id rcd symbol hgncid evidence testin pathway confidence experiments caution uniprotac pmid remark latestupdate datasource 1 Ferroptosis DUSP1 HGNC:3064 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human DUSP1 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. P28562 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 2 Ferroptosis NOS2 HGNC:7873 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human NOS2 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. P35228 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 3 Ferroptosis NCF2 HGNC:7661 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human NCF2 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. P19878 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 4 Ferroptosis MT3 HGNC:7408 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human MT3 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. P25713 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 5 Ferroptosis UBC HGNC:12468 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human UBC :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. P0CG48 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 6 Ferroptosis ALB HGNC:399 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human ALB :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. P02768 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 7 Ferroptosis TXNRD1 HGNC:12437 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human TXNRD1 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. Q16881 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 8 Ferroptosis SRXN1 HGNC:16132 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human SRXN1 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. Q9BYN0 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 9 Ferroptosis GPX2 HGNC:4554 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human GPX2 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. P18283 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 10 Ferroptosis BNIP3 HGNC:1084 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human BNIP3 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. Q12983 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 11 Ferroptosis OXSR1 HGNC:8508 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human OXSR1 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. O95747 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 12 Ferroptosis SELENOS HGNC:30396 Expression was upregulated during ferroptosis induced by erastin or RSL3. Human SELENOS :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. Q9BQE4 24439385 SELS in article. May promote ferroptosis. 2022/3/9 FerrDb team 13 Ferroptosis ANGPTL7 HGNC:24078 Expression was downregulated during ferroptosis induced by erastin or RSL3. Human ANGPTL7 :?: Ferroptosis Deduced 0 Differentially expressed (|delta ct| > 2) under ferroptosis. O43827 24439385 May promote ferroptosis. 2022/3/9 FerrDb team 14 Ferroptosis SLC7A11 HGNC:11059 Similar to erastin treatment, silencing of this gene inhibits glutamate release. Erastin specifically inhibits SLC7A11-dependent system Xc- function. Human SLC7A11 :?: Ferroptosis Deduced 0 Further study needed to confirm connection to ferroptosis. Q9UPY5 24844246 May inhibit ferroptosis. 2022/3/9 FerrDb team 15 Ferroptosis DDIT4 HGNC:24944 Up-regulated (>= 2 fold) in erastin-treated samples. Human DDIT4 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q9NX09 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 16 Ferroptosis LOC284561 _NA_ Up-regulated (>= 2 fold) in erastin-treated samples. Human LOC284561 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. _NA_ 24844246 Not found in HGNC. May promote ferroptosis. 2022/3/9 FerrDb team 17 Ferroptosis ASNS HGNC:753 Up-regulated (>= 2 fold) in erastin-treated samples. Human ASNS :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P08243 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 18 Ferroptosis TSC22D3 HGNC:3051 Up-regulated (>= 2 fold) in erastin-treated samples. Human TSC22D3 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q99576 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 19 Ferroptosis DDIT3 HGNC:2726 Up-regulated (>= 2 fold) in erastin-treated samples. Human DDIT3 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P0DPQ6 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 20 Ferroptosis JDP2 HGNC:17546 Up-regulated (>= 2 fold) in erastin-treated samples. Human JDP2 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q8WYK2 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 21 Ferroptosis SESN2 HGNC:20746 Up-regulated (>= 2 fold) in erastin-treated samples. Human SESN2 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P58004 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 22 Ferroptosis SLC1A4 HGNC:10942 Up-regulated (>= 2 fold) in erastin-treated samples. Human SLC1A4 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P43007 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 23 Ferroptosis PCK2 HGNC:8725 Up-regulated (>= 2 fold) in erastin-treated samples. Human PCK2 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q16822 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 24 Ferroptosis TXNIP HGNC:16952 Up-regulated (>= 2 fold) in erastin-treated samples. Human TXNIP :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q9H3M7 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 25 Ferroptosis VLDLR HGNC:12698 Up-regulated (>= 2 fold) in erastin-treated samples. Human VLDLR :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P98155 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 26 Ferroptosis GPT2 HGNC:18062 Up-regulated (>= 2 fold) in erastin-treated samples. Human GPT2 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q8TD30 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 27 Ferroptosis PSAT1 HGNC:19129 Up-regulated (>= 2 fold) in erastin-treated samples. Human PSAT1 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q9Y617 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 28 Ferroptosis LURAP1L HGNC:31452 Up-regulated (>= 2 fold) in erastin-treated samples. Human LURAP1L :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q8IV03 24844246 C9ORF150 in article. May promote ferroptosis. 2022/3/9 FerrDb team 29 Ferroptosis SLC7A5 HGNC:11063 Up-regulated (>= 2 fold) in erastin-treated samples. Human SLC7A5 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q01650 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 30 Ferroptosis HERPUD1 HGNC:13744 Up-regulated (>= 2 fold) in erastin-treated samples. Human HERPUD1 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q15011 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 31 Ferroptosis XBP1 HGNC:12801 Up-regulated (>= 2 fold) in erastin-treated samples. Human XBP1 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P17861 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 32 Ferroptosis ATF3 HGNC:785 Up-regulated (>= 2 fold) in erastin-treated samples. Human ATF3 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P18847 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 33 Ferroptosis SLC3A2 HGNC:11026 Up-regulated (>= 2 fold) in erastin-treated samples. Human SLC3A2 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P08195 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 34 Ferroptosis CBS HGNC:1550 Up-regulated (>= 2 fold) in erastin-treated samples. Human CBS :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P35520 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 35 Ferroptosis ATF4 HGNC:786 Up-regulated (>= 2 fold) in erastin-treated samples. Human ATF4 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P18848 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 36 Ferroptosis ZNF419 HGNC:20648 Up-regulated (>= 2 fold) in erastin-treated samples. Human ZNF419 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q96HQ0 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 37 Ferroptosis KLHL24 HGNC:25947 Up-regulated (>= 2 fold) in erastin-treated samples. Human KLHL24 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q6TFL4 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 38 Ferroptosis TRIB3 HGNC:16228 Up-regulated (>= 2 fold) in erastin-treated samples. Human TRIB3 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q96RU7 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 39 Ferroptosis ZFP69B HGNC:28053 Up-regulated (>= 2 fold) in erastin-treated samples. Human ZFP69B :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q9UJL9 24844246 ZNF643 in article. May promote ferroptosis. 2022/3/9 FerrDb team 40 Ferroptosis ATP6V1G2 HGNC:862 Up-regulated (>= 2 fold) in erastin-treated samples. Human ATP6V1G2 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. O95670 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 41 Ferroptosis VEGFA HGNC:12680 Up-regulated (>= 2 fold) in erastin-treated samples. Human VEGFA :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P15692 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 42 Ferroptosis GDF15 HGNC:30142 Up-regulated (>= 2 fold) in erastin-treated samples. Human GDF15 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q99988 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 43 Ferroptosis TUBE1 HGNC:20775 Up-regulated (>= 2 fold) in erastin-treated samples. Human TUBE1 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q9UJT0 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 44 Ferroptosis ARRDC3 HGNC:29263 Up-regulated (>= 2 fold) in erastin-treated samples. Human ARRDC3 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. Q96B67 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 45 Ferroptosis CEBPG HGNC:1837 Up-regulated (>= 2 fold) in erastin-treated samples. Human CEBPG :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P53567 24844246 May promote ferroptosis. 2022/3/9 FerrDb team 46 Ferroptosis SNORA16A HGNC:32605 Down-regulated (>= 2 fold) in erastin-treated samples. Human SNORA16A :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. _NA_ 24844246 May inhibit ferroptosis. 2022/3/9 FerrDb team 47 Ferroptosis RGS4 HGNC:10000 Down-regulated (>= 2 fold) in erastin-treated samples. Human RGS4 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. P49798 24844246 May inhibit ferroptosis. 2022/3/9 FerrDb team 48 Ferroptosis BLOC1S5-TXNDC5 HGNC:42001 Down-regulated (>= 2 fold) in erastin-treated samples. Human BLOC1S5-TXNDC5 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. _NA_ 24844246 MUTED-TXNDC5 in article. May inhibit ferroptosis. 2022/3/9 FerrDb team 49 Ferroptosis LOC390705 _NA_ Down-regulated (>= 2 fold) in erastin-treated samples. Human LOC390705 :?: Ferroptosis Screened 0 Further study needed to confirm connection to ferroptosis. _NA_ 24844246 Not found in HGNC. May inhibit ferroptosis. 2022/3/9 FerrDb team 50 Ferroptosis EIF2S1 HGNC:3265 Phosphorylated in erastin-treated sample. Human EIF2S1 :?: Ferroptosis Deduced 0 _NA_ P05198 24844246 eIF2alpha in article. May promote ferroptosis. 2022/3/9 FerrDb team 51 Ferroptosis KIM-1 _NA_ Down-regulated upon Fer-1 appearance Mice KIM-1 :?: Ferroptosis Deduced 0 _NA_ _NA_ 25385600 Not found in HGNC. May promote ferroptosis. 2022/3/9 FerrDb team 52 Ferroptosis IL6 HGNC:6018 Down-regulated upon Fer-1 appearance Mice IL6 :?: Ferroptosis Deduced 0 _NA_ P05231 25385600 IL-6 in article. May promote ferroptosis. 2022/3/9 FerrDb team 53 Ferroptosis CXCL2 HGNC:4603 Down-regulated upon Fer-1 appearance Mice CXCL2 :?: Ferroptosis Deduced 0 _NA_ P19875 25385600 May promote ferroptosis. 2022/3/9 FerrDb team 54 Ferroptosis RELA HGNC:9955 Down-regulated upon Fer-1 appearance Mice RELA :?: Ferroptosis Deduced 0 _NA_ Q04206 25385600 p65 in article. May promote ferroptosis. 2022/3/9 FerrDb team 55 Ferroptosis HSD17B11 HGNC:22960 Enriched in RSL3-resistant cells. Human HSD17B11 :?: Ferroptosis Screened 0 _NA_ Q8NBQ5 25965523 May promote ferroptosis. 2022/3/9 FerrDb team 56 Ferroptosis AGPAT3 HGNC:326 Enriched in RSL3-resistant cells. Human AGPAT3 :?: Ferroptosis Screened 0 _NA_ Q9NRZ7 25965523 May promote ferroptosis. 2022/3/9 FerrDb team 57 Ferroptosis SETD1B HGNC:29187 Enriched in GPX4 inhibitor ML162-resistant cells. Human SETD1B :?: Ferroptosis Screened 0 _NA_ Q9UPS6 25965523 May promote ferroptosis. 2022/3/9 FerrDb team 58 Ferroptosis HMOX1 HGNC:5013 Its expression increased in response to artesunate-induced ferroptosis, indicating activation of ROS-mediated signaling pathways. Human HMOX1 :?: Ferroptosis Deduced 0 _NA_ P09601 26097885 HO-1 in article. May promote ferroptosis. 2022/3/9 FerrDb team 59 Ferroptosis TF HGNC:11740 Its expression is decreased in patients. Human TF :?: Ferroptosis Deduced 0 _NA_ P02787 26097885 May promote ferroptosis. 2022/3/9 FerrDb team 60 Ferroptosis FTL HGNC:3999 Its expression is decreased in patients. Human FTL :?: Ferroptosis Deduced 0 _NA_ P02792 26097885 May promote ferroptosis. 2022/3/9 FerrDb team 61 Ferroptosis RPL8 HGNC:10368 Significantly reduced in tumor tissues Human RPL8 :?: Ferroptosis Deduced 0 _NA_ P62917 26097885 May promote ferroptosis. 2022/3/9 FerrDb team 62 Ferroptosis ATP5MC3 HGNC:843 Significantly reduced in tumor tissues Human ATP5MC3 :?: Ferroptosis Deduced 0 _NA_ P48201 26097885 ATP5G3 in article. May promote ferroptosis. 2022/3/9 FerrDb team 63 Ferroptosis TFRC HGNC:11763 Expression of this gene is increased in patients. Human TFRC :?: Ferroptosis Deduced 0 _NA_ P02786 26097885 May inhibit ferroptosis. 2022/3/9 FerrDb team 64 Ferroptosis MAFG HGNC:6781 The interaction between NRF2 and MafG was increased in response to erastin and sorafenib. Human, mice MAFG :?: Ferroptosis Deduced 0 _NA_ O15525 26403645 May inhibit ferroptosis. 2022/3/9 FerrDb team 65 Ferroptosis IL33 HGNC:16028 IL-33 upregulation is a feature of ferroptosis. Ferrostatin-1, an inhibitor of ferroptosis, prevented the upregulation of IL-33. Mice IL33 :?: Ferroptosis Deduced 0 _NA_ O95760 27352622 IL-33 in article. May promote ferroptosis. 2022/3/9 FerrDb team 66 Ferroptosis FTH1 HGNC:3976 An increase of endogenous FTH1 level during ferroptosis. Degradation of FTH1 protein upon ferroptosis induction. Human FTH1 :?: Ferroptosis Validated 0 "An error may exist in the original article, where the authors wrote ""ferritin light chain 1 (FTH1)"". According to HGNC, FTH1 is the official symbol for ""ferritin heavy chain 1""." P02794 27514700 _NA_ 2022/3/9 FerrDb team 67 Ferroptosis HAMP HGNC:15598 Erastin-induced mRNA expression is downregulated in FANCD2-deficient cells. Mice HAMP :?: Ferroptosis Deduced 0 _NA_ P81172 27773819 May inhibit ferroptosis. 2022/3/9 FerrDb team 68 Ferroptosis STEAP3 HGNC:24592 Erastin-induced mRNA expression is downregulated in FANCD2-deficient cells. Mice STEAP3 :?: Ferroptosis Deduced 0 _NA_ Q658P3 27773819 May inhibit ferroptosis. 2022/3/9 FerrDb team 69 Ferroptosis DRD5 HGNC:3026 Ferroptotic erastin induces DRD5 gene expression in ferroptosis. Human DRD5 :?: Ferroptosis Deduced 0 _NA_ P21918 27793671 May promote ferroptosis. 2022/3/9 FerrDb team 70 Ferroptosis GPX4 HGNC:4556 Erastin promoted GPX4 degradation. Antiferroptotic dopamine increased the protein stability of glutathione peroxidase 4. Human GPX4 :?: Ferroptosis Deduced 0 Has been proved to be a suppressor (PMID 25824823). P36969 27793671 May inhibit ferroptosis. 2022/3/9 FerrDb team 71 Ferroptosis DRD4 HGNC:3025 Antiferroptotic dopamine suppressed dopamine receptor D4 protein degradation. Ferroptotic erastin promotes DRD4 protein degradation. Human DRD4 :?: Ferroptosis Deduced 0 _NA_ P21917 27793671 May inhibit ferroptosis. 2022/3/9 FerrDb team 72 Ferroptosis MAP3K5 HGNC:6857 Cold stress evokes ferroptosis, and the ASK1‐p38 pathway is activated downstream of lipid peroxide, leading to the cell death. ASK1‐p38 axis is also activated in the erastin‐induced ferroptosis model. Human MAP3K5 :?: Ferroptosis Deduced 0 _NA_ Q99683 28887319 ASK1 in article. May promote ferroptosis. 2022/3/9 FerrDb team 73 Ferroptosis MAPK14 HGNC:6876 Cold stress evokes ferroptosis, and the ASK1‐p38 pathway is activated downstream of lipid peroxide, leading to the cell death. ASK1‐p38 axis is also activated in the erastin‐induced ferroptosis model. Human MAPK14 :?: Ferroptosis Deduced 0 _NA_ Q16539 28887319 p38 in article. May promote ferroptosis. 2022/3/9 FerrDb team 74 Ferroptosis SLC2A1 HGNC:11005 Increased at LSH overexpression. Decreased at LSH knockdown. LSH can inhibit ferroptosis. Human SLC2A1 :?: Ferroptosis Deduced 0 _NA_ P11166 28900510 GLUT1 in article. May inhibit ferroptosis. 2022/3/9 FerrDb team 75 Ferroptosis SLC2A3 HGNC:11007 Decreased at LSH knockdown. LSH can inhibit ferroptosis. Human SLC2A3 :?: Ferroptosis Deduced 0 _NA_ P11169 28900510 GLUT3 in article. May inhibit ferroptosis. 2022/3/9 FerrDb team 76 Ferroptosis SLC2A6 HGNC:11011 Increased at LSH overexpression. Decreased at LSH knockdown. LSH can inhibit ferroptosis. Human SLC2A6 :?: Ferroptosis Deduced 0 _NA_ Q9UGQ3 28900510 GLUT6 in article. May inhibit ferroptosis. 2022/3/9 FerrDb team 77 Ferroptosis SLC2A8 HGNC:13812 Decreased at LSH knockdown. LSH can inhibit ferroptosis. Human SLC2A8 :?: Ferroptosis Deduced 0 _NA_ Q9NY64 28900510 GLUT8 in article. May inhibit ferroptosis. 2022/3/9 FerrDb team 78 Ferroptosis SLC2A12 HGNC:18067 Increased at LSH overexpression. Decreased at LSH knockdown. LSH can inhibit ferroptosis. Human SLC2A12 :?: Ferroptosis Deduced 0 _NA_ Q8TD20 28900510 GLUT12 in article. May inhibit ferroptosis. 2022/3/9 FerrDb team 79 Ferroptosis GLUT13 _NA_ Increased at LSH overexpression. Decreased at LSH knockdown. LSH can inhibit ferroptosis. Human GLUT13 :?: Ferroptosis Deduced 0 _NA_ _NA_ 28900510 Not found in HGNC. May inhibit ferroptosis. 2022/3/9 FerrDb team 80 Ferroptosis SLC2A14 HGNC:18301 Decreased at LSH knockdown. LSH can inhibit ferroptosis. Human SLC2A14 :?: Ferroptosis Deduced 0 _NA_ Q8TDB8 28900510 GLUT14 in article. May inhibit ferroptosis. 2022/3/9 FerrDb team 81 Ferroptosis EIF2AK4 HGNC:19687 CHAC1 degradation of GSH enhances cystine-starvation-induced ferroptosis through the activated GCN2-eIF2 alpha-ATF4 pathway. Human EIF2AK4 :?: Ferroptosis Deduced 0 _NA_ Q9P2K8 29383104 GCN2 in article. May promote ferroptosis. 2022/3/9 FerrDb team 82 Ferroptosis EIF2S1 HGNC:3265 CHAC1 degradation of GSH enhances cystine-starvation-induced ferroptosis through the activated GCN2-eIF2 alpha-ATF4 pathway. Human EIF2S1 :?: Ferroptosis Deduced 0 _NA_ P05198 29383104 eIF2alpha in article. May promote ferroptosis. 2022/3/9 FerrDb team 83 Ferroptosis ATF4 HGNC:786 CHAC1 degradation of GSH enhances cystine-starvation-induced ferroptosis through the activated GCN2-eIF2 alpha-ATF4 pathway. Human ATF4 :?: Ferroptosis Deduced 0 _NA_ P18848 29383104 May promote ferroptosis. 2022/3/9 FerrDb team 84 Ferroptosis ALOX5 HGNC:435 Overexpression sensitizes cells to ferroptosis. Human ALOX5 :?: Ferroptosis Deduced 0 Not essential but may play a role in ferroptotis initiation. P09917 29632885 5-LOX in article 2022/3/9 FerrDb team 85 Ferroptosis ALOX12 HGNC:429 Overexpression sensitizes cells to ferroptosis. Human ALOX12 :?: Ferroptosis Deduced 0 Not essential but may play a role in ferroptotis initiation. P18054 29632885 p12-LOX in article 2022/3/9 FerrDb team 86 Ferroptosis ALOX15 HGNC:433 Overexpression sensitizes cells to ferroptosis. Human ALOX15 :?: Ferroptosis Deduced 0 Not essential but may play a role in ferroptotis initiation. P16050 29632885 15-LOX-1 in article 2022/3/9 FerrDb team 87 Ferroptosis ALOX5 HGNC:435 Necessary for hemin‐induced ferroptosis in vitro. Mice ALOX5 :?: Ferroptosis Deduced 0 _NA_ P09917 30294906 May promote ferroptosis. 2022/3/9 FerrDb team 88 Ferroptosis ACSF2 HGNC:26101 Increased in ferroptotic events. Decreased in DFO-induced resistance to ferroptosis. Rat ACSF2 :?: Ferroptosis Deduced 0 _NA_ Q96CM8 30539824 There is a corrigendum for this article. May promote ferroptosis. 2022/3/9 FerrDb team 89 Ferroptosis IREB2 HGNC:6115 Increased in ferroptotic events. Decreased in DFO-induced resistance to ferroptosis. Rat IREB2 :?: Ferroptosis Deduced 0 _NA_ P48200 30539824 There is a corrigendum for this article. May promote ferroptosis. 2022/3/9 FerrDb team 90 Ferroptosis HMGB1 HGNC:4983 Associated with ferroptotic cell death. Ferroptosis activators induce HMGB1 release. Human, mice HMGB1 :?: Ferroptosis Deduced 0 _NA_ P09429 30686534 May promote ferroptosis. 2022/3/9 FerrDb team 91 Ferroptosis HMOX1 HGNC:5013 Required for DOX-induced ferroptosis. Mice HMOX1 :?: Ferroptosis Deduced 0 _NA_ P09601 30692261 May promote ferroptosis. 2022/3/9 FerrDb team 92 Ferroptosis NFE2L2 HGNC:7782 DOX treatment induced ferroptosis. Protein and mRNA levels of Nrf2 were increased after DOX treatment. Mice NFE2L2 :?: Ferroptosis Deduced 0 _NA_ Q16236 30692261 NRF2 in article. 2022/3/9 FerrDb team 93 Ferroptosis ELAVL1 HGNC:3312 Binds to and increases the expression of the negative ferroptosis regulator LINC00336. Human ELAVL1 :?: Ferroptosis Deduced 0 _NA_ Q15717 30787392 May inhibit ferroptosis. 2022/3/9 FerrDb team 94 Ferroptosis SLC3A2 HGNC:11026 Strongly correlated with resistance to ferroptosis inducers. Human SLC3A2 :?: Ferroptosis Deduced 0 _NA_ P08195 31043744 May inhibit ferroptosis. 2022/3/9 FerrDb team 95 Ferroptosis SLC7A11 HGNC:11059 Strongly correlated with resistance to ferroptosis inducers. Human SLC7A11 :?: Ferroptosis Deduced 0 _NA_ Q9UPY5 31043744 May inhibit ferroptosis. 2022/3/9 FerrDb team 96 Ferroptosis TFAP2C HGNC:11744 Activated by ferroptosis inhibitor selenium. Mice TFAP2C :?: Ferroptosis Deduced 0 _NA_ Q92754 31056284 May inhibit ferroptosis. 2022/3/9 FerrDb team 97 Ferroptosis SP1 HGNC:11205 Activated by ferroptosis inhibitor selenium. Mice SP1 :?: Ferroptosis Deduced 0 _NA_ P08047 31056284 May inhibit ferroptosis. 2022/3/9 FerrDb team 98 Ferroptosis HBA1 HGNC:4823 Upregulated in cells treated with ferroptosis inducer erastin. Stimulates ferroptosis possibly in a GSH-dependent manner. Human HBA1 :?: Ferroptosis Deduced 0 _NA_ P69905 31108460 May promote ferroptosis. 2022/3/9 FerrDb team 99 Ferroptosis NNMT HGNC:7861 Upregulated in cells treated with ferroptosis inducer erastin. Stimulates ferroptosis possibly in a GSH-dependent manner. Human NNMT :?: Ferroptosis Deduced 0 _NA_ P40261 31108460 May promote ferroptosis. 2022/3/9 FerrDb team 100 Ferroptosis PLIN4 HGNC:29393 Upregulated in cells treated with ferroptosis inducer erastin. Stimulates ferroptosis possibly in a GSH-dependent manner. Human PLIN4 :?: Ferroptosis Deduced 0 _NA_ Q96Q06 31108460 May promote ferroptosis. 2022/3/9 FerrDb team 101 Ferroptosis HIC1 HGNC:4909 Essential for stimulation of pro-ferroptotic gene transcription upon ferroptosis induction. Human HIC1 :?: Ferroptosis Deduced 0 _NA_ Q14526 31108460 May promote ferroptosis. 2022/3/9 FerrDb team 102 Ferroptosis STMN1 HGNC:6510 Downregulated in cells treated with ferroptosis inducer erastin. Suppresses ferroptosis possibly in a GSH-dependent manner. Human STMN1 :?: Ferroptosis Deduced 0 _NA_ P16949 31108460 May inhibit ferroptosis. 2022/3/9 FerrDb team 103 Ferroptosis RRM2 HGNC:10452 Downregulated in cells treated with ferroptosis inducer erastin. Suppresses ferroptosis possibly in a GSH-dependent manner. Human RRM2 :?: Ferroptosis Deduced 0 _NA_ P31350 31108460 May inhibit ferroptosis. 2022/3/9 FerrDb team 104 Ferroptosis CAPG HGNC:1474 Downregulated in cells treated with ferroptosis inducer erastin. Suppresses ferroptosis possibly in a GSH-dependent manner. Human CAPG :?: Ferroptosis Deduced 0 _NA_ P40121 31108460 May inhibit ferroptosis. 2022/3/9 FerrDb team 105 Ferroptosis HNF4A HGNC:5024 Essential for stimulation of anti-ferroptotic gene transcription. Human HNF4A :?: Ferroptosis Deduced 0 _NA_ P41235 31108460 May inhibit ferroptosis. 2022/3/9 FerrDb team 106 Ferroptosis NGB HGNC:14077 Human neuroglobin (hNgb)-EGFP-expressing SH-SY5Y cells to be significantly more resistant to ferroptosis induction. Human NGB :?: Ferroptosis Deduced 0 _NA_ Q9NPG2 31405213 May inhibit ferroptosis. 2022/3/9 FerrDb team 107 Ferroptosis YWHAE HGNC:12851 Required by RSL3 (a ferroptosis inducer) to inactivate GPX4 (a ferroptosis inhibitor). Human YWHAE :?: Ferroptosis Deduced 0 _NA_ P62258 31581313 14-3-3epsilon in article. May promote ferroptosis. 2022/3/9 FerrDb team 108 Ferroptosis GABPB1 HGNC:4074 Downregulated by lncRNA GABPB1-AS1 upon erastin treatment. Human GABPB1 :?: Ferroptosis Deduced 0 _NA_ Q06547 31700067 May inhibit ferroptosis. 2022/3/9 FerrDb team 109 Ferroptosis AURKA HGNC:11393 Inhibition of AURKA or reconstitution of miR-4715-3p inhibited GPX4 and induced cell death, suggesting a link between AURKA and ferroptosis. Human AURKA :?: Ferroptosis Predicted 0 _NA_ O14965 31740746 May inhibit ferroptosis. 2022/3/9 FerrDb team 110 Ferroptosis MIR4715 HGNC:41666 Inhibition of AURKA or reconstitution of miR-4715-3p inhibited GPX4 and induced cell death, suggesting a link between AURKA and ferroptosis. Human MIR4715 :?: Ferroptosis Predicted 0 _NA_ _NA_ 31740746 miR-4715-3p in article. May promote ferroptosis. 2022/3/9 FerrDb team 111 Ferroptosis RIPK1 HGNC:10019 Reduced expression results in resistance to ferroptosis. Human RIPK1 :?: Ferroptosis Deduced 0 _NA_ Q13546 31827280 May promote ferroptosis. 2022/3/9 FerrDb team 112 Ferroptosis PRDX1 HGNC:9352 Necessary to ferroptosis-related lipid peroxidation. Human PRDX1 :?: Ferroptosis Deduced 0 _NA_ Q06830 31901729 May promote ferroptosis. 2022/3/9 FerrDb team 113 Ferroptosis MIR30B HGNC:31625 Upregulation of miR-30b-5p in preeclampsia models plays a pivotal role in ferroptosis. Human, rat MIR30B :?: Ferroptosis Deduced 0 _NA_ _NA_ 31926626 miR-30b-5p in article. May promote ferroptosis. 2022/3/9 FerrDb team 114 Ferroptosis MMP13 HGNC:7159 Moreover, erastin, the most classic inducer of ferroptosis, promoted matrix metalloproteinase 13 (MMP13) expression while inhibited type II collagen (collagen II) expression in chondrocytes. Human MMP13 :?: Ferroptosis Deduced 0 _NA_ P45452 33376672 May promote ferroptosis. 2022/3/9 FerrDb team 115 Ferroptosis LRRFIP1 HGNC:6702 Furthermore, LRRFIP1 levels were increased by pro-oxidant conditions such as ODG or the ferroptosis inducer erastin. Rat LRRFIP1 :?: Ferroptosis Deduced 0 _NA_ Q32MZ4 33265962 May promote ferroptosis. 2022/3/9 FerrDb team 116 Ferroptosis CBR1 HGNC:1548 As expected, ROS levels increased in CBR1 knockdown cells (Fig. 2G–H). Human CBR1 :?: Ferroptosis Deduced 0 _NA_ P16152 34673014 May inhibit ferroptosis. 2022/3/9 FerrDb team