Deficiency Sensitizes Trophoblasts to Ferroptosis. Human, mice PLA2G6 :-: Ferroptosis Validated 0 _NA_ O60733 33087576 _NA_ 2021/8/27 FerrDb team 132 Ferroptosis MIR424 HGNC:31881 In the present study, we show that miR-424-5p negatively regulates ferroptosis by directly targeting ACSL4 in ovarian cancer cells. Human miR-424-5p :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ _NA_ 33038905 miR-424-5p in article 2021/8/30 FerrDb team 133 Ferroptosis PARK7 HGNC:16369 Therefore, our results further implied that the C terminus of DJ-1 mediates the suppression of ferroptosis, and when the C-terminal structure is destroyed, DJ-1 inhibition of ferroptosis is abolished. Human, mice PARK7 :-: Ferroptosis Validated 0 _NA_ " Q99497" 33024240 DJ-1 in article 2021/9/1 FerrDb team 134 Ferroptosis FXN HGNC:3951 Most importantly, frataxin deficiency enhanced ferroptosis driven by ethanol via evaluating the levels of lactate dehydrogenase, cell morphological changes, mitochondrial labile iron pool, and lipid peroxidation. Conversely, restoring frataxin alleviated the sensitivity to ferroptosis. In addition, frataxin overexpression mitigated the sensitivity of ethanol-induced ferroptosis in HepG2CYP2E1+/+. Human FXN :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q16595 33017621 frataxin in article 2021/9/3 FerrDb team 135 Ferroptosis SUV39H1 HGNC:11479 Mechanistically, we discovered that siRNA knockdown or pharmacological inhibition of SUV39H1 induced iron accumulation and lipid peroxidation, leading to ferroptosis that disrupted ccRCC cell growth in vitro and in vivo. Human SUV39H1 :-: DPP4, DPP4 :+: Ferroptosis Validated 0 _NA_ O43463 33643820 _NA_ 2021/9/3 FerrDb team 136 Ferroptosis ATF2 HGNC:784 All these results suggested that ATF2 inhibited BETi-induced ferroptosis by increasing NRF2 expression. Human ATF2 :+: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ P15336 33008584 _NA_ 2021/9/6 FerrDb team 137 Ferroptosis CDKN1A HGNC:1784 While this study was performed in cancer cell lines, our results support the potential of p21 to aid in maintenance of healthy tissues by blocking the damage incurred due to ferroptosis. Human (p21/CDK2) :-: Ferroptosis Predicted 0 _NA_ P38936 32979260 p21 in article 2021/9/6 FerrDb team 138 Ferroptosis FTH1 HGNC:3976 FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson's Disease. Rat FTH1 :-: Ferroptosis Validated 0 _NA_ P02794 32959272 _NA_ 2021/9/8 FerrDb team 139 Ferroptosis NFE2L2 HGNC:7782 Nrf2 Upregulation Inhibits Ferroptosis and Plays a Protective Role in IIR-ALI. Mice Nrf2 :+: SLC7A11, SLC7A11 :+: Cystine, Cystine :+: GSH, GSH :+: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q16236 33014271 NRF2 in article 2021/9/10 FerrDb team 140 Ferroptosis STAT3 HGNC:11364 STAT3 Overexpression Upregulates SLC7A11 and Ameliorates OGD/R-Induced MLE12 Ferroptosis. Mice STAT3 :+: SLC7A11, SLC7A11 :+: Cystine, Cystine :+: GSH, GSH :+: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P40763 33014271 _NA_ 2021/9/10 FerrDb team 141 Ferroptosis ACOT1 HGNC:33128 Overexpression of Acot1 in cell lines showed noteworthy protection to ferroptosis, while the knock-down of Acot1 sensitized cardiomyocytes to ferroptosis by DIC. Mice ACOT1 :-: Ferroptosis Validated 0 _NA_ Q86TX2 32934217 _NA_ 2021/9/15 FerrDb team 142 Ferroptosis NFE2L2 HGNC:7782 Furthermore, Nfe2l2 (Nrf2) knockdown sensitized cells to ferroptotic cell death. Rat Nrf2 :+: SLC7A11, SLC7A11 :+: GSH, GSH :-: Ferroptosis, Nrf2 :+: GCL, GCL :+: GSH, GSH :-: Ferroptosis, Nrf2 :+: FTH1, FTH1 :-: Ferroptosis Validated 0 _NA_ Q16236 32937103 Nrf2 in article 2021/9/15 FerrDb team 143 Ferroptosis ALDH3A2 HGNC:403 Thus, our results show that loss of Aldh3a2 induces ferroptotic cell death in leukemic cells and is synthetically lethal with GPX4 inhibtion. Mice ALDH3A2 :-: Ferroptosis Validated 0 _NA_ P51648 32458004 Aldh3a2 in article 2021/9/17 FerrDb team 144 Ferroptosis NFE2L2 HGNC:7782 Nrf2 acivation inhibited seawater-induced ferroptosis in MLE-12 cells. Nrf2 deficiency aggravated lung injury and ferroptosis in mice induced by seawater drowning. Mice Nrf2 :-: Ferroptosis Validated 0 _NA_ Q16236 32907551 Nrf2 in article 2021/9/17 FerrDb team 145 Ferroptosis STK11 HGNC:11389 Loss of function of the tumor suppressor LKB1 enhances sensitivity to ferroptosis in human non-small cell lung cancer cells. Human LKB1 :+: AMPK, AMPK :-: ACC1, ACC1 :+: FAS, FAS :+: Ferroptosis Validated 0 _NA_ Q15831 32883948 LKB1 in article 2021/9/17 FerrDb team 146 Ferroptosis FNDC5 HGNC:20240 Serum irisin levels are decreased and negatively correlated with disease severity in patients with sepsis, and irisin treatment suppresses ferroptosis and restores mitochondrial function in experimental sepsis. Human, mice Irisin :-: Ferroptosis Deduced 0 Irisin is a cleavage protein of fibronectin type III domain 5 (FNDC5). Q8NAU1 32997405 Irisin in article 2021/9/26 FerrDb team 147 Ferroptosis CircIL4R _NA_ CircIL4R knockdown impeded oncogenesis and expedited ferroptosis of HCC cells. Human CircIL4R :-: miR-541-3p, miR-541-3p :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 32808701 CircIL4R in article 2021/9/27 FerrDb team 148 Ferroptosis CDH1 HGNC:1748 CDH1 silencing or ZEB1 overexpression increased the susceptibility to ferroptosis, whereas CDH overexpression or ZEB1 silencing decreased the susceptibility, in vitro and in vivo. Human, mice CDH1 :-: Ferroptosis Validated 0 _NA_ " P12830" 32896720 _NA_ 2021/9/27 FerrDb team 149 Ferroptosis NFE2L2 HGNC:7782 NRF2 negatively regulates FOCAD expression. FOCAD enhances the sensitivity of NSCLC cells to the ferroptosis induced by cysteine deprivation, but not GPX4 inhibition. Human NFE2L2 :-: FOCAD, FOCAD :+: FAK, FAK :+: Ferroptosis Validated 0 _NA_ Q16236 32898818 NRF2 in article 2021/10/8 FerrDb team 150 Ferroptosis MIR214 HGNC:31591 PVT1 silencing or miR-214 overexpression significantly reduced infarct size and suppressed ferroptosis in vivo. Human, mice MIR214 :-: PVT1, PVT1 :+: Ferroptosis Validated 0 _NA_ _NA_ 32827544 miR-214 in article 2021/10/13 FerrDb team 151 Ferroptosis NEDD4L HGNC:7728 Here, we screened 571 UPS-related E1, E2, and E3 genes in a human pancreatic cancer cell line (PANC1) and identified the upregulation of NEDD4-like E3 ubiquitin protein ligase (NEDD4L) as a novel ferroptosis suppressor. Human NEDD4L :-: LTF, LTF :+: Ferroptosis Validated 0 _NA_ Q96PU5 32811647 _NA_ 2021/10/14 FerrDb team 152 Ferroptosis SQSTM1 HGNC:11280 Taken together, our results indicated that high p62 expression protects SH-SY5Y cells against 6-OHDA-induced ferroptosis. Human (SQSTM1/Keap1) :+: Nrf2, Nrf2 :-: Ferroptosis, (SQSTM1/Keap1) :+: HO-1, HO-1 :-: Ferroptosis Validated 0 _NA_ " Q13501" 32770451 _NA_ 2021/10/15 FerrDb team 153 Ferroptosis TF HGNC:11740 Trf-LKO mice display iron-deficiency anemia, iron overload in tissues, and susceptibility to liver damage via ferroptosis. Human, mice TF :-: Ferroptosis Validated 0 Recognized as a driver in other studies. P02787 32374849 transferrin/Trf in article 2021/10/17 FerrDb team 154 Ferroptosis FTMT HGNC:17345 FTMT and ferritin heavy chain (FTH) cooperated to protect macrophages from RSL-3-induced ferroptosis under hypoxia as this form of cell death is linked to iron metabolism. In hypoxic macrophages either FTMT or FTH was sufficient to protect from ferroptosis Human FTMT :-: Ferroptosis Validated 0 _NA_ Q8N4E7 32810738 _NA_ 2021/10/28 FerrDb team 155 Ferroptosis BRD2 HGNC:1103 Inhibition of BET and the proteasome triggers ferroptosis cell death. Human BRD2 :-: Ferroptosis Deduced 0 _NA_ P25440 32937365 _NA_ 2021/10/28 FerrDb team 156 Ferroptosis BRD3 HGNC:1104 Inhibition of BET and the proteasome triggers ferroptosis cell death. Human BRD3 :-: Ferroptosis Deduced 0 _NA_ Q15059 (BRD3_HUMAN 32937365 _NA_ 2021/10/28 FerrDb team 157 Ferroptosis BRD4 HGNC:13575 Inhibition of BET and the proteasome triggers ferroptosis cell death. Human BRD4 :-: Ferroptosis Deduced 0 _NA_ O60885 32937365 _NA_ 2021/10/28 FerrDb team 158 Ferroptosis BRDT HGNC:1105 Inhibition of BET and the proteasome triggers ferroptosis cell death. Human BRDT :-: Ferroptosis Deduced 0 _NA_ Q58F21 32937365 _NA_ 2021/10/28 FerrDb team 159 Ferroptosis SCD HGNC:10571 Collectively, this study demonstrated that SCD1 could promote tumor growth of gastric cancer cells and protect them from ferroptotic cell death. Human, mice SCD :+: SLC7A11, SLC7A11 :-: Ferroptosis, SCD :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ O00767 32726752 SCD1 in article 2021/11/4 FerrDb team 160 Ferroptosis SLC7A11 HGNC:11059 Furthermore, we found that SLC7A11 knockdown increased vulnerability of mature MO3.13 cells to ferroptosis. Human SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q9UPY5 32608563 _NA_ 2021/11/5 FerrDb team 161 Ferroptosis DECR1 HGNC:2753 Collectively, these results suggest that DECR1 expression protect cells from oxidative stress and that DECR1 knockdown-induced cell death is primarily mediated by induction of ferroptosis. Human DECR1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q16698 32686647 _NA_ 2021/11/11 FerrDb team 162 Ferroptosis NFE2L2 HGNC:7782 Nrf2 inhibition promotes erastin‑induced ferroptosis. Human NFE2L2 :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q16236 32642794 Nrf2 in article 2021/11/11 FerrDb team 163 Ferroptosis GPX4 HGNC:4556 Overexpression of GPX4 significantly reduced lipid peroxidation and cell death in the experimental SAH models both in vivo and in vitro. Rat GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P36969 32634425 _NA_ 2021/11/16 FerrDb team 164 Ferroptosis SLC7A11 HGNC:11059 Knockout of SLC7A11 facilitates the process of ferroptosis in colorectal CSCs. Human SLC7A11 :+: Cystine, Cystine :-: Ferroptosis, SLC7A11 :+: Glutathione, Glutathione :-: Ferroptosis, SLC7A11 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9UPY5 32621966 _NA_ 2021/11/17 FerrDb team 165 Ferroptosis NFE2L2 HGNC:7782 Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1. Mice NFE2L2 :+: SLC7A11, SLC7A11 :-: Ferroptosis, NFE2L2 :+: HO-1, HO-1 :-: Ferroptosis Validated 0 _NA_ Q16236 32601262 Nrf2 in article. 2021/11/17 FerrDb team 166 Ferroptosis GLRX5 HGNC:20134 Inhibition of GLRX5 promotes ferroptotic cell death of HNC cells. Human, mice GLRX5 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q86SX6 32685019 _NA_ 2021/11/20 FerrDb team 167 Ferroptosis GPX4 HGNC:4556 Glutathione peroxidase (GPX4) is critical for the reduction of toxic lipid hydroperoxides to their corresponding non-deleterious alcohols at the expense of reduced glutathione and thereby prevents cellular damage and induction of ferroptosis. Human GPX4 :-: Ferroptosis Validated 0 _NA_ P36969 32577235 _NA_ 2021/11/21 FerrDb team 168 Ferroptosis NCOA3 HGNC:7670 NCOA3 as a coactivator synergized with NR5A2 to prevent BETi induced ferroptosis. Human NCOA3 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q9Y6Q9 32536370 _NA_ 2021/11/26 FerrDb team 169 Ferroptosis NR5A2 HGNC:7984 NCOA3 as a coactivator synergized with NR5A2 to prevent BETi induced ferroptosis. Human NR5A2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ O00482 32536370 _NA_ 2021/11/26 FerrDb team 170 Ferroptosis GPX4 HGNC:4556 GPX4 depletion induces autophagy-dependent ferroptosis. Human GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P36969 32457486 _NA_ 2021/11/30 FerrDb team 171 Ferroptosis MTOR HGNC:3942 MTOR inhibitor induces GPX4 protein degradation. Interplay between MTOR and GPX4 signaling modulates autophagy dependent ferroptotic cancer cell death. Human MTOR :+: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P42345 32457486 _NA_ 2021/12/1 FerrDb team 172 Ferroptosis PANX2 HGNC:8600 PANX2 Silencing Promotes Ferroptosis in PCa Cells. Human PANX2 :-: Fe2, Fe2 :+: Ferroptosis, PANX2 :-: MDA, MDA :+: Ferroptosis Validated 0 _NA_ Q96RD6 32547072 _NA_ 2021/12/1 FerrDb team 173 Ferroptosis RHEBP1 HGNC:10010 Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis. Human, mice RHEBP1 :-: Ferroptosis Validated 0 Many studies revealed that apoptosis, necroptosis as well as ferroptosis all contribute to cisplatin-induced tubular cell death and AKI. _NA_ 32404875 Rheb1 in article. 2021/12/2 FerrDb team 174 Ferroptosis TFAP2A HGNC:11742 TFAP2A Inhibition Promotes Ferroptosis. Human TFAP2A :-: Fe2+, Fe2+ :+: Ferroptosis Validated 0 _NA_ P05549 32432738 _NA_ 2021/12/9 FerrDb team 175 Ferroptosis CP HGNC:2295 Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells. Human CP :-: Fe2+, Fe2+ :+: Ferroptosis, CP :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P00450 32283255 _NA_ 2021/12/9 FerrDb team 176 Ferroptosis SLC7A11 HGNC:11059 Collectively, these data suggest that SLC7A11 inhibits the ferroptosis induced by IMCA. Human SLC7A11 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q9UPY5 32322334 _NA_ 2021/12/15 FerrDb team 177 Ferroptosis ARF6 HGNC:659 Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells. Human ARF6 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ P62330 32368394 _NA_ 2021/12/16 FerrDb team 178 Ferroptosis GDF15 HGNC:30142 GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression. Human GDF15 :+: SLC7A11, SLC7A11 :-: Ferroptosis, GDF15 :+: System Xc-, System Xc- :-: Ferroptosis Validated 0 _NA_ Q99988 32209255 _NA_ 2021/12/17 FerrDb team 179 Ferroptosis ABHD12 HGNC:15868 Blockade of the lysophosphatidylserine lipase ABHD12 potentiates ferroptosis in cancer cells. Human ABHD12 :-: Ferroptosis Validated 0 _NA_ Q8N2K0 32195565 _NA_ 2021/12/17 FerrDb team 180 Ferroptosis PPP1R13L HGNC:18838 iASPP overexpression inhibits ferroptosis, and iASPP knockdown promotes ferroptosis in vivo. Mice PPP1R13L :+: Nrf2, Nrf2 :-: Ferroptosis Validated 0 _NA_ Q8WUF5 32203170 iASPP in article. 2021/12/19 FerrDb team 181 Ferroptosis TFAM HGNC:11741 Zalcitabine-induced TFAM degradation promotes ferroptosis. Human TFAM :-: Ferroptosis Validated 0 _NA_ Q00059 32186434 _NA_ 2021/12/19 FerrDb team 182 Ferroptosis KDM3B HGNC:1337 Overexpressed KDM3B prevents cells from Erastin-induced ferroptosis. Human KDM3B :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q7LBC6 32107878 _NA_ 2021/12/20 FerrDb team 183 Ferroptosis RNF113A HGNC:12974 RNF113A deficiency indeed potentiated the production of lipid ROS, which accumulate in cells undergoing ferroptosis, upon Cisplatin stimulation, as evidenced by the quantification of BODIPY-C11 staining. Human RNF113A :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O15541 32152280 _NA_ 2021/12/20 FerrDb team 184 Ferroptosis PARK7 HGNC:16369 DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase. Human PARK7 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, PARK7 :+: GSH, GSH :-: Ferroptosis, PARK7 :+: AHCY, AHCY :-: Ferroptosis Validated 0 _NA_ Q99497 32144268 DJ-1 in article. 2021/12/21 FerrDb team 185 Ferroptosis AHCY HGNC:343 Suppression of SAHH expression by RNA interference also promoted erastin-induced accumulation of lipid ROS (Fig. 5i, j), which phenocopied the DJ-1 KD effect. Human AHCY :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ P23526 32144268 SAHH in article. 2021/12/21 FerrDb team 186 Ferroptosis FXN HGNC:3951 Suppression of FXN enhanced erastin-induced ferroptosis. Human FXN :-: Lipid ROS, Lipid ROS :+: Ferroptosis, FXN :-: labile iron, labile iron :+: Ferroptosis Validated 0 _NA_ Q16595 32169822 _NA_ 2021/12/22 FerrDb team 187 Ferroptosis circ-TTBK2 HGNC:19141 Knockdown of circ-TTBK2 suppressed cell proliferation, invasion, and promoted ferroptosis in glioma cells. Human circ-TTBK2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, circ-TTBK2 :+: ITGB8, ITBG8 :-: Ferroptosis Validated 0 _NA_ Q6IQ55 32196629 circ-TTBK2 2021/12/22 FerrDb team 188 Ferroptosis MIR522 HGNC:32127 CAFs secreted exo-miR-522 suppresses ferroptosis of GC cells. Human MIR522 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 32106859 miR-522 in article. 2021/12/22 FerrDb team 189 Ferroptosis IDH2 HGNC:5383 Knockdown of IDH2 promotes ferroptosis in cells treated with erastin. Human, mice IDH2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P48735 32089268 _NA_ 2021/12/30 FerrDb team 190 Ferroptosis PPARA HGNC:9232 In the p53 KO derivatives of both HT-1080 and SK-Hep1 cells, increased PPARα activity suppressed ferroptosis (Fig. 6C, D), while decreased PPARα activity increased their sensitivity to ferroptosis (Fig. 6E,F). Human PPARA :-: Ferroptosis Validated 0 _NA_ Q07869 32079652 PPARα in article. 2021/12/30 FerrDb team 191 Ferroptosis NOS2 HGNC:7873 Knockdown (KD) of iNOS caused increased sensitivity of M1 RAW 264.7 macrophages and EOC 20 cells to RSL3 induced death that was effectively suppressed by Fer-1. Mice NOS2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P35228 32080625 iNOS in article. 2021/12/30 FerrDb team 192 Ferroptosis SIAH2 HGNC:10858 Additionally SIAH2-deficient cells are also characterized by reduced expression levels of glutathione peroxidase 4 (GPX4), rendering the knock-out cells more sensitive to ferroptosis. Human SIAH2 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ O43255 32042051 _NA_ 2021/12/30 FerrDb team 193 Ferroptosis RELA HGNC:9955 Deficiency of IEC NF-κBp65 led to upregulated ER stress-mediated ferroptosis in colitis Mice RELA :-: ER stress, ER stress :+: Ferroptosis Validated 0 _NA_ Q04206 32015337 NF-κBp65 in article. 2021/12/31 FerrDb team 194 Ferroptosis PRKAA2 HGNC:9377 AMPK inactivation sensitizes cancer cells to ferroptotic cell death. Human PRKAA2 :+: phosphorylation of ACC, phosphorylation of ACC :-: Ferroptosis, PRKAA2 :-: PUFA-containing lipid biosynthesis, PUFA-containing lipid biosynthesis :+: Ferroptosis Validated 0 _NA_ P54646 32029897 AMPK in article. 2021/12/30 FerrDb team 195 Ferroptosis VDR HGNC:12679 VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis. Mice VDR :-: Lipid ROS, Lipid ROS :+: Ferroptosis, VDR :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P11473 31996668 _NA_ 2021/12/30 FerrDb team 196 Ferroptosis NEDD4 HGNC:7727 Nedd4 negatively regulates erastin-induced ferroptosis. Human NEDD4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, NEDD4 :-: iron accumulation, iron accumulation :+: Ferroptosis, NEDD4 :+: GSH, GSH :-: Ferroptosis, NEDD4 :-: GSSG, GSSG :+: Ferroptosis Validated 0 _NA_ P46934 31974380 Nedd4 in article. 2021/12/30 FerrDb team 197 Ferroptosis FXN HGNC:3951 FXN deficiency impairs thermogenesis and adipogenesis and increases susceptibility to ferroptosis in cultured adipocytes. Mice FXN :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q16595 31974344 _NA_ 2021/12/30 FerrDb team 198 Ferroptosis AIFM2 HGNC:21411 AIFM2 blocks ferroptosis independent of ubiquinol metabolism. Human AIFM2 :+: ESCRT-III, ESCRT-III :-: Ferroptosis Validated 0 _NA_ Q9BRQ8 31964528 _NA_ 2021/12/30 FerrDb team 199 Ferroptosis PRDX1 HGNC:9352 Consistent with our previous observation, loss of PRDX1 was sufficient to induce a significant increase in lipid peroxidation (Fig. 3B). Human PRDX1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q06830 31901729 _NA_ 2022/1/7 FerrDb team 200 Ferroptosis AR HGNC:644 Furthermore, overexpression of AR prevented ferroptosis in the presence of GPX4. Human AR :+: GPX4, GPX4 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P10275 31896509 _NA_ 2022/1/7 FerrDb team 201 Ferroptosis CBS HGNC:1550 CBS RNAi-induced cell death was also blocked by Fer-1 and Lip-1, indicating that inhibition of CBS in the context of system Xc- blockage caused ferroptosis. Human CBS :+: GSH, GSH :-: Ferroptosis, CBS :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P35520 31819185 _NA_ 2022/1/7 FerrDb team 202 Ferroptosis NFE2L2 HGNC:7782 Genetically repression of NRF2 enhanced ferroptosis susceptibility. Human NFE2L2 :+: CBS, CBS :-: Ferroptosis, NFE2L2 :+: GSH, GSH :-: Ferroptosis, NFE2L2 :-: MDA, MDA :+: Ferroptosis Validated 0 _NA_ Q16236 31819185 NRF2 in article. 2022/1/7 FerrDb team 203 Ferroptosis CHMP5 HGNC:26942 Compared to the control shRNA group, suppressing CHMP5 or CHMP6 expression by shRNA increased erastin- or RSL3-induced cell death (Fig. 3B), indicating that ESCRT-III plays a pro-survival role in ferroptosis. Human CHMP5 :-: HMGB1, HMGB1 :+: Ferroptosis Validated 0 _NA_ Q9NZZ3 31761326 _NA_ 2022/1/7 FerrDb team 204 Ferroptosis CHMP6 HGNC:25675 Compared to the control shRNA group, suppressing CHMP5 or CHMP6 expression by shRNA increased erastin- or RSL3-induced cell death (Fig. 3B), indicating that ESCRT-III plays a pro-survival role in ferroptosis. Human CHMP6 :-: HMGB1, HMGB1 :+: Ferroptosis Validated 0 _NA_ Q96FZ7 31761326 _NA_ 2022/1/7 FerrDb team 205 Ferroptosis HMOX1 HGNC:5013 WT MEFs became more sensitive to ferroptosis by knockdown of Hmox1 than cells with control knockdown (Figs. S5D, S6D, and S7D). Mice HMOX1 :-: Ferroptosis Validated 0 _NA_ P09601 31740582 _NA_ 2022/1/7 FerrDb team 206 Ferroptosis ZFP36 HGNC:12862 RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells. Human, mice ZFP36 :-: iron levels, iron levels :+: Ferroptosis, ZFP36 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, ZFP36 :+: GSH, GSH :-: Ferroptosis, ZFP36 :-: MDA, MDA :+: Ferroptosis Validated 0 _NA_ P26651 31679460 _NA_ 2022/1/7 FerrDb team 207 Ferroptosis LAMP2 HGNC:6501 Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells. Human LAMP2 :+: GSH, GSH :-: Ferroptosis, LAMP2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P13473 31672277 _NA_ 2022/1/10 FerrDb team 208 Ferroptosis MTF1 HGNC:7428 Importantly, MTF1 silencing also abolished the ferroptosis protection phenotypes of ATM silencing (Fig. 5c). Human MTF1 :-: ATM, ATM :-: FPN1, FPN1 :-: Fe, ATM :-: FTH1, FTH1 :-: Fe, ATM :-: FTL, FTL :-: Fe, Fe :+: Ferroptosis Validated 0 _NA_ Q14872 31320750 _NA_ 2022/1/10 FerrDb team 209 Ferroptosis COPZ1 HGNC:2243 Knockdown of COPZ1 causes ferroptosis in GBM cells. Human COPZ1 :-: NCOA4, NCOA4 :-: ferritin, ferritin :-: ferrous iron, ferrous iron :+: Ferroptosis Validated 0 _NA_ P61923 33420375 _NA_ 2022/1/19 FerrDb team 210 Ferroptosis NUPR1 HGNC:29990 NUPR1 is a critical repressor of ferroptosis. Human NUPR1 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, NUPR1 :+: LCN2, LCN2 :-: Fe2, Fe2 :+: Ferroptosis, NUPR1 :+: LCN2, LCN2 :-: MDA, MDA :+: Ferroptosis Validated 0 _NA_ O60356 33510144 _NA_ 2022/1/26 FerrDb team 211 Ferroptosis USP35 HGNC:20061 USP35 knockdown promotes ferroptosis in lung cancer cells. Human USP35 :+: FPN, FPN :-: Fe2, Fe2 :+: Ferroptosis Validated 0 _NA_ Q9P2H5 33931967 _NA_ 2022/1/26 FerrDb team 212 Ferroptosis HSF1 HGNC:5224 HSF1 inhibition sensitizes cancer cells to ferroptotic cell death. Human HSF1 :+: PROM2, PROM2 :-: Ferroptosis Validated 0 _NA_ Q00613 34223704 _NA_ 2022/2/12 FerrDb team 213 Ferroptosis PROM2 HGNC:20685 Together, these data indicate that cells can resist ferroptosis by activating p38 and, consequently, inducing prominin2. Human PROM2 :-: Ferroptosis Validated 0 _NA_ Q8N271 34223704 _NA_ 2022/2/12 FerrDb team 214 Ferroptosis PLA2G6 HGNC:9039 These results demonstrate that iPLA2β acts as a major ferroptosis repressor in a GPX4-independent manner. Human PLA2G6 :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ O60733 34131139 iPLA2β in article. 2022/2/23 FerrDb team 215 Ferroptosis HIF1A HGNC:4910 Knock-down of HIF-1α increases free iron level, promotes mitochondrial iron accumulation and induces ferroptosis under hypoxia. Human HIF1A :-: iron accumulation, iron accumulation :+: Ferroptosis, HIF1A :-: Lpid ROS, Lipid ROS :+: Ferroptosis, HIF1A :-: PTGS2, PTGS2 :+: Ferroptosis, HIF1A :-: MDA, MDA :+: Ferroptosis, HIF1A :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q16665 33895289 HIF-1α in article. 2022/2/24 FerrDb team 216 Ferroptosis NEAT1 HGNC:30815 NEAT1 knockdown and overexpression greatly increased and decreased cell death (TUNEL staining, p < 0.05;Figure 2b, c), respectively, and affected MDA levels (p < 0.05; Figure 2d) in A549 cells, further confirming the link between NEAT1 and ferroptosis induction. Human NEAT1 :-: Ferroptosis Validated 0 _NA_ _NA_ 33730930 Long non-coding RNA. 2022/2/24 FerrDb team 217 Ferroptosis RRM2 HGNC:10452 Identification of critical ferroptosis regulators in lung adenocarcinoma that RRM2 facilitates tumor immune infiltration by inhibiting ferroptotic death. Human RRM2 :+: glutathione, glutathione :-: Ferroptosis, RRM2 :-: iron accumulation, iron accumulation :+: Ferroptosis, RRM2 :-: Lipid ROS, Lpid ROS :+: Ferroptosis, RRM2 :-: MDA, MDA :+: Ferroptosis Validated 0 _NA_ P31350 34648954 _NA_ 2022/2/24 FerrDb team 218 Ferroptosis SLC7A11 HGNC:11059 xCT inhibition induces MF-HSC ferroptosis. Human SC7A11 :+: GSH, GSH :-: Ferroptosis, SC7A11 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, SC7A11 :-: CHAC1, CHAC1 :+: Ferroptosis, SC7A11 :-: PTGS2, PTGS2 :+: Ferroptosis Validated 0 _NA_ Q9UPY5 33991158 xCT in article. 2022/3/2 FerrDb team 219 Ferroptosis FTMT HGNC:17345 Overexpression of FtMt reduced osteoblastic ferroptosis under high glucose condition while silent FtMt induced mitophagy through ROS / PINK1/Parkin pathway. Rat FTMT :-: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ Q8N4E7 33594527 _NA_ 2022/3/2 FerrDb team 220 Ferroptosis PARP1 HGNC:270 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP1 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ P09874 33722571 _NA_ 2022/3/2 FerrDb team 221 Ferroptosis PARP2 HGNC:272 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP2 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q9UGN5 33722571 _NA_ 2022/3/2 FerrDb team 222 Ferroptosis PARP3 HGNC:273 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP3 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q9Y6F1 33722571 _NA_ 2022/3/2 FerrDb team 223 Ferroptosis PARP4 HGNC:271 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP4 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q9UKK3 33722571 _NA_ 2022/3/2 FerrDb team 224 Ferroptosis PARP6 HGNC:26921 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP6 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q2NL67 33722571 _NA_ 2022/3/2 FerrDb team 225 Ferroptosis PARP8 HGNC:26124 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP8 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q8N3A8 33722571 _NA_ 2022/3/2 FerrDb team 226 Ferroptosis PARP9 HGNC:24118 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP9 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q8IXQ6 33722571 _NA_ 2022/3/2 FerrDb team 227 Ferroptosis PARP10 HGNC:25895 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP10 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q53GL7 33722571 _NA_ 2022/3/2 FerrDb team 228 Ferroptosis PARP11 HGNC:1186 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP11 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q9NR21 33722571 _NA_ 2022/3/2 FerrDb team 229 Ferroptosis PARP12 HGNC:21919 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP12 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q9H0J9 33722571 _NA_ 2022/3/2 FerrDb team 230 Ferroptosis PARP14 HGNC:29232 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP14 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q460N5 33722571 _NA_ 2022/3/2 FerrDb team 231 Ferroptosis PARP15 HGNC:26876 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP15 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q460N3 33722571 _NA_ 2022/3/2 FerrDb team 232 Ferroptosis PARP16 HGNC:26040 PARP inhibition promotes ferroptosis in ovarian cancer cells. Human PARP16 :+: SLC7A11, SLC7A11 :+: glutathione biosynthesis, glutathione biosynthesis :-: Lipid ROS, Lipid ROS :+: Ferroptosis Deduced 0 _NA_ Q8N5Y8 33722571 _NA_ 2022/3/2 FerrDb team 233 Ferroptosis PDSS2 HGNC:23041 PDSS2 Inhibits the Ferroptosis of Vascular Endothelial Cells in Atherosclerosis by Activating Nrf2. Human PDSS2 :+: Nrf2, Nrf2 :-: iron content, iron content :+: Ferroptosis, PDSS2 :+: Nrf2, Nrf2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, PDSS2 :+: Nrf2, Nrf2 :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q86YH6 33929387 _NA_ 2022/3/2 FerrDb team 234 Ferroptosis TXN HGNC:12435 Our results suggest that Trx-1 inhibits ferroptosis in PD through regulating GPX4 and GSH. Mice TXN :+: GPX4, GPX4 :-: Ferroptosis, TXN :+: GSH, GSH :-: Ferroptosis, TXN :-: Lpid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P10599 33634378 Thioredoxin-1 in article. 2022/3/2 FerrDb team 235 Ferroptosis SENP1 HGNC:17927 SENP1 overexpression suppresses ferroptotic cell death of H9c2 cells. Rat SENP1 :-: Lpid ROS, Lpid ROS :+: Ferroptosis, SENP1 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ Q9P0U3 33746578 _NA_ 2022/3/3 FerrDb team 236 Ferroptosis PLA2G6 HGNC:9039 Phospholipase iPLA2β Averts Ferroptosis By Eliminating A Redox Lipid Death Signal. Human, mice PLA2G6 :-: Ferroptosis Validated 0 _NA_ O60733 33542532 iPLA2β in article. 2022/3/3 FerrDb team 237 Ferroptosis OIP5-AS1 HGNC:43563 LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling. Human OIP5-AS1 :-: miR-128-3p, miR-128-3p :-: SLC7A11, SLC7A11 :-: Ferroptosis, OIP5-AS1 :-: Fe2, Fe2 :+: Ferroptosis, OIP5-AS1 :-: iron content, iron content :+: Ferroptosis, OIP5-AS1 :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ _NA_ 34051661 Long non-coding RNA. 2022/3/3 FerrDb team 238 Ferroptosis MIR190A HGNC:31560 miR-190a-5p inhibits ferroptosis induced by erastin and RSL3 in H9c2 cells. Human miR-190a-5p :-: GLS2, GLS2 :+: Lpid ROS, Lipid ROS :+: Ferroptosis, miR-190a-5p :-: GLS2, GLS2 :+: MDA, MDA :+: Ferroptosis, miR-190a-5p :-: GLS2, GLS2 :+: Fe2 accumulation, Fe2 accumulation :+: Ferroptosis Validated 0 _NA_ _NA_ 34111670 miR-190a-5p in article. 2022/3/3 FerrDb team 239 Ferroptosis FGF21 HGNC:3678 FGF21 attenuates ferroptosis by promoting HO-1 ubiquitination and degradation. Mice FGF21 :+: FPN, FPN :-: Fe2+, Fe2+ :+: Ferroptosis, FGF21 :+: FTH, FTH :-: Fe2+, Fe2+ :+: Ferroptosis, FGF21 :+: FTL, FTL :-: Fe2+, Fe2+ :+: Ferroptosis, FGF21 :+: GPX4, GPX4 :-: Ferroptosis, FGF21 :+: NRF2, NRF2 :-: Ferroptosis, FGF21 :-: PTGS2, PTGS2 :+: Ferroptosis, FGF21 :-: Lipid ROS, Lpid ROS :+: Ferroptosis, FGF21 :-: MDA, MDA :+: Ferroptosis, FGF21 :+: GSH, GSH :-: Ferroptosis, FGF21 :-: HO-1, HO-1 :+: Ferroptosis, FGF21 :+: SLC7A11, SLC7A11 :-: Ferroptosis, FGF21 :+: FTH, FTH :-: Fe2+, Fe2+ :+: Ferroptosis Validated 0 _NA_ Q9NSA1 34530349 _NA_ 2022/3/7 FerrDb team 240 Ferroptosis CREB1 HGNC:2345 CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma. Human CREB1 :+: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P16220 33846793 CREB in article. 2022/3/7 FerrDb team 241 Ferroptosis CREB3 HGNC:2347 CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma. Human CREB3 :+: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ O43889 33846793 CREB in article. 2022/3/7 FerrDb team 242 Ferroptosis CREB5 HGNC:16844 CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma. Human CREB5 :+: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ Q02930 33846793 CREB in article. 2022/3/7 FerrDb team 243 Ferroptosis FTMT HGNC:17345 FtMt deletion aggravates cerebral I/R-induced ferroptosis. Mice FTMT :+: GPX4, GPX4 :-: Ferroptosis, FTMT :+: GSH, GSH :-: Ferroptosis, FTMT :-: Lipid ROS, Lipid ROS :+: Ferroptosis, FTMT :+: FPN1, FPN1 :-: Fe2, Fe2 :+: Ferroptosis Validated 0 _NA_ Q8N4E7 33953171 _NA_ 2022/3/8 FerrDb team 244 Ferroptosis GOT1 HGNC:4432 GOT1 suppression potentiates ferroptosis sensitivity. Human GOT1 :-: labile iron, labile iron :+: Ferroptosis Validated 0 _NA_ P17174 34381026 _NA_ 2022/3/8 FerrDb team 245 Ferroptosis TFRC HGNC:11763 Tfr1 deletion activates ferroptosis in skeletal muscle upon muscular regeneration. Mice TFRC :+: GPX4, GPX4 :-: Ferroptosis, TFRC :+: GSH, GSH :-: Ferroptosis, TFRC :-: MDA, MDA :+: Ferroptosis, TFRC :-: Lpid ROS, Lipid ROS :+: Ferroptosis, TFRC :-: Labile iron, Labile iron :+: Ferroptosis Validated 0 _NA_ P02786 33955709 Tfr1 in article. 2022/3/8 FerrDb team 246 Ferroptosis GPX4 HGNC:4556 GPX4 deficiency induces HSPC ferroptosis in vitro. Mice GPX4 :-: Lpid ROS, Lpid ROS :+: Ferroptosis Validated 0 _NA_ P36969 34267193 _NA_ 2022/3/8 FerrDb team 247 Ferroptosis MIR130B HGNC:31515 miR-130b-3p suppresses erastin or RSL3-induced ferroptosis in melanoma cells. Human miR-130b-3p :-: DKK1, DKK1 :-: Nrf2/HO-1 pathway, Nrf2/HO-1 pathway :-: Ferroptosis, miR-130b-3p :-: Lipid ROS, Lpid ROS :+: Ferroptosis, miR-130b-3p :-: iron accumulation, iron accumulation :+: Ferroptosis Validated 0 _NA_ _NA_ 34117611 miR-130b-3p in article 2022/3/10 FerrDb team 248 Ferroptosis BEX1 HGNC:1036 Taken together, these findings demonstrate that BEX1 promotes cell survival in adrenal cells by mediating the inhibition of ferroptosis and suggest a function for BEX1 in the pathogenesis of APAs. Human BEX1 :-: Ferroptosis Validated 0 _NA_ Q9HBH7 33745298 _NA_ 2022/3/10 FerrDb team 254 Ferroptosis ASAH2 HGNC:18860 Our data thus indicate the Asah2 represses Hmox1 expression to reduce lipid ROS to suppress ferroptosis. Mice ASAH2 :-: p53, p53 :+: Hmox1, Hmox1 :+: Lipid ROS, Lipid ROS :+: Ferroptosis, ASAH2 :-: p53, p53 :-: GSH, GSH :-: Ferroptosis Validated 0 _NA_ Q9NR71 33547170 _NA_ 2022/3/15 FerrDb team 255 Ferroptosis SCD HGNC:10571 Mechanistically, SCD1 leads to fatty acid (FA) desaturation and FABP4 derived from TEM enhances lipid droplet (LD) in cancer cells, which cooperatively protect from oxidative stress-induced ferroptosis. Mice SCD :-: Ferroptosis Validated 0 Ortholog mice gene O00767 34030117 SCD1 in article. 2022/3/15 FerrDb team 256 Ferroptosis FABP4 HGNC:3559 Mechanistically, SCD1 leads to fatty acid (FA) desaturation and FABP4 derived from TEM enhances lipid droplet (LD) in cancer cells, which cooperatively protect from oxidative stress-induced ferroptosis. Human FABP4 :-: Ferroptosis Validated 0 _NA_ P15090 34030117 _NA_ 2022/3/15 FerrDb team 257 Ferroptosis AKT1S1 HGNC:28426 mTORC1 inhibition sensitizes cancer cells or tumors to ferroptosis. Human AKT1S1 :-: Ferroptosis Deduced 0 _NA_ Q96B36 33707434 mTORC1 in article. mTORC1 exists as a multiprotein complex consisting of mTOR, Raptor, and other proteins. 2022/3/15 FerrDb team 258 Ferroptosis MLST8 HGNC:24825 mTORC1 inhibition sensitizes cancer cells or tumors to ferroptosis. Human MLST8 :-: Ferroptosis Deduced 0 _NA_ Q9BVC4 33707434 mTORC1 in article. mTORC1 exists as a multiprotein complex consisting of mTOR, Raptor, and other proteins. 2022/3/15 FerrDb team 259 Ferroptosis MTOR HGNC:3942 mTORC1 inhibition sensitizes cancer cells or tumors to ferroptosis. Human MTOR :-: Ferroptosis Deduced 0 _NA_ P42345 33707434 mTORC1 in article. mTORC1 exists as a multiprotein complex consisting of mTOR, Raptor, and other proteins. 2022/3/15 FerrDb team 260 Ferroptosis RPTOR HGNC:30287 mTORC1 inhibition sensitizes cancer cells or tumors to ferroptosis. Human RPTOR :-: Ferroptosis Deduced 0 _NA_ Q8N122 33707434 mTORC1 in article. mTORC1 exists as a multiprotein complex consisting of mTOR, Raptor, and other proteins. 2022/3/15 FerrDb team 261 Ferroptosis CDH1 HGNC:1748 These results indicate that the inhibition of E-cadherin or the induction of EMT enhance ferroptosis. Human CDH1 :-: Lipid ROS, Lpid ROS :+: Ferroptosis, CDH1 :-: Fe2, Fe2 :+: Ferroptosis Validated 0 _NA_ P12830 34801472 E-cadherin in article. 2022/3/15 FerrDb team 262 Ferroptosis SIRT1 HGNC:14929 SIRT1 inhibits FCs ferroptosis in excess iron. Human SIRT1 :-: Lpid ROS, Lipid ROS :+: Ferroptosis, SIRT1 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q96EB6 34000515 _NA_ 2022/3/16 FerrDb team 263 Ferroptosis TYRO3 HGNC:12446 Inhibition of TYRO3 enhances ferroptosis and sensitizes resistant tumors to anti-mPD-1 therapy. Human, mice TYRO3 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, TYRO3 :+: AKT, AKT :+: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ Q06418 33855973 _NA_ 2022/3/16 FerrDb team 264 Ferroptosis SIRT6 HGNC:14934 SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer. Human SIRT6 :+: GPX4, GPX4 :-: Ferroptosis, SIRT6 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, SIRT6 :-: Fe2+, Fe2+ :+: Ferroptosis, SIRT6 :-: MDA, MDA :+: Ferroptosis, SIRT6 :+: GSH, GSH :-: Ferroptosis, SIRT6 :+: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ Q8N6T7 34530350 _NA_ 2022/3/16 FerrDb team 265 Ferroptosis TMSB4X HGNC:11881 Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4. Human, rat TMSB4X :-: Lpid ROS, Lipid ROS :+: Ferroptosis, TMSB4X :-: MDA, MDA :+: Ferroptosis, TMSB4X :+: GSH, GSH :-: Ferroptosis, TMSB4X :+: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P62328 34280397 Tβ4 in article. 2022/3/16 FerrDb team 266 Ferroptosis TMSB4Y HGNC:11882 Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4. Human, rat TMSB4Y :-: Lpid ROS, Lipid ROS :+: Ferroptosis, TMSB4Y :-: MDA, MDA :+: Ferroptosis, TMSB4Y :+: GSH, GSH :-: Ferroptosis, TMSB4Y :+: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ O14604 34280397 Tβ4 in article. 2022/3/16 FerrDb team 267 Ferroptosis KIF20A HGNC:9787 High KIF20A expression in resistant CRC cell line suppressed the intracellular ferroptosis process. Human KIF20A :+: NUAK1, NUAK1 :+: NRF2, NRF2 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ O95235 33819186 _NA_ 2022/3/16 FerrDb team 268 Ferroptosis ECH1 HGNC:3149 Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis. Human, mice ECH1 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q13011 33813878 _NA_ 2022/3/16 FerrDb team 272 Ferroptosis circRHOT1 _NA_ Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer. Human circRHOT1 :-: miR-106a-5p, miR-106a-5p :-: STAT3, STAT3 :-: Ferroptosis Validated 0 _NA_ _NA_ 33686957 _NA_ 2022/3/20 FerrDb team 273 Ferroptosis ETV4 HGNC:3493 Overall, the data suggested that the knockdown of ETV4 suppressed the PTC progression by promoting ferroptosis upon SLC7A11 downregulation. Human ETV4 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P43268 34283663 _NA_ 2022/3/21 FerrDb team 274 Ferroptosis MEG8 HGNC:14574 Silencing lncRNA MEG8 inhibits the proliferation and induces the ferroptosis of HemECs. Human MEG8 :-: MDA, MDA :+: Ferroptosis, MEG8 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, MEG8 :+: GPX4, GPX4 :-: Ferroptosis, MEG8 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ _NA_ 33839417 A long non-coding RNA. 2022/3/21 FerrDb team 275 Ferroptosis VCP HGNC:12666 VCP relocalization limits mitochondrial activity, GSH depletion and ferroptosis during starvation in PC3 prostate cancer cells. Moreover, the addition of a VCP inhibitor, CB-5083, in starvation media prevented VCP relocalization and triggered ferroptotic cell death. Human VCP :+: GSH, GSH :-: Ferroptosis Validated 0 _NA_ P55072 34033175 _NA_ 2022/3/21 FerrDb team 276 Ferroptosis circ_0007142 _NA_ After expression inhibition of circ_0007142, proliferation was reduced, while apoptosis and ferroptosis were facilitated in CRC cells. Human circ_0007142 :-: miR-874-3p, miR-874-3p :-: GDPD5 ,GDPD5 :-: Ferroptosis Validated 0 _NA_ _NA_ 33797091 _NA_ 2022/3/21 FerrDb team 277 Ferroptosis ENPP2 HGNC:3357 These data suggested the inhibitory effects of ENPP2 on DOX-induced ferroptosis in H9c2 cells. Rats ENPP2 :-: Fe2+, Fe2+ :+: Ferroptosis, ENPP2 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, ENPP2 :+: SLC7A11, SLC7A11 :-: Ferroptosis, ENPP2 :+: GPX4, GPX4 :-: Ferroptosis, ENPP2 :+: FPN1, FPN1 :-: iron accumulation, iron accumulation :+: Ferroptosis, ENPP2 :-: NOX4, NOX4 :+: Ferroptosis Validated 0 _NA_ Q13822 34296293 _NA_ 2022/3/22 FerrDb team 278 Ferroptosis RBMS1 HGNC:9907 RBMS1 ablation inhibited the translation of SLC7A11, reduced SLC7A11-mediated cystine uptake, and promoted ferroptosis. Human RBMS1 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P29558 34609966 _NA_ 2022/3/30 FerrDb team 279 Ferroptosis KDM4A HGNC:22978 KDM4A knockdown promotes ferroptosis in OS cells. Human KDM4A :-: lipid peroxidation, lipid peroxidation :+: Ferroptosis, KDM4A :+: GSH, GSH :-: Ferroptosis, KDM4A :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ O75164 33689883 _NA_ 2022/3/30 FerrDb team 280 Ferroptosis CBS HGNC:1550 CBS Protects BLBC Tumors from Oxidative Stress and Ferroptotic Cell Death. Human CBS :-: Ferroptosis Validated 0 _NA_ P35520 34737229 _NA_ 2022/3/30 FerrDb team 281 Ferroptosis MGST1 HGNC:7061 MGST1 inhibits ferroptosis in vivo. Human MGST1 :-: ALOX5, ALOX5 :+: Lipid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ P10620 33539732 _NA_ 2022/3/30 FerrDb team 282 Ferroptosis circKIF4A _NA_ Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer. Human circKIF4A :-: miR-1231, miR-1231 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 34153004 _NA_ 2022/3/30 FerrDb team 283 Ferroptosis miR-7-5p _NA_ Knockdown of miR-7-5p Enhances Ferroptosis Signaling. Human miR-7-5p :-: ALOX12, ALOX12 :+: Lpid ROS, Lipid ROS :+: Ferroptosis Validated 0 _NA_ _NA_ 34361070 _NA_ 2022/3/30 FerrDb team 284 Ferroptosis PRDX6 HGNC:16753 Prdx6 overexpression also eliminated ferroptosis caused by HG, which was reflected in the suppression of iron accumulation and the increase in SLC7A11 and GPX4 expression. Mice PRDX6 :-: Lipid ROS, Lipid ROS :+: Ferroptosis, PRDX6 :+: GSH, GSH :-: Ferroptosis, PRDX6 :+: GPX4,GPX4 :-: Ferroptosis, PRDX6 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P30041 33894270 _NA_ 2022/3/30 FerrDb team 285 Ferroptosis circ_0067934 _NA_ Circular RNA Circ_0067934 Attenuates Ferroptosis of Thyroid Cancer Cells by miR-545-3p/SLC7A11 Signaling. Human circ_0067934 :-: miR-545-3p, miR-545-3p :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ _NA_ 34290668 _NA_ 2022/3/30 FerrDb team 286 Ferroptosis MPC1 HGNC:21606 Taken together, our data suggested that MPC1 suppression increased vulnerability to ferroptosis in vivo. Human MPC1 :-: Ferroptosis Validated 0 _NA_ Q9Y5U8 33741422 _NA_ 2022/3/30 FerrDb team 287 Ferroptosis CHMP1A HGNC:8740 Chmp1a knockdown enhances ferroptosis through increased iron accumulation. Mice CHMP1A :-: Ferroptosis Validated 0 _NA_ Q9HD42 34426578 _NA_ 2022/3/30 FerrDb team 288 Ferroptosis CAMKK2 HGNC:1470 Then we proved that CAMKK2 negatively regulated ferroptosis through the activation of NRF2 and the suppression of lipid peroxidation. Human CAMKK2 :+: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ Q96RR4 34242660 _NA_ 2022/3/30 FerrDb team 289 Ferroptosis SOX2 HGNC:11195 Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11. Human, mice SOX2 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P48431 34385181 _NA_ 2022/3/31 FerrDb team 290 Ferroptosis SRSF9 HGNC:10791 Furthermore, we found that SRSF9 inhibition increased erastin-induced ferroptosis by downregulating GPX4 level. Human SRSF9 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q13242 33609745 _NA_ 2022/3/31 FerrDb team 291 Ferroptosis PROK2 HGNC:18455 Thus, Prok2 overexpression alleviates ferroptosis by promoting expression of Fbxo10 and accelerating Acsl4 ubiquitination/degradation. Mice PROK2 :+: GPX4, GPX4 :-: Ferroptosis, PROK2 :+: FBXO10, FBXO10 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ Q9HC23 34244497 _NA_ 2022/3/31 FerrDb team 317 Ferroptosis MIR4443 HGNC:41830 miR-4443 promotes cisplatin resistance by suppressing ferroptosis. Human MIR4443 :-: METTL3, METTL3 :-: FSP1, FSP1 :-: Ferroptosis Validated 0 _NA_ _NA_ 33781830 _NA_ 2022/4/6 FerrDb team 318 Ferroptosis SIRT2 HGNC:10886 SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury. Mice SIRT2 :-: p53, p53 :+: Ferroptosis Validated 0 _NA_ Q8IXJ6 34102645 _NA_ 2022/4/6 FerrDb team 319 Ferroptosis circRNA1615 _NA_ circRNA1615 inhibits ferroptosis via modulation of autophagy by the miRNA152-3p/LRP6 molecular axis in cardiomyocytes of myocardial infarction. Mice circRNA1615 :-: miR-152-3p, miR-152-3p :-: LRP6, LRP6 :-: Ferroptosis Validated 0 _NA_ _NA_ 34712388 _NA_ 2022/4/6 FerrDb team 320 Ferroptosis MIR27A HGNC:31613 Cell viability was reduced after downregulating miR-27a-3p in comparison with control (Figure 5A), suggesting that miR-27a-3p negatively modulated ferroptosis. Human MIR27A :-: SLC7A11, SLC7A11 :+: Ferroptosis Validated 0 _NA_ _NA_ 34722314 _NA_ 2022/4/6 FerrDb team 321 Ferroptosis MIR670 HGNC:37304 MicroRNA-670-3p suppresses ferroptosis of human glioblastoma cells through targeting ACSL4. Human MIR670 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ _NA_ 34323631 _NA_ 2022/4/7 FerrDb team 322 Ferroptosis MEF2C HGNC:6996 MEF2C Inhibited Ferroptosis by Upregulating NF2 and E-Cadherin. Human MEF2C :+: NF2, NF2 :-: Ferroptosis, MEF2C :+: E-Cadherin, E-Cadherin :-: Ferroptosis Validated 0 _NA_ Q06413 33984142 _NA_ 2022/4/7 FerrDb team 323 Ferroptosis NF2 HGNC:7773 Together, these results suggest that loss of NF2 might sensitize meningioma to ferroptosis-induced cytotoxicity. Human NF2 :+: GPX4, GPX4 :-: Ferroptosis, NF2 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ P35240 33984142 _NA_ 2022/4/7 FerrDb team 324 Ferroptosis CDH1 HGNC:1748 E-Cadherin Induced Cell Density-Dependent Inhibition of Ferroptosis. Human CDH1 :+: GPX4, GPX4 :-: Ferroptosis, CDH1 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ P12830 33984142 E-Cadherin in article. 2022/4/7 FerrDb team 325 Ferroptosis HSPB1 HGNC:5246 HSP27 protects against ferroptosis of glioblastoma cells. Human HSPB1 :+: SLC7A11, SLC7A11 :-: Ferroptosis, HSPB1 :+: HO-1, HO-1 :-: Ferroptosis Validated 0 _NA_ P04792 34791597 HSP27 in article. 2022/4/7 FerrDb team 326 Ferroptosis EZH2 HGNC:3527 Overexpression of EZH2 and SLC7A11 inhibits erastin-induced ferroptosis in TSCC cells. Human EZH2 :-: miR-125b-5p, miR-125b-5p :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q15910 34614259 _NA_ 2022/4/7 FerrDb team 327 Ferroptosis PEDS1 HGNC:16735 TMEM189 promotes ferroptosis resistance via inhibiting expression of FAR1 through plasmalogen synthesis. Human PEDS1 :-: FAR1, FAR1 :+: Ferroptosis Validated 0 _NA_ A5PLL7 33731874 TMEM189 in article. 2022/4/7 FerrDb team 328 Ferroptosis SMPD1 HGNC:11120 Together, knockdown of Smpd1 and Taz expression responsible for CER and CL synthesis, respectively, aggravated APAP-induced mitochondrial dysfunction and ferroptosis in hepatocytes. Mice SMPD1 :-: Ferroptosis Validated 0 _NA_ P17405 34401974 _NA_ 2022/4/7 FerrDb team 329 Ferroptosis ADAMTS13 HGNC:1366 We found that ADAMTS13 alleviated CP-induced ferroptosis in AKI mice with renal function impairment and tubular damage. Mice ADAMTS13 :+: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ Q76LX8 34666603 _NA_ 2022/4/8 FerrDb team 330 Ferroptosis CDC25A HGNC:1725 Overexpression of Cdc25A suppressed ferroptosis in cervical cancer cells. Human CDC25A :+: ERBB2, ERBB2 :-: Ferroptosis Validated 0 _NA_ P30304 34743185 _NA_ 2022/4/8 FerrDb team 331 Ferroptosis G6PD HGNC:4057 G6PD inhibits ferroptosis in HCC cells. Human G6PD :-: POR, POR :+: Ferroptosis Validated 0 _NA_ P11413 34325001 _NA_ 2022/4/8 FerrDb team 332 Ferroptosis SFRS9 HGNC:10791 Knockdown of SFRS9 Inhibits Progression of Colorectal Cancer Through Triggering Ferroptosis Mediated by GPX4 Reduction. Human SFRS9 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q13242 34336668 _NA_ 2022/4/8 FerrDb team 333 Ferroptosis CAV HGNC:1527 Higher expression of CAV1 inhibits ferroptosis of cancer cells in HNSCC. Human CAV :-: Ferroptosis Validated 0 _NA_ Q03135 34874578 _NA_ 2022/4/10 FerrDb team 334 Ferroptosis CircFNDC3B _NA_ CircFNDC3B Represses Ferroptosis of OSCC Cells by Inducing SLC7A11 Expression. Mice CircFNDC3B :-: miR-520d-5p, miR-520d-5p :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ _NA_ 34434890 _NA_ 2022/4/10 FerrDb team 335 Ferroptosis PPARD HGNC:9235 GW501516-activated PPARδ attenuates ferroptotic death of xCT-deficient MEFs. Mice PPARD :+: catalase, catalase :-: H2O2, H2O2 :+: Ferroptosis Validated 0 _NA_ Q03181 34649350 _NA_ 2022/4/11 FerrDb team 336 Ferroptosis CISD2 HGNC:24212 Knockdown of CISD2 Promotes Ferroptosis in Sorafenib-Resistant Cells. Human CISD2 :-: Beclin 1, Beclin 1 :+: Ferroptosis Validated 0 _NA_ Q8N5K1 34485112 _NA_ 2022/4/12 FerrDb team 337 Ferroptosis ENO3 HGNC:3354 In addition, overexpressed ENO3 attenuated the status of ferroptosis. Mice ENO3 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ P13929 33987359 _NA_ 2022/4/12 FerrDb team 338 Ferroptosis SESN2 HGNC:20746 Sesn2 suppresses septic-induced ferroptosis to improve the immune function of DCs. Mice SESN2 :-: (ATF4/CHOP/CHAC1), (ATF4/CHOP/CHAC1) :+: Ferroptosis Validated 0 _NA_ P58004 34482365 _NA_ 2022/4/12 FerrDb team 339 Ferroptosis LCN2 HGNC:6526 LIFR and SHP1 positively regulate ferroptosis while LCN2 negatively regulates ferroptosis. Human LCN2 :-: Ferroptosis Validated 0 _NA_ P80188 34921145 _NA_ 2022/4/12 FerrDb team 1264 Ferroptosis MARCHF5 HGNC:26025 Further, in cultured cardiomyocytes stressed with DOX, both MITOL and GPX4 were reduced, whereas forced-expression of MITOL suppressed DOX-induced ferroptosis by maintaining GPX4 content. Rat MARCHF5 :+: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q9NX47 34390730 MITOL in article. 2022/4/17 FerrDb team 1265 Ferroptosis TRIB2 HGNC:30809 Here, we demonstrated that deletion of TRIB2 sensitized ferroptosis via lifting labile iron in liver cancer cells. Human TRIB2 :-: TFRC, TFRC :+: Ferroptosis Validated 0 _NA_ Q92519 34315867 _NA_ 2022/4/17 FerrDb team 1266 Ferroptosis DHODH HGNC:2867 DHODH inhibits mitochondrial ferroptosis. Human DHODH :+: CoQ/CoQH2 ratio, CoQ/CoQH2 ratio :-: Ferroptosis Validated 0 _NA_ Q02127 33981038 _NA_ 2022/4/18 FerrDb team 1267 Ferroptosis SLC7A11 HGNC:11059 SLC7A11 Overexpression Induces Ferroptosis Resistance. Human, mice SLC7A11 :+: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ Q9UPY5 33681224 _NA_ 2022/4/18 FerrDb team 1268 Ferroptosis MIR545 HGNC:32531 These data suggest that miR-545 may increase CRC cell survival by inhibiting ferroptosis. Human MIR545 :-: TF, TF :+: Ferroptosis Validated 0 _NA_ _NA_ 34954694 _NA_ 2022/4/18 FerrDb team 1269 Ferroptosis OTUB1 HGNC:23077 OTUB1 knockdown triggers ferroptosis dependent on SLC7A11 expression. Human OTUB1 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q96FW1 34927544 _NA_ 2022/4/18 FerrDb team 1270 Ferroptosis PDK4 HGNC:8812 PDK4 inhibits ferroptosis by blocking pyruvate dehydrogenase-dependent pyruvate oxidation. Human PDK4 :-: pyruvate oxidation, pyruvate oxidation :+: Ferroptosis Validated 0 _NA_ Q16654 33626342 _NA_ 2022/4/18 FerrDb team 1271 Ferroptosis CircPVT1 _NA_ Furthermore, knockdown of circPVT1 increased ferroptosis through downregulating p-β-catenin, GPX4, and SLC7A11 while miR-30a-5p inhibition and FZD3 overexpression reversed the phenotype by upregulating p-β-catenin, GPX4, and SLC7A11. Human CircPVT1 :-: MiR-30a-5p, MiR-30a-5p :-: FZD3, FZD3 :-: Ferroptosis Validated 0 _NA_ _NA_ 34966683 _NA_ 2022/4/18 FerrDb team 1369 Ferroptosis MIR9-3HG HGNC:27388 BMSCs-Exo Mir9-3hg attenuates H/R-induced ferroptosis in HL-1 cells. Mice MIR9-3HG :-: PUM2, PUM2 :-: PRDX6, PRDX6 :-: Ferroptosis Validated 0 _NA_ _NA_ 34953631 _NA_ 2022/4/24 FerrDb team 1370 Ferroptosis ADIPOQ HGNC:13633 ADPN inhibited oxidation/peroxide imbalance-induced ferroptosis in placental tissues of GDM mice. Mice ADIPOQ :-: CPT-1, CPT-1 :+: Ferroptosis, ADIPOQ :-: GLUT4, GLUT4 :+: Ferroptosis Validated 0 _NA_ Q15848 34859390 adiponectin (ADPN) in article. 2022/4/25 FerrDb team 1371 Ferroptosis circDTL _NA_ Inhibition of circDTL Induced Apoptosis and Ferroptosis in NSCLC Cells. Human circDTL :-: miR-1287-5p, miR-1287-5p :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 34621297 _NA_ 2022/4/25 FerrDb team 1372 Ferroptosis GPX4 HGNC:4556 The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Mice GPX4 :-: Ferroptosis Validated 0 _NA_ P36969 34133924 _NA_ 2022/4/25 FerrDb team 1373 Ferroptosis mmu_circRNA_0000309 _NA_ mmu_circRNA_0000309 depletion abrogates the inhibitory effect of germacrone on ferroptosis. Mice mmu_circRNA_0000309 :-: miR-188-3p, miR-188-3p :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ _NA_ 34913724 _NA_ 2022/5/5 FerrDb team 1374 Ferroptosis IL6 HGNC:6018 IL-6 reverses ferroptosis in vivo and in vitro by upregulating xCT. Human IL6 :+: (JAK2/STAT3), (JAK2/STAT3) :+: xCT, xCT :-: Ferroptosis Validated 0 _NA_ P05231 34902522 _NA_ 2022/5/5 FerrDb team 1375 Ferroptosis PTPN18 HGNC:9649 In the present study, we found that silencing of PTPN18 induced ferroptosis in KLE endometrial cancer cells. Human PTPN18 :-: p-P38, p-P38 :-: GPX4, GPX4 :-: Ferroptosis Validated 0 _NA_ Q99952 33642877 _NA_ 2022/5/5 FerrDb team 1376 Ferroptosis FTH1 HGNC:3976 FTH expression endows HCC cells specifically resistant to ferroptosis. Human FTH1 :-: Ferroptosis Validated 0 _NA_ P02794 34965856 _NA_ 2022/5/5 FerrDb team 1377 Ferroptosis FTH1 HGNC:3976 Meanwhile, we also showed that apoferritin prevented MPTP-induced ferroptosis effectively by inhibiting the up-regulation of long-chain acyl-CoA synthetase 4 (ACSL4) and the down-regulation of ferroptosis suppressor protein 1 (FSP1). Human FTH1 :-: ACSL4, ACSL4 :+: Ferroptosis Validated 0 _NA_ P02794 33997705 Apoferritin in article. 2022/5/5 FerrDb team 1378 Ferroptosis FTL HGNC:3999 Meanwhile, we also showed that apoferritin prevented MPTP-induced ferroptosis effectively by inhibiting the up-regulation of long-chain acyl-CoA synthetase 4 (ACSL4) and the down-regulation of ferroptosis suppressor protein 1 (FSP1). Human FTL :+: FSP1, FSP1 :-: Ferroptosis Validated 0 _NA_ P02792 33997705 Apoferritin in article. 2022/5/5 FerrDb team 1379 Ferroptosis LCN2 HGNC:6526 hLcn-2 Protects Renal Tumor Cells against Erastin-Induced Ferroptotic Cell Death. Human LCN2 :+: integrated stress response (ISR), integrated stress response (ISR) :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P80188 34069743 _NA_ 2022/5/5 FerrDb team 1380 Ferroptosis ABCC5 HGNC:56 ABCC5 increased intracellular glutathione (GSH) and attenuated lipid peroxidation accumulation by stabilizing SLC7A11 protein, which inhibited ferroptosis. Human ABCC5 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ O15440 34768109 _NA_ 2022/5/11 FerrDb team 1381 Ferroptosis CISD3 HGNC:27578 CISD3 inhibition drives cystine-deprivation induced ferroptosis. Human CISD3 :-: Ferroptosis Validated 0 _NA_ P0C7P0 34497268 _NA_ 2022/5/11 FerrDb team 1382 Ferroptosis MS4A15 HGNC:28573 Ms4a15 expression specifically blocks ferroptosis. Mice MS4A15 :-: Ferroptosis Validated 0 _NA_ Q8N5U1 34663908 _NA_ 2022/5/11 FerrDb team 1383 Ferroptosis LCN2 HGNC:6526 Lipocalin 2 expression promotes tumor progression and therapy resistance by inhibiting ferroptosis in colorectal cancer. Human LCN2 :+: ETS1, ETS1 :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ P80188 34146401 _NA_ 2022/5/11 FerrDb team 1384 Ferroptosis FURIN HGNC:8568 Furin protects epithelial cells from DSS-induced ferroptosis-like cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway. Human, mice FURIN :+: NRF2, NRF2 :-: Ferroptosis, FURIN :+: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P09958 33640301 _NA_ 2022/5/11 FerrDb team 1385 Ferroptosis circRHBG _NA_ circRHBG inhibits ferroptosis in PCOS cells through the circRHBG/miR-515-5p/SLC7A11 axis in PCOS. Human circRHBG :-: miR-515-5p, miR-515-5p :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ _NA_ 34532485 _NA_ 2022/5/11 FerrDb team 1386 Ferroptosis GALNT14 HGNC:22946 Altogether, GALNT14 is involved in the ferroptosis of ovarian cancer cells, and downregulation of GALNT14 can trigger ferroptosis in ovarian cancer cells. Human GALNT14 :+: EGFR, EGFR :+: mTOR, mTOR :-: Ferroptosis Validated 0 _NA_ Q96FL9 34643088 _NA_ 2022/5/16 FerrDb team 1387 Ferroptosis KLHDC3 HGNC:20704 KLHDC3 suppresses ferroptosis in a p14ARF and SLC7A11-dependent manner. Human KLHDC3 :-: p14ARF, p14ARF :-: NRF2, NRF2 :+: SLC7A11, SLC7A11 :-: Ferroptosis, KLHDC3 :-: p14ARF, p14ARF :-: MDM2, MDM2 :-: p53, p53 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ Q9BQ90 34743205 _NA_ 2022/5/16 FerrDb team 1388 Ferroptosis LINC01833 HGNC:52644 LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer. Human LINC01833 :-: miR-129-5p, miR-129-5p :-: PROM2, PROM2 :-: Ferroptosis Validated 0 _NA_ _NA_ 34728613 LncRNA RP11-89 in article. 2022/5/16 FerrDb team 1389 Ferroptosis circGFRA1 _NA_ Downregulation of circGFRA1 promotes ferroptosis in HER‐2‐positive BC. Human, mice circGFRA1 :-: miR‐1228, miR‐1228 :-: AIFM2, AIFM2 :-: Ferroptosis Validated 0 _NA_ _NA_ 34668628 _NA_ 2022/5/16 FerrDb team 1390 Ferroptosis MAPKAP1 HGNC:18752 mTORC2 ablation induces ferroptosis in memory CD4+ T cells. Mice MAPKAP1 :-: GSK3B, GSK3B :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ Q9BPZ7 34949833 Gene member of mTOR Complex 2 ( mTORC2 ). 2022/5/23 FerrDb team 1391 Ferroptosis MLST8 HGNC:24825 mTORC2 ablation induces ferroptosis in memory CD4+ T cells. Mice MLST8 :-: GSK3B, GSK3B :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ Q9BVC4 34949833 Gene member of mTOR Complex 2 ( mTORC2 ). 2022/5/23 FerrDb team 1392 Ferroptosis MTOR HGNC:3942 mTORC2 ablation induces ferroptosis in memory CD4+ T cells. Mice MTOR :-: GSK3B, GSK3B :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P42345 34949833 Gene member of mTOR Complex 2 ( mTORC2 ). 2022/5/23 FerrDb team 1393 Ferroptosis PRR5 HGNC:31682 mTORC2 ablation induces ferroptosis in memory CD4+ T cells. Mice PRR5 :-: GSK3B, GSK3B :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ P85299 34949833 Gene member of mTOR Complex 2 ( mTORC2 ). 2022/5/23 FerrDb team 1394 Ferroptosis RICTOR HGNC:28611 mTORC2 ablation induces ferroptosis in memory CD4+ T cells. Mice RICTOR :-: GSK3B, GSK3B :-: GPX4, GPX4 :-: Ferroptosis Deduced 0 _NA_ Q6R327 34949833 Gene member of mTOR Complex 2 ( mTORC2 ). 2022/5/23 FerrDb team 1395 Ferroptosis GSTM1 HGNC:4632 Moreover, the results suggest that GSTM1 may be a novel negative regulator of ferroptosis in addition to GPX4. Human GSTM1 :-: Ferroptosis Validated 0 _NA_ P09488 34586745 _NA_ 2022/5/24 FerrDb team 1396 Ferroptosis TERT HGNC:11730 In contrast, TERT-overexpressing cells exhibited marked elevation in SLC7A11 levels and thereby inhibited ferroptosis. Mice TERT :+: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ O14746 34716298 _NA_ 2022/5/24 FerrDb team 1397 Ferroptosis circ0097009 _NA_ Knockdown of circ0097009 promotes ferroptosis in HCC. Human circ0097009 :-: miR-1261, miR-1261 :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ _NA_ 33987373 _NA_ 2022/5/24 FerrDb team 1398 Ferroptosis TMEM161B-DT HGNC:43839 Knockdown of TMEM161B-AS1 down-regulated the expression of FANCD2 and CD44 by sponging hsa-miR-27a-3p, inhibited the proliferation, migration, invasion and promoted apoptosis, ferroptosis of U87 cells and U251 cells. Human TMEM161B-DT :-: hsa-miR-27a-3p, hsa-miR-27a-3p :-: FANCD2, FANCD2 :-: Ferroptosis, TMEM161B-DT :-: hsa-miR-27a-3p, hsa-miR-27a-3p :-: CD44, CD44 :-: Ferroptosis Validated 0 _NA_ _NA_ 34689169 lncRNA TMEM161B-AS1 in article. 2022/5/24 FerrDb team 1399 Ferroptosis circEPSTI1 _NA_ Silencing of circEPSTI1 induces ferroptosis mediated by SLC7A11. Human circEPSTI1 :-: miR-375, miR-375 :-: SLC7A11, SLC7A11 :-: Ferroptosis, circEPSTI1 :-: miR-409-3P, miR-409-3P :-: SLC7A11, SLC7A11 :-: Ferroptosis, circEPSTI1 :-: miR-515-5P, miR-515-5P :-: SLC7A11, SLC7A11 :-: Ferroptosis Validated 0 _NA_ _NA_ 33534779 _NA_ 2022/5/24 FerrDb team 1400 Ferroptosis MIR18A HGNC:31548 miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities. miR-18a directly targets ALOXE3 and suppresses its expression in GBM cells. Human MIR18A :-: ALOXE3, ALOXE3 :+: Ferroptosis Deduced 0 _NA_ _NA_ 33579899 _NA_ 2022/5/24 FerrDb team 1401 Ferroptosis RARRES2 HGNC:9868 Chemerin inhibition increases oxidized lipid and enhances ferroptosis susceptibility. Human RARRES2 :-: Ferroptosis Validated 0 _NA_ Q99969 33757970 Chemerin in article, which is encoded by the retinoic acid receptor responder 2 (RARRES2) gene. 2022/5/24 FerrDb team 1402 Ferroptosis USP11 HGNC:12609 USP11 ablation inhibits cell proliferation and sensitizes H1299 cells to ferroptosis during ROS-mediated stress. Human USP11 :+: NRF2, NRF2 :-: Ferroptosis Validated 0 _NA_ P51784 33531626 _NA_ 2022/5/24 FerrDb team