售后

HIGH:The variant is assumed to have high (disruptive) impact in the protein, probably causing protein truncation, loss of function or triggering nonsense mediated decay

MODERATE:A non-disruptive variant that might change protein effectiveness

LOW:Assumed to be mostly harmless or unlikely to change protein behavior

MODIFIER:Usually non-coding variants or variants affecting non-coding genes, where predictions are difficult or there is no evidence of impact